OBJECTIVE To establish gas chromatog. method for the determination of impurity-1-chloroethyl acetate in flurbiprofen axetil. METHODS The method was performed on a capillary chromatog. column (DB-1 30 m×0.32 mm, 1.00 μm). The programmed temperature was applied: The column temperature was 80°C (maintained for 2 min), then raised to 100°C (maintained for 4 min) at the rate of 5°C·min-1. FID was used as detector at the temperature of 250°C with the inlet temperature setting at 200°C. Carrier gas was nitrogen with a flow rate of 1 mL·min-1. The injection volume was 1 μL. RESULTS The linearity regression equation of 1-chloroethyl acetate was y=0.919 x+0.0467 (r=0.9994) in the range of 0.61-9.08 μg·mL-1. The recovery ranged from 98.89% to 109.35%, with an average recovery of 102.8% (RSD=3.4%). Precision, quant. limit, detection limit, stability of the solution, durability tests had been verified with good results.1-Chloroethyl acetate was an intermediate in producing flurbiprofen axe til, whose content was much less than the limit in the unpurified flurbiprofen are til. Besides, 1-chloroethyl acetate was not detected in purified flurbiprofen axetil. CONCLUSION The method is simple to operate with good reproducibility and high sensitivity, which meet the requirements for the determination of chloroethanol acetate in flurbiprofen axe til.