An Exploratory Clinical Study Evaluating the Impact of Interferon Consolidation Therapy on Intrahepatic cccDNA Levels in Chronic Hepatitis B Patients Who Achieved Clinical Cure With Peginterferon α-2b Therapy.

This is a single-center, prospective, exploratory clinical study. The study plans to enroll 30 chronic hepatitis B (CHB) patients which achieved HBsAg clearance based peginterferon α-2b treatment. Eligible subjects will receive either 12-24 weeks interferon consolidation therapy (180μg administered subcutaneously in the abdomen or thigh once weekly) or not according to physician's recommendation and patient's preference, with regular follow-up for HBV recurrence. Patients will be followed up every 12 weeks. The study will evaluate changes in intrahepatic covalently closed circular DNA (cccDNA) and peripheral blood HBV pregenomic RNA (pgRNA) levels after achieving HBsAg clearance.

Start Date20 Apr 2025

Sponsor / Collaborator

Xiamen Hospital of Traditional Chinese Medicine

ITMCTR2024000554

/ RecruitingNot Applicable

The distribution of TCM constitution and syndrome type in patients with type 2 diabetes with blood glucose fluctuation and the correlation with influencing factors

Start Date20 Nov 2024

Sponsor / Collaborator

Xiamen Hospital of Traditional Chinese Medicine

ChiCTR2400086704

/ SuspendedNot Applicable

A multicenter, cross-sectional study of psychosomatic symptoms, traditional Chinese medicine evidence, psychological resilience, and current status of social support for oncology patients during adjuvant chemotherapy in breast cancer patients

Start Date15 Jul 2024

Sponsor / Collaborator

Xiamen Hospital of Traditional Chinese Medicine

100 Clinical Results associated with Xiamen Hospital of Traditional Chinese Medicine

0 Patents (Medical) associated with Xiamen Hospital of Traditional Chinese Medicine

270

Literatures (Medical) associated with Xiamen Hospital of Traditional Chinese Medicine

01 Nov 2025·Talanta

Detection of hyaluronidase in urine using hyaluronic acid-coated silver nanoparticles-based surface-enhanced Raman spectroscopy for the diagnosis of bladder cancer

Article

Author: Gao, Xingen ; Gong, Xianqiong ; Zhang, Hongyi ; Wang, Fuqiang ; Lin, Juqiang ; Qiu, Xinhao ; Wu, Haochen

Bladder cancer, a malignancy of the urinary tract, has shown a rising incidence rate in recent years. Current diagnostic methods often suffer from issues such as invasiveness, high costs, or insufficient sensitivity, creating an urgent need for a fast, simple, and non-invasive diagnostic approach. In this study, a novel diagnostic method for bladder cancer is proposed, using hyaluronic acid-coated silver nanoparticles (HA-AgNPs) as the substrate for surface-enhanced Raman scattering (SERS) to detect hyaluronidase (HAase), a biomarker for bladder cancer, in urine. This method is based on the hydrolysis of hyaluronic acid on HA-AgNPs by HAase, which generates oligomers and causes the breakdown of HA-AgNPs into smaller nanoparticles. The formation of oligomers enhances the surface shielding effect of the silver nanoparticles, promoting aggregation between particles and significantly weakening the SERS signal. By detecting changes in the SERS signal using Rhodamine (R6G), HAase was quantified. The experimental results show that there is a good linear relationship (R² = 0.9991) between the SERS signal and the HAase concentration in the range of 3 × 10^-4 U/mL to 3 × 10¹ U/mL. The method demonstrates high sensitivity and can effectively detect HAase concentration in urine. Combining principal component analysis (PCA) with linear discriminant analysis (LDA), effective classification of SERS spectra from 42 normal and 40 bladder cancer urine samples was achieved. Experimental results show that the sensitivity and specificity of this algorithm in distinguishing between the normal and bladder cancer groups reached 95.2 % and 95 %, respectively.

01 Jun 2025·SLAS Technology

Association of the characteristics of brain magnetic resonance imaging with genes related to disease onset in schizophrenia patients

Article

Author: Lu, Zirong ; Zhang, Jingbin ; Chen, Shaoguang ; Cao, Fengling ; Lin, Jiantu ; Wang, Bo

