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Ftase(Protein farnesyltransferase)	1

The GdMCr₂O₅ (M = Na, K, Cs) chromites were synthesized from Gd₂O₃, Cr₂O₃, and M₂CO₃ by solid-state reactions and have a tetragonal structure.The heat capacity of the chromites is measured from 298.15 to 673 K using a heat-pulse calorimeter.The data for GdKCr₂O₅ and GdCsCr₂O₅ show anomalies at 373 and 398 K, resp., attributable to a 2nd-order phase transition.The best fit equations for the C⁰_p(T) data are derived.Elec. measurements in the range 303-383 K attest to semiconducting behavior of the chromites.

01 Jan 2000·Chemistry of Natural Compounds

Possible conformations and relative stability of the 7-membered ring in 1α,5β,6,7α(H)-and 1β,5α,6,7α(H)-guai-11(13)-en-6,12-olides

Author: Turdybekov, K. M. ; Fazylova, A. S.

Stereoisomers of guaienolides I are calculated using mol. mechanics.The possibility of forming various conformations in the 7-membered ring is examined as a function of the fusion to the 5-membered C-ring.The effect of the Me orientation on the conformation of the 7-membered ring and the relative stability of the conformers are discussed.

01 Jan 2000·Molekuliarnaia genetika, mikrobiologiia i virusologiia

[Genetic control of the biotransformation of plant terpenoids by Pseudomonas strain SP.1K1].

Article

Author: Adekenov, S M ; Ledentsov, A A ; Pavlosiuk, O S ; Lu, K G

Bacterial strain Pseudomonas sp. 1K1 can grow on sesquiterpene lactones isolated from medicinal plants of Kazakhstan due to 18-kb conjugative plasmid. This plasmid is stable in heterologous environment (E. coli and B. subtilis), which was proven by transformation transfer. The possibility of using salicylate as p1K1 selective agent has been demonstrated.

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Pipeline

Pipeline Snapshot as of 01 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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