Objective: To optimize the extraction technol. for Qingremingmu Capsule.Methods: The orthogonal test design was used to test the main factors of extraction process, including the amount of water, decocting time and decocting operation frequency, and the amount of paeoniflorin extraction was used as guide.Results: The optimum condition was adding 8 times amount of water for decocting three times and each time for 1 h.Conclusion: The extraction process is reasonable, which provides the scientific basis for the preparation of Qingremingmu Capsule.