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Overview

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Neoplasms

Respiratory Diseases

Digestive System Disorders

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	2

Top 5 Drug Type	Count

Small molecule drug	2

Top 5 Target	Count

caspase 3(Caspase-3)	2

AbstractThis paper presents the development of a new hyperchaotic system, created by the extension of the established Lü system to the four-dimension. The complex dynamics of this new system are explored through both theoretical analysis and numerical simulations. The study focuses on the system’s dynamic behavior, equilibrium points, Lyapunov exponents, and Poincaré sections, as well as bifurcation diagrams and coexisting attractors to thoroughly characterize its properties. Moreover, two main methods were investigated to control the hyperchaos: linear feedback control and adaptive control. These approaches aim to stabilize the hyperchaotic system at unstable equilibrium points, even when system parameters are either known or unknown. Numerical simulations are performed to illustrate the effectiveness of the proposed controllers.

01 Apr 2025·Food Chemistry

Enzymatic browning in fresh extra virgin olive oil (EVOO): Detection of polyphenol oxidase, assessing moisture impact, and revealing the anti-browning capacity of EVOO

Article

Author: Barkat, Malika ; Pretzler, Matthias ; Derardja, Ala Eddine ; Rompel, Annette ; Dassamiour, Saliha

This study investigates the presence of active olive polyphenol oxidase (OePPO) in freshly extracted extra virgin olive oil (EVOO) and its role in triggering enzymatic browning during EVOO storage. OePPO's presence in EVOO was validated through its distinct molecular weights observed in SDS-PAGE gels. The generation of quinones in EVOO was tracked spectrophotometrically over a storage period of one month, revealing browning reactions, particularly in the early days of storage, followed by a decline concurrent with water sedimentation. Introducing various water percentages into EVOO revealed the critical and proportional impact of moisture content on enzymatic browning. Microscopic examination showed the formation of colloidal matter around water microdroplets suspected to accommodate browning reactions. The reduction of EVOO moisture content to < 0.15 % coincided with a progressive decrease in browning across all samples, hinting at a potential anti-browning capacity of EVOO. A novel analytical method is proposed to evaluate EVOO's anti-browning capacity, utilizing chemically oxidized 4-tert-butylcatechol (TBC) quinones. After one month of storage, a significant decrease in total phenols and antioxidant activity proportional to the moisture content and enzymatic browning was noted in EVOO samples. To prevent such losses, the EVOO extraction process should effectively minimize moisture content to less than 0.15 %.

14 Mar 2025·Modern Physics Letters A

Time-dependent Dunkl–Schrödinger equation with an angular-dependent potential

Author: Benchikha, A. ; Hamil, B. ; Lütfüoğlu, B. C. ; Khantoul, B.

In this paper, we investigate the analytical solution of the time-dependent Schrödinger equation for a harmonic oscillator with time-dependent mass and frequency, coupled with angular-dependent potential energy by utilizing the Dunkl derivatives. To obtain the solution, we employ the Lewis–Riesenfeld invariant methodology. Our approach broadens the scope of quantum mechanical analyses, offering exact solutions and new insights into dynamic quantum systems under varying conditions.

100 Deals associated with Constantine 1 University

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100 Translational Medicine associated with Constantine 1 University

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Pipeline

Pipeline Snapshot as of 01 Aug 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

2

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Compounds 18(Université Frères Mentouri-Constantine1) ( caspase 3 )	Stomach Cancer More	Preclinical
Compounds 17(Université Frères Mentouri-Constantine1) ( caspase 3 )	Stomach Cancer More	Preclinical