Delving into the Latest Updates on Kuhnil Pharma Co., Ltd. with Synapse

Overview

Tags

Endocrinology and Metabolic Disease

Cardiovascular Diseases

Nervous System Diseases

Small molecule drug

Chemical drugs

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Endocrinology and Metabolic Disease	10
Infectious Diseases	1
Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	14
Chemical drugs	4

Top 5 Target	Count

HMG-CoA reductase x Lipid x Triglyceride	1

BACKGROUNDAlopecia areata (AA) is characterized by rapid and complete hair loss in one or multiple areas of the scalp. Stress is an important triggering factor in AA.AIMTo identify the inhibitory effect of tianeptine on catagen induction in C57BL/6 mice with AA-like lesions induced by ultrasonic wave stress (UWS).METHODSThe mice were divided into four groups. Group 1 received oral tianeptine before and after UWS; group 2 received oral tianeptine only after UWS; group 3 was given UWS treatment only; and group 4 (negative control group) was not given any treatment. Phototrichigraphy and dermatoscopy were used for assessment. Histological analysis was performed using haematoxylin and eosin, toluidine blue, Masson trichrome and Verhoeff-van Gieson stains. Immunohistochemical analysis was also performed. The level of apoptosis and expression of neuropeptides in the skin were assessed by terminal deoxynucleotidyl transferase dUTP nick end labelling and immunofluorescence assays.RESULTSMice in group 1 had an increased rate of hair growth and greater hair-shaft thickness compared with mice in groups 2 and 3. In addition, mice in group 1 had a higher number of anagen hair follicles, increased synthesis of collagen and elastic fibres, decreased mast-cell degranulation, reduction in cell apoptosis in hair follicles, and recovery of vitamin D receptor expression. Expression of neuropeptides (substance P, calcitonin gene-related peptide) was not altered.CONCLUSIONSTianeptine might play a role in suppressing catagen induction in a stress-induced AA mouse model.

Yakhak Hoechi

Antimicrobial effect of the extract of Sophora flavescens Ait (I)

Author: Baek, Seung Hwa ; Yang, Eun Yeong ; Weon, Sung Ran ; Kim, Jong Soo ; Lee, Jeong Ho ; Kang, Kil Ung ; Cho, Hoon ; You, Il Soo ; Ru, Do Gon

In order to develop a antimicrobial agent, dried Sophora flavescens Ait. was extracted with several solvents, and then antimicrobial activity was investigated.The minimal inhibitory concentration (MIC) of the extracted substance against microorganisms were also examinedAntimicrobial activity of the initial methanol extract from the sample was the strongest compared to those of other solvent extracts such as H₂O, n-hexane, chloroform, Et acetate and methanol.The methanol extract had strong growth inhibition activity against gram-pos. bacteria (MIC, 25-50 μg/mL) such as B. subtilis and S. aureus.Among gram-pos. bacteria tested, B. subtilis was the most susceptible to the extracted substance.The antimicrobial activity of the methanol extract from the sample had strong growth inhibition activity against gram-neg. bacteria such as P. aeruginosa (MIC, 25 μg/mL).

100 Deals associated with Kuhnil Pharma Co., Ltd.

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100 Translational Medicine associated with Kuhnil Pharma Co., Ltd.

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Pipeline

Pipeline Snapshot as of 22 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

14

4

Approved

Other

28

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

KI-0806	Sleep Initiation and Maintenance Disorders More	Approved
Rosuvastatin/Omega-3-Acid Ethyl Esters ( HMG-CoA reductase x Lipid x Triglyceride )	Dyslipidemias More	Approved
KI-1115	Iron Overload More	Approved
KI-0401	Infectious Diseases More	Approved
KI-1120	Decreased libido More	Preclinical