Delving into the Latest Updates on Shaanxi Pharmaceutical Holding Group New Drug Technology Development Co., Ltd. with Synapse

Overview

Tags

Nervous System Diseases

Cardiovascular Diseases

Herbal medicine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

No Data

Disease Domain	Count

Nervous System Diseases	1

Top 5 Drug Type	Count

Herbal medicine	1

[Objective] To screen human tumor cell lines sensitive to syringin, and study its anticancer mechanism.[Method] To determine the inhibitory effect of syringin in vitro using tetrazolium salt (MTT) assay, and study the role of apoptosis pathway by assay of Caspase-3 activity.[Result] Among the 15 common human tumor cell lines, syringin IC₅₀ of hepatoma cell HepG2 and prostate cancer cell PC-3 were below 100 μg/m L. Syringin can promote the activity of Caspase-3 in tumor cells.[Conclusion] Hepatoma cell HepG2 and prostate cancer cell PC-3 are more sensitive to syringin, and the inhibition of syringin presents a dose-dependent manner.The cell apoptosis pathway plays a role in the anticancer activity of syringin.

Anhui Nongye Kexue

Comparison of the methods for the determination of sialic acid by hplc, enzymatic and resorcinol methods

Author: Zhu, Ai-hua ; Qin, Qiu-hong

[Objective] The research aimed to determine the accuracy, sensitivity and linearity of sialic acid concentration by high performance liquid chromatog. (HPLC), enzymic and resorcinol methods,and discuss the practical application characteristics of the three methods.[Method] Establishing methods for the determination of sialic acid concentration by HPLC, enzymic and resorcinol methods,and determining the sialic acid concentration in the same biol. products using the three methods.[Result] The linear range of HPLC method was 0.3-2 500.0 μg/mL, and the recovery rate was 98.0%-99.2%, within-day and day-to-day RSD were 0.8%-1.4% and 1.6%-1.8% resp.The linear range of enzymic method was 0.6-20.0 μg/mL, and the recovery rate was 102.0%-106.5%, within-day and day-to-day RSD were 3.5%-4.2% and 4.0%-4.6% resp.The calibration curve of resorcinol method was 39-1250 μg/mL, and the recovery rate was 98.2%-100.2%, Within-day and day-to-day RSD were 2.9%-3.3% and 3.0%-3.5% resp.[Conclusion] There is no significant difference among the three methods in terms of recovery and precision, but HPLC is more simple, convenient, inexpensive, sensitive, and has a wide linear range, which can be widely used for the determination of sialic acid in biol. products.

Zhongguo Yaoye

Research on dissolution determination method of golden buckwheat tablets

Author: Sun, Huang ; Bai, Zhengzhong ; Guo, Hongmei ; Wang, Zhongyan

The dissolution determination method of Chinese medicine solid preparations with Golden Buckwheat Tablets as the model drug was researched.The paddle method was adopted, 75 rpm/min, 0.25% sodium dodecyl sodium (SDS) 1000 mL as the dissolution medium, by using self-control, the dissolution was measured at the wavelength of 280 nm by UV method.The established method has high resolution and good reproducibility.The establishment of the dissolution method of Chinese medicine solid preparation has important significance.

100 Deals associated with Shaanxi Pharmaceutical Holding Group New Drug Technology Development Co., Ltd.

Login to view more data

100 Translational Medicine associated with Shaanxi Pharmaceutical Holding Group New Drug Technology Development Co., Ltd.

Login to view more data

Corporation Tree

Boost your research with our corporation tree data.

login

or

view full example data

Boost your research with our corporation tree data.

Pipeline

Pipeline Snapshot as of 14 Dec 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 3 Clinical

1

Login to view more data