BACKGROUNDSchizophrenia (SCH) is a complex neurodevelopmental disorder, whose pathogenesis is not fully elucidated. This article aims to reveal disease-specific brain structural and functional changes and their potential genetic basis by analyzing the characteristics of brain magnetic resonance imaging (MRI) in SCH patients and related gene expression patterns.METHODSDifferentially expressed genes (DEGs) between SCH and healthy control (NC) groups in the GSE48072 dataset were identified and functionally analyzed, and a protein-protein interaction (PPI) network was fabricated to screen for core genes (CGs). Meanwhile, MRI data from the COBRE, the Human Connectome Project (HCP), the 1000 Functional Connectomes Project (FCP), and the Consortium for Reliability and Reproducibility (CoRR) were utilized to explore differences in brain activity patterns between SCH patients and NC group using a 3D deep aggregation network (3D DANet) machine learning approach. A correlation analysis was performed between the identified CGs and MRI imaging characteristics.RESULTS82 DEGs were collected from the GSE48072 dataset, primarily involved in cytotoxic granules, growth factor binding, and graft-versus-host disease pathways. The construction of the PPI network revealed KLRD1, KLRF1, CD244, GZMH, GZMA, GZMB, PRF1, and SLAMF6 as CGs. SCH patients exhibited relatively enhanced activity patterns in the frontoparietal attention network (FAN) and default mode network (DMN) across four datasets, while showing a trend of weakening in most other networks. The 3D DANet demonstrated higher accuracy, specificity, and sensitivity in brain image classification. The correlation between enhancement of the DMN and genetic abnormalities was the strongest, followed by the enhancement of the frontal and parietal attention networks. In contrast, the correlation between the weakening of the sensory-motor network and occipital network and genetic abnormalities was relatively weak. The strongest correlation was observed between MRI characteristics and the KLRD1 and CD244 genes.CONCLUSIONThe granzyme-mediated programmed cell death signaling pathway is related to pathogenesis of SCH, and CD244 may serve as potential biological markers for diagnosing SCH. The correlation between enhancement of the DMN and genetic abnormalities was the strongest, followed by the enhancement of the frontal and parietal attention networks. In contrast, the correlation between weakening of the sensory-motor network and occipital network and genetic abnormalities was relatively weak. Additionally, the strongest correlation was observed between MRI features and the KLRD1 and CD244 genes. The use of the 3D DANet method has improved the detection precision of brain structural and functional changes in SCH patients, providing a new perspective for understanding the biological basis of the disease.

01 Jun 2025·Phytomedicine

Linghe granules reduces hepatic lipid accumulation in Non-alcoholic fatty liver disease through regulating lipid metabolism and redox balance

Article

Author: Wang, Jia ; Fang, Dongdong ; Hu, Yuting ; Lu, Yiyu ; Zhang, Hua ; Li, Ni'ao ; Cai, Hong ; Zhang, Rumian ; Zhou, Qianmei

BACKGROUNDNon-alcoholic fatty liver disease (NAFLD) is a prevalent liver disorder with no approved pharmacological therapies. Linghe granules, a hospital-based formulation derived from a classic prescription, have demonstrated potential in reducing hepatic fat accumulation and improving metabolic health. This study provides a novel, comprehensive assessment of Linghe granules, integrating clinical, preclinical, and molecular analyses for NAFLD management.PURPOSEThis study aims to evaluate the therapeutic efficacy of Linghe granules in alleviating NAFLD through an integrated approach.METHODSA clinical trial involving 40 patients with NAFLD was conducted, with participants divided into a control group (lifestyle interventions) and a treatment group (lifestyle interventions plus oral Linghe granules). Various metabolic and liver function indicators were assessed before and after treatment. Additionally, a high-fat diet (HFD) was used to induce a NAFLD model in rat, followed by treatment with different doses of Linghe granules. In vitro studies on HepG2 and L02 cells were performed to the effects of the granules on lipid metabolism. Transcriptomic profiling, Weighted Gene Co-expression Network Analysis (WGCNA), Dynamic Network Biomarkers (DNB) analysis, and molecular docking were employed to explore the underlying mechanisms.RESULTSLinghe granules led to significant reductions in BMI, liver enzymes (AST, ALT), triglycerides, LDL-C, and GGT in patients with NAFLD, accompanied by a notable decrease in hepatic fat accumulation. In the rat model, treatment improved liver weight, liver function, and lipid metabolism. In vitro, Linghe granules decreased lipid accumulation and regulated key lipid metabolism markers, including sterol regulatory element-binding protein 1 (SREBP-1), stearoyl-CoA desaturase 1 (SCD1), and fatty acid-binding protein 5 (FABP5). Mechanistic analyses revealed that Linghe granules modulated oxidative stress-related pathways and genes involved in lipid metabolism.CONCLUSIONThis study represents the first integrated evaluation of Linghe granules' efficacy and mechanisms in treating NAFLD, demonstrating their potential to improve liver function, reduce lipid accumulation, and modulate key metabolic markers. These results suggest that Linghe granules may serve as an effective adjunctive treatment for NAFLD.

100 Deals associated with Xiamen Hospital of Traditional Chinese Medicine

100 Translational Medicine associated with Xiamen Hospital of Traditional Chinese Medicine

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