First-in-Human Early Feasibility Clinical Evaluation of Safety, Efficacy and Utility of the Cook® Venous Valve System for Treatment of Chronic Venous Insufficiency

The purpose of this study is to learn about the safety, efficacy and utility of a medical device called the Cook® Venous Valve System. This device, percutaneously placed in the leg, is meant to help the blood flow correctly through the veins in the leg.

Start Date24 Apr 2023

Sponsor / Collaborator

MED Institute, Inc.

NCT04222166

/ CompletedNot Applicable

Registry of Amniotic Membrane: Evaluating Utilization and Outcomes in Various Applications

This registry will assess clinical outcomes following the use of Cryopreserved Amniotic Membrane (CAM) for the treatment of orthopedic and various other conditions. This registry will collect outcomes data via a registry of up to 100 patients who have received treatment with CAM in the post-market setting. Patients will be enrolled from up to five healthcare centers.

Start Date16 Dec 2019

Sponsor / Collaborator

MED Institute, Inc.

NCT00487552

/ TerminatedNot Applicable

Endoscopic Gastroenteric Anastomosis Formed by Magnetic Compression and Stent Placement for Palliation of Malignant Gastric Outlet Obstruction

The purpose of this study is to determine if the Cook Magnetic Anastomosis Device can be used to safely and successfully create a patent gastrojejunal anastomosis in subjects requiring treatment of gastric outlet obstruction caused by malignancy.

Start Date01 Jan 2008

Sponsor / Collaborator

Cook Group, Inc.

[+2]

100 Clinical Results associated with MED Institute, Inc.

0 Patents (Medical) associated with MED Institute, Inc.

5,783

Literatures (Medical) associated with MED Institute, Inc.

01 Jan 2025·Journal of Cardiovascular Magnetic Resonance

Feasibility of magnetic resonance imaging-guided cardiac catheterization, angioplasty, and stenting in a commercial wide-bore 0.55T scanner

Article

Author: Ooms, Nathan ; Simonetti, Orlando P ; Bramwell, Orville ; Pang, Jianing ; Armstrong, Aimee K ; Krishnamurthy, Ramkumar ; Joseph, Matthew ; Kelly, John M ; Maier, Florian ; Krieger, Joshua ; Swinning, Jason ; Borm, Paul ; Liu, Yixuan ; Jin, Ning ; Roll, Jesse ; Mos, Lucien de ; Liu, Yingmin ; Gross, David C ; Krafft, Axel J

BACKGROUNDLow-field (0.55T) magnetic resonance imaging (MRI) may allow MRI-guided interventions using available catheterization equipment, as radiofrequency-induced heating of interventional devices is reduced at low field. The purpose of this study was to test the feasibility of real-time MRI-guided right and left heart catheterization (R&LHC) as well as angioplasty and stenting of the inferior vena cava using a commercially available 0.55T MRI system (MAGNETOM Free.Max, Siemens Healthineers AG, Erlangen, Germany) with 80 cm patient bore and maximum gradient amplitude and slew rate of 26 mT/m and 45 mT/m/ms, respectively. A secondary aim was to evaluate three different sizes of magnetic resonance (MR)-visible markers.METHODSSheaths were placed in the femoral vein and artery of juvenile Yorkshire pigs under general anesthesia. Air-filled balloon wedge catheters and Judkins right catheters were used for R&LHC, respectively, aided by an MR-compatible guidewire. Ferumoxytol was administered as a T1-shortening contrast agent and real-time visualization was carried out with a research interactive sequence using different spatiotemporal resolution settings. IVC angioplasty was performed using balloons filled with 1% gadolinium, and IVC stenting was performed with stainless-steel stents and one platinum-iridium-covered sten.RESULTSRHC was successful in all eight attempts with balloon tip visibility in all real-time protocols. One pig expired with ferumoxytol infusion, but the catheterization was completed post-mortem. LHC and IVC angioplasty were attempted and successful in two and four pigs, respectively. For stenting, higher resolution, lower frame rate imaging was used. All six attempted stent implantations were successful. The MR markers on the angioplasty balloon with widths of 0.5 and 1 mm were more visible than the 0.25 mm markers. Marker placement affected distinguishability from the crimped stent. Stainless-steel stents created only minimal signal voids pre- and post-deployment; however, the platinum-iridium stent caused significant artifact obscuring wall apposition assessment.CONCLUSIONThis study is the first to demonstrate the technical feasibility of R&LHC, IVC angioplasty, and IVC stenting using real-time MRI on a commercially available low-field scanner.

05 Mar 2024·Analytical Chemistry

Online and Offline Prioritization of Chemicals of Interest in Suspect Screening and Non-targeted Screening with High-Resolution Mass Spectrometry

Review

Author: Kruve, Anneli ; Williams, Antony J ; Vas, Gyorgy ; Phillips, Allison L ; Falconer, Travis M ; Szabo, Drew ; Heise, Ted ; Fisher, Christine M

Recent advances in high-resolution mass spectrometry (HRMS) have enabled the detection of thousands of chemicals from a single sample, while computational methods have improved the identification and quantification of these chemicals in the absence of reference standards typically required in targeted analysis. However, to determine the presence of chemicals of interest that may pose an overall impact on ecological and human health, prioritization strategies must be used to effectively and efficiently highlight chemicals for further investigation. Prioritization can be based on a chemical's physicochemical properties, structure, exposure, and toxicity, in addition to its regulatory status. This Perspective aims to provide a framework for the strategies used for chemical prioritization that can be implemented to facilitate high-quality research and communication of results. These strategies are categorized as either "online" or "offline" prioritization techniques. Online prioritization techniques trigger the isolation and fragmentation of ions from the low-energy mass spectra in real time, with user-defined parameters. Offline prioritization techniques, in contrast, highlight chemicals of interest after the data has been acquired; detected features can be filtered and ranked based on the relative abundance or the predicted structure, toxicity, and concentration imputed from the tandem mass spectrum (MS²). Here we provide an overview of these prioritization techniques and how they have been successfully implemented and reported in the literature to find chemicals of elevated risk to human and ecological environments. A complete list of software and tools is available from https://nontargetedanalysis.org/.

26 Oct 2023·Biomedical physics & engineering express

Computational modeling of the thermal effects of flow on radio frequency-induced heating of peripheral vascular stents during MRI.

Article

Author: Gross, David C ; Simonetti, Orlando P ; Leewood, Alan R ; Scandling, Benjamin W

Purpose. The goal of this study was to develop and validate a computational model that can accurately predict the influence of flow on the temperature rise near a peripheral vascular stent during magnetic resonance imaging (MRI).Methods. Computational modeling and simulation of radio frequency (RF) induced heating of a vascular stent during MRI at 3.0 T was developed and validated with flow phantom experiments. The maximum temperature rise of the stent was measured as a function of physiologically relevant flow rates.Results. A significant difference was not identified between the experiment and simulation (P > 0.05). The temperature rise of the stent during MRI was over 10 °C without flow, and was reduced by 5 °C with a flow rate of only 58 ml min^-1, corresponding to a reduction of CEM₄₃from 45 min to less than 1 min.Conclusion. The computer model developed in this study was validated with experimental measurements, and accurately predicted the influence of flow on the RF-induced temperature rise of a vascular stent during MRI. Furthermore, the results of this study demonstrate that relatively low flow rates significantly reduce the temperature rise of a stent and the surrounding medium during RF-induced heating under typical scanning power and physiologically relevant conditions.

100 Deals associated with MED Institute, Inc.

100 Translational Medicine associated with MED Institute, Inc.

Corporation Tree

Boost your research with our corporation tree data.

view full example data

Pipeline

Pipeline Snapshot as of 22 May 2025

No data posted

Deal

Boost your decision using our deal data.

view full example data

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Profit

Explore the financial positions of over 360K organizations with Synapse.

view full example data

Grant & Funding(NIH)

Access more than 2 million grant and funding information to elevate your research journey.

view full example data

Investment

Gain insights on the latest company investments from start-ups to established corporations.

view full example data

Financing

Unearth financing trends to validate and advance investment opportunities.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

MED Institute, Inc.

Overview

Related

Corporation Tree

Pipeline

Pipeline Snapshot as of 22 May 2025

Deal

Translational Medicine

Profit

Grant & Funding(NIH)

Investment

Financing