Matrivax Research & Development Corp.

BOSTON, June 16, 2025 /PRNewswire/ -- Solu Therapeutics, a biotechnology company pioneering novel therapies to eliminate disease-driving cells in cancer, immunology, and other therapeutic areas, today announced the appointment of Enda Moran, PhD, MBA as Chief Operating Officer (COO). "As we advance our Phase 1 clinical trial of STX-0712 in patients with resistant/refractory chronic myelomonocytic leukemia (CMML) and other hematologic malignancies, Enda brings outstanding experience in large-scale biomanufacturing and company operations to our leadership team," said Philip J. Vickers, President and CEO of Solu Therapeutics. "His expertise in scaling biologic therapeutics and guiding early-stage programs through development will be instrumental as we grow and work to deliver transformative therapies for patients living with cancer, immunological diseases and other serious illnesses." As COO, Dr. Moran will lead core operational functions at Solu including chemistry manufacturing and controls (CMC), quality, program management, IT, and facilities management. He will also play a key role in building the infrastructure needed to support Solu's CyTAC™ (Cytotoxicity Targeting Chimera) and TicTAC™ (Therapeutic Index Control Targeting Chimera) platforms as the company progresses toward multiple clinical and regulatory milestones. "I am very excited to join the Solu Therapeutics team at this pivotal moment as the company moves into a new phase of growth," said Dr. Moran. "The CyTAC and TicTAC platforms are rooted in strong science and have the potential to change the landscape for patients who are desperately in need of new treatment options. I look forward to applying my experience to maximize the potential of these platforms and bring a new generation of innovative therapies to the patients who need them most." Dr. Moran has over three decades of experience leading biomanufacturing and technical development across pharma and biotech. He previously held senior scientific roles at GSK and Wyeth before joining Pfizer as Senior Director of Biomanufacturing, where he led global teams supporting the development and production of successful commercial therapies including Enbrel®, Trumenba®, Xyntha®, and the Prevnar®13 vaccine. He later joined Northern Biologics as Vice President and Head of CMC and Manufacturing, where he was instrumental in advancing multiple development programs and enabling the strategic acquisition of assets by AstraZeneca and Boehringer Ingelheim. Most recently, he served as CEO of Matrivax, leading a successful corporate restructuring and completion of a Phase 1 clinical trial. About Solu Therapeutics Solu Therapeutics is a biotechnology company cofounded by Longwood Fund and committed to developing an innovative class of therapeutic agents that uniquely pair small molecules with monoclonal antibodies to eliminate disease-driving cells in cancer, immunology, and other therapeutic areas. By leveraging its proprietary CyTAC (Cytotoxicity Targeting Chimera) and TicTAC (Therapeutic Index Control Targeting Chimera) platforms, Solu is advancing therapies that combine the target-binding capability of small molecules with the therapeutic power of biologics. Our lead product candidate, STX-0712, is currently in Phase 1 clinical development for the treatment of advanced hematologic malignancies including CMML. For more information, visit . Media Contact Holly Stevens [email protected] CG Life SOURCE Solu Therapeutics WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

First participant dosed in a Phase 1 clinical evaluation of a fusion protein vaccine designed to provide ‘serotype-independent’ protection against disease caused by multiple Streptococcus pneumoniae serotypes BOSTON--(BUSINESS WIRE)-- Vaccine development company Matrivax announces the start of its Phase 1 clinical study to assess the safety, tolerability, and immunogenicity of its lead pneumococcal disease vaccine candidate, MVX01. Streptococcus pneumoniae is the primary bacterial cause of community-acquired pneumonia and meningitis, and a significant cause of otitis media, sinusitis, and bacteremia. Pneumococcal disease continues to be a major global public health concern causing greater than 1 million deaths worldwide annually, with a substantial proportion of fatalities among the elderly and immunocompromised, and in children populations less than 5 years old in Asian and African countries. MVX01 is a fusion protein of two highly conserved protein antigens across Streptococcus pneumoniae bacterial serotypes: a genetically inactivated form of the virulence factor, pneumolysin toxin, and two epitopes from the cell surface protein, choline binding protein A. “This Phase 1 study is an exciting milestone for Matrivax, and a major step forward in the development of a vaccine that has potential to be a technological breakthrough in vaccination options against pneumococcal disease,” said Enda Moran, Chief Executive Officer of Matrivax. “While there are effective vaccines currently available, they are very expensive to the end-user, and they don’t protect against all the bacterial serotypes that can cause disease. Our low-cost manufacturing platform and the prospect of a single-component, broad-coverage vaccine can translate directly into a much needed low-cost vaccine for pneumococcal disease.” Kevin Killeen, Chief Scientific Officer of Matrivax, added, “Our preclinical data clearly demonstrate that MVX01 effectively immunizes and protects against a broad range of S. pneumoniae bacterial serotypes, including the serotypes covered by the leading commercial 20-valent conjugate vaccine. We’ve engineered the vaccine to present antigens to the vaccinee that are highly conserved across the >100 wild-type serotypes that cause pneumococcal disease. This vaccine candidate provides the real opportunity of a vaccine that can immunize against the broad spectrum of disease-causing strains. We are delighted to now start clinical development of the vaccine in human subjects with our clinical research partner, FHI Clinical.” About the MVX01 Phase 1 Study The Phase 1 study will be executed at two US clinical sites and will evaluate the safety, tolerability, and immunogenicity of the MVX01 vaccine candidate in healthy volunteers aged 18-75 years. Participants will be separated to 5 cohorts with the dose level of MVX01 being sequentially escalated across cohorts ranging from concentrations of 10 μg/dose to 90 μg/dose. Participants within cohorts will receive two doses about a month apart, of either placebo or MVX01 vaccine. Participants will be monitored and assessed throughout the study and for approximately 6.5 months after the booster dose. Immunogenicity will be evaluated by measuring serum antigen-specific IgG antibody titers. About Matrivax Matrivax is a privately-held biotechnology company funded by Morningside Investments and based in the biotech hub of Boston, MA, USA. The company is developing human vaccine candidates for the prevention and treatment of life-threatening infectious diseases. The pipeline includes two vaccine candidates implementing proprietary protective antigens against Streptococcus pneumoniae (MVX01) and Clostridioides difficile (MVX02). For more information, visit .