Roche China Holding Ltd.

Roche will unveil the next generation of its serum work area, several molecular systems and the cobas® connection module. The company will introduce navify® digital solutions that help laboratories address their needs for digital infrastructure, operational excellence and medical insights. Attendees can experience an integrated lab that goes beyond simply connecting individual technologies to demonstrate true end-to-end operational excellence. ROTKREUZ, Switzerland, May 17, 2023 /PRNewswire/ -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that it will be showcasing innovative laboratory solutions and digital diagnostics through - "Innovation Past, Present and Future" at this year's WorldLab-EuroMedLab 2023 in Rome, Italy, 21-25 May. Attendees will have the opportunity to experience first-hand Roche's latest technological advancements in lab automation, serum work area, molecular and point of care solutions and find out more about how the company is transforming patient care through advancements in breakthrough high-medical value diagnostic and digital solutions. "With the ever-changing needs of the healthcare system, laboratories and clinicians are expected to optimise laboratory operations and efficiencies while improving patient care," said Ann Costello, Head of Roche Diagnostics Solutions at Roche Diagnostics. "We are pleased to present the next generation of innovative solutions that simplify and streamline testing for laboratories of all sizes, throughputs and disciplines, while supporting clinical decision-making to improve patient care." "Laboratories have a unique opportunity to connect siloed data across systems and points of care for greater insights," said Moritz Hartmann, Head of Roche Information Solutions at Roche Diagnostics. "At Roche, we are working closely together with lab leaders to enable more patient-centred care. Our navify® portfolio of integrated digital solutions enables open digital ecosystems that connect to innovations, drive operational efficiencies and generate actionable insights for improved patient care." Roche will be featuring new innovations, such as several molecular systems from the growing PCