Delving into the Latest Updates on Medea Research with Synapse

Overview

Dextran and insulin conjugates as drug carriers are prepared via periodate oxidation, formation of azide derivatives, activation by cyanogen halides or organic cyanates or formation of bromo- or chlorohydroxypropyl derivatives and conjugation with drugs.The stability and pharmacol. properties of these conjugates are discussed.

Alfred Benzon Symposium

Effects of the polysaccharidic carrier on the kinetic fate of drugs linked to dextran and inulin in macromolecular compounds

Author: Molteni, L.

A review and discussion with 15 references of the use of dextran [9004-54-0] and inulin [9005-80-5] as carriers for drugs, and how they modify the pharmacokinetics of some drugs.

Arzneimittel-Forschung

MR 714, a new aryloxypropionic nonsteroidal antiinflammatory agent. Chemical and pharmacokinetic properties and preliminary pharmacotoxicological data

Author: Borrelli, G. ; Marzo, A. ; Reali, F. L. ; Stradi, R. ; Bruno, G. ; Treffner, E. ; Quadro, G.

MR 714 (I) [98496-95-8] has analgesic and antiinflammatory activity, while gastroulcerogenetic action is virtually absent.MR 714 orally administered to mice gave an LD₅₀ of 848 mg/kg; the drug had little effect on general behavior, food and water intake, or diuresis after single or repeated administration.An autoptic examination after single oral doses (25, 50, 100 and 200 mg/kg) or repeated oral doses (100 mg/kg/day over 5 days) did not show any adverse modification and no mutagenic action was detected using the Ames test.MR 714 given orally to rats was absorbed excellently and plasma levels showed a peak after 4-6 h, followed by a plateau lasting 24-36 h at a dose of 50 or 100 mg/kg and considerably less at a dosage of 25 mg/kg.For the lower dose, a plasma half-life (t_1/2) of 13 h was determinedExcretion occurred only via the bile in conjugated form (acylglucuronide) which reverted easily into the parent drug.The resultant enterohepatic circulation contributes to a substantial maintenance of plasma levels and hence long-lasting activity.Among the organs examined, the uterus showed the highest ratio of organ/plasma concentration; this evidence points to a possible clin. application of MR 714 in the treatment of dysmenorrhea.

100 Deals associated with Medea Research

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100 Translational Medicine associated with Medea Research

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Pipeline

Pipeline Snapshot as of 05 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

MR-708 ( DRDs )	Depressive Disorder, Major More	Discontinued
Midesteine ( ELA2 )	Pulmonary Emphysema More	Discontinued
Tenosal ( COX )	Pain More	Pending
MR-14134 ( calcium channel )	Hypertension More	Pending