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ABSTRACTWe conducted research studies on avian reovirus (ARV) infectivity in egg-laying hens, focusing on three variants (δC genotypes 2, 3, and 5) detected in layer chickens in Pennsylvania to date. Day-old chicks (Hy-Line North America, LLC, PA), raised at the Poultry Education and Research Center of Penn State University Park campus, showed healthy growth and normal egg production after 20 weeks of age. ARV variants were propagated in Leghorn male-chicken hepatocellular-carcinoma cell cultures, with concentrations measured at TCID₅₀/ml. Each group of 10 hens received a 1.0 ml dose containing 10³-10⁴ TCID₅₀/ml of one ARV variant through oral, nasal, and ocular routes. Infected hens showed normal egg production, with minimal signs of watery droppings in the first-week post-inoculation (pi). Cloacal and oral pharyngeal swabs were collected daily in the first week pi and every other day in the second-week pi to monitor virus shedding. Virus shedding began 24 h pi through faeces, peaked at 2-4 days pi, decreased by 5-7 days pi, and ceased after 12-14 days pi. A few birds' oral pharyngeal swabs were weakly positive for 1-3 days pi, then all turned negative. Infected hens developed high serum and egg yolk antibody titres at 2-3 weeks pi, showing 100% protection against subsequent infections with the same variant strain, demonstrating a 100% protection rate.RESEARCH HIGHLIGHTSAvian reovirus-infected hens shed virus heavily at 2-3 days post-inoculation.Shedding became minimal after 5-7 days post-inoculation.ARV variants offered 100% protection in hens upon subsequent infections.Infected hens maintained normal egg production with no observable clinical signs.

01 May 2025·Virology

Comprehensive single-cell profiling of T and B cell subsets in mice reveals impacts on memory immune responses in FMDV infection

Article

Author: Zhao, Wei ; Gao, Jie ; Lv, Daiyue ; Su, Jia ; Liu, Dongdong ; Bai, Hongxu ; Du, Jige ; Xue, Qinghong ; Wang, Guohua ; Chen, Xiaochun

The impact of Foot-and-Mouth Disease Virus (FMDV) on memory immune responses has not been thoroughly investigated due to limited availability of immunological research tools. Using single-cell RNA sequencing, we identified specific gene markers for the majority of T and B cell subsets in the spleens of mice. Our findings indicate that FMDV infection significantly reduces the proportions of memory cell populations (e.g., memory B cells, memory CD4⁺ T cells, and memory CD8⁺ T cells) relative to their respective lymphocyte subsets (total B cells, CD4⁺ T cells, and CD8⁺ T cells) in the short term, impacting their functions. These alterations largely reverse over the long term. Specifically, FMDV infection primarily exerts its impacts on the function of memory cells by enhancing key immunological functions such as activation, proliferation, differentiation, and polarization, while simultaneously suppressing essential cellular biological functions including proliferation and metabolism. These impacts were significantly associated with Fos-related genes. Our study provides new insights into the immune evasion mechanisms of FMDV, establishes adult mice as potential models for FMDV immunological research, and offers valuable tools for single-cell RNA sequencing in murine immunological studies.

01 Mar 2025·Virus Research

Pathogenicity of avian reovirus variant in the immune organs of broiler chicks

Article

Author: Diao, Youxiang ; Wu, Qiong ; Wang, You ; Tang, Yi ; Zhu, Yudong ; Yu, Haiyang ; Lu, Huaguang ; Zhao, Wanjun ; Wang, Dong ; Li, Yijing

In recent years, the infection rate of avian reovirus (ARV) in chicks has been continuously increasing, seriously endangering the healthy development of China's chicken farming industry. However, the pathogenicity of this virus in immune organs has been less studied. In this study, an ARV strain (Chicken/XJ/China/2022/01/16) was isolated from arthritic broiler chicks in Xinjiang province and whole genome sequencing of the ARV strain was performed using next generation sequencing (NGS) technology, and sequence analysis showed that the strain was a type V variant of the ARV gene. In order to further understand the pathogenicity of this strain in terms of immune organs, we randomized 120 healthy 1-day-old broilers equally into 3 groups (oral, footpad inoculation and control), where 2 experimental groups were inoculated with 0.2 mL of ARV (TCID₅₀ of 10^5.5 /0.1 mL) and the control group was inoculated with an equal amount of sterile saline. The results showed that the footpad inoculation group showed more severe symptoms, which, in addition to causing chick dwarf syndrome and viral arthritis, would also cause serious effects on the immune organs of the chicks. Among them, the spleen and bursa were most seriously damaged, the symptoms of arthritis appeared relatively late, which indicated that the spleen and bursa might be the main target organs preferentially attacked by avian reovirus. This study provides a rationale for the prevention and control of emerging avian reovirus and adds to the evidence of the effects of ARV on immune organs, with the expectation that it will be useful in understanding the immune response-related aspects of the disease in subsequent studies.

100 Deals associated with Tianjin Ringpu Bio-technology Co., Ltd.

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100 Translational Medicine associated with Tianjin Ringpu Bio-technology Co., Ltd.

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Pipeline

Pipeline Snapshot as of 13 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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