Objective To systematically evaluate the efficacy and safety of Yiqi Fumai Lyophilized Injection(YQFM) combined with western medicine in the treatment of angina pectoris of coronary heart disease. Methods CNKI, Wanfang Data, VIP, CBM, PubMed, EMbase, the Cochrane library, and Web of science were searched from the date of establishment of the databases to August31, 2021. The studies of randomized controlled trial(RCT) and controlled clin. trial(CCT) of YQFM combined with chem. drug and chem. drug alone in the treatment of angina pectoris were comprehensively collected. evaluated studies by the Cochrane risk assessment form. Meta-anal. of the included studies was performed using RevMan 5.3 software. Results A total of nine RCTs and one CCT were included, with a total sample size of 1 207 cases, including 607 cases in the exptl. group and 600 cases in the control group. Meta-anal. showed that compared with WM alone, YQFM combined with chem. drug could reduce the incidence of cardiovascular events [RR = 0.14, 95%CI(0.06, 0.32), P < 0.000 01], increase clin. efficiency [RR = 1.26, 95%CI(1.17, 1.35), P < 0.000 01], reduce the number of angina attacks [SMD =-2.38, 95%CI(-2.64, -2.11), P < 0.000 01], duration of angina pectoris [SMD =-3.40, 95%CI(-4.10, -2.70), P < 0.000 01], increase SAQ scores [MD = 14.15, 95%CI(11.69, 16.60), P < 0.000 01], improve the efficacy of ECG [RR = 1.20, 95%CI(1.05, 1.38), P = 0.009], reduce whole blood viscosity level [MD =-2.23, 95%CI(-3.28, -1.18), P < 0.000 1]. In the incidence of adverse reactions, there was no significant difference between the two groups [OR = 0.58, 95%CI(0.21, 1.59), P = 0.29]. Conclusion Compared with chem. drug alone, the combination of YQFM and chem. drug can reduce the incidence of cardiovascular events, improve the clin. effective rate, reduce the number of angina attacks and angina duration, improve the curative effect of ECG, SAQ scores, and hemorheol. and has no obvious adverse reactions. The above research results still need to be verified by more multicenter randomized controlled trials.