Objective: To investigate the effects of preoperative prophylactic use of pranoprofen eye drops on anterior chamber inflammation in patients with age-related cataracts.Methods: Age-related cataract patients who underwent phacoemulsification combined with intraocular lens implantation at the author′s hospital from June to Oct. 2022 were selected and randomly divided into treatment group (n=24) and control group (n=25).The control group received levofloxacin eye drops for 3 days before surgery, while the treatment group received pranoprofen eye drops in addition to levofloxacin eye drops, the postoperative anterior chamber planktonic cells, best corrected visual acuity (BCVA), corneal edema and interleukin 6 (IL-6) levels in the aqueous humor were compared between the two groups, and correlation analyses were performed.Results: The content of anterior chamber planktonic cells in the treatment group was lower than that in the control group on the 3rd day after surgery (P<0.05), there was no significant difference in anterior chamber planktonic cells, BCVA and degree of corneal edema between the two groups on the 7th day after surgery (P>0.05).There was no significant difference in IL-6 content in the aqueous humor between the treatment group and the control group (P>0.05).Correlation anal. showed a pos. correlation between nuclear grade and preoperative visual acuity (r=0.789, P<0.01), as well as the degree of corneal edema on the 7th day after surgery (r=0.490, P<0.01), however, there was no correlation between IL-6 levels in the aqueous humor and anterior chamber cells on the 3rd day after surgery (r=-0.063, P>0.05), anterior chamber planktonic cells on the 7th day after surgery (r=0.217, P>0.05) and corneal edema after one week (r=0.000, P>0.05).Conclusion: Prophylactic use of pranoprofen eye drops before surgery in patients with age-related cataracts does not affect the content of IL-6 in the aqueous humor but can alleviate early postoperative ocular inflammation.