Delving into the Latest Updates on Sopharmia, Inc. with Synapse

Overview

Tags

Infectious Diseases

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Infectious Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1

Top 5 Target	Count

β-lactamase(Beta Lactamase)	1

Antibiotic resistance is a worsening global pandemic regarded by the World Health Organization as one of the greatest threats to human health.For bacteria, the most prevalent and important method of resisting antibiotics is through the production of β-lactamase enzymes that inactivate β-lactam antibiotics before they can elicit their bactericidal effects.Because of the growing numbers of inhibitor-resistant β-lactamases, the discovery of new β-lactamase inhibitors represents an urgent, unmet medical need.Finding inhibitors of metallo-β-lactamases (MβL) is particularly challenging because these enzymes do not form covalent, acylated enzyme intermediates required for currently approved and in development inhibitors to inactivate serine-β-lactamases.Characterization of the time-dependent inhibition of metallo-β-lactamases by the title cephalosporin, dubbed S104, is described.Incubation of S104 with NDM-1, VIM-2, and IMP-1 MβLs in 100 mM pH 7.0 Tris buffer containing 100 mM ZnCl₂ results in 83%, 81%, and 64% inhibition, resp. and ten minute IC₅₀values in the micromolar range.The kinetic inactivation profile appears biphasic, with initial rapid inactivation followed by slower inactivation.A proposed mechanism will be discussed and supported based upon known ligand-MβL active site structures.

100 Deals associated with Sopharmia, Inc.

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100 Translational Medicine associated with Sopharmia, Inc.

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Pipeline

Pipeline Snapshot as of 09 Aug 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

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