Delving into the Latest Updates on Epigenesis Pharmaceuticals LLC with Synapse

Overview

Basic Info

Introduction

Epigenesis Pharmaceuticals is a company specializing in the development of inhaled respiratory medications. Their products are designed to treat conditions such as asthma, obstructive pulmonary disease, and other respiratory illnesses. Founded by Jonathan W. Nyce in 1995, the company is based in Cranbury, New Jersey.

The extensive role of adenosine in discriminating input from the extracellular environment is effected through a series of cell membrane-spanning proteins--the adenosine A1, A2A, A2B and A3 receptors. New genetic and epigenetic tools have emerged that facilitate the elucidation of the function of these receptors with greater specificity than is generally possible with traditional antagonist drugs. These tools include antisense oligonucleotides (epigenetic) and gene 'knockin' and 'knockout' mice (genetic) and are discussed in this article by Jonathan Nyce.

01 Apr 1997·Mutation Research/Reviews in Mutation Research

Drug-induced DNA hypermethylation: A potential mediator of acquired drug resistance during cancer chemotherapy

Review

Author: Nyce, J W

A review with 60 references

100 Deals associated with Epigenesis Pharmaceuticals LLC

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100 Translational Medicine associated with Epigenesis Pharmaceuticals LLC

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Pipeline

Pipeline Snapshot as of 25 Jul 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

EPI-12322 ( ADA )	Asthma More	Discontinued
Durason ( A1R )	Asthma More	Discontinued
Naturasone ( Adenosine receptor )	Rhinitis, Allergic More	Discontinued
EPI-15001	Pulmonary Disease, Chronic Obstructive More	Pending
EPI-4067	Asthma More	Pending