Delving into the Latest Updates on China Gateway Biologics (Shanghai) Co., Ltd. with Synapse

Overview

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Neoplasms

Bispecific antibody

Disease domain score

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Technology Platform

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Targets

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Disease Domain	Count

Neoplasms	1

Top 5 Drug Type	Count

Bispecific antibody	1

Top 5 Target	Count

CD47 x PDL1	1

主要目的： 1) 评估注射用SG12473 在晚期恶性肿瘤患者中的安全性和耐受性； 2) 确定注射用SG12473 静脉给药在晚期恶性肿瘤患者中的最大耐受剂量（MTD）和/或II 期推荐剂量（RP2D）（Ia 期）。次要目的： 1) 评估注射用SG12473 在晚期恶性肿瘤患者中的药代动力学特征； 2) 评估注射用SG12473 在晚期恶性肿瘤患者中的药效动力学特征； 3) 评估注射用SG12473 在晚期恶性肿瘤患者中的免疫原性； 4) 初步评价注射用SG12473 在晚期恶性肿瘤患者中的疗效。探索性目的：探索肿瘤组织/血液中潜在预测注射用SG12473 疗效的生物标志物。

[Translation]

Primary objectives: 1) To evaluate the safety and tolerability of SG12473 for injection in patients with advanced malignancies; 2) To determine the maximum tolerated dose (MTD) and/or recommended phase II dose (RP2D) (Phase Ia) of SG12473 for injection for intravenous administration in patients with advanced malignancies. Secondary objectives: 1) To evaluate the pharmacokinetic characteristics of SG12473 for injection in patients with advanced malignancies; 2) To evaluate the pharmacodynamic characteristics of SG12473 for injection in patients with advanced malignancies; 3) To evaluate the immunogenicity of SG12473 for injection in patients with advanced malignancies; 4) To preliminarily evaluate the efficacy of SG12473 for injection in patients with advanced malignancies. Exploratory objectives: To explore biomarkers in tumor tissue/blood that may potentially predict the efficacy of SG12473 for injection.

Start Date01 Jul 2021

Sponsor / Collaborator

China Gateway Biologics (Shanghai) Co., Ltd.

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100 Clinical Results associated with China Gateway Biologics (Shanghai) Co., Ltd.

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0 Patents (Medical) associated with China Gateway Biologics (Shanghai) Co., Ltd.

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100 Deals associated with China Gateway Biologics (Shanghai) Co., Ltd.

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100 Translational Medicine associated with China Gateway Biologics (Shanghai) Co., Ltd.

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Pipeline

Pipeline Snapshot as of 24 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1 Clinical

1

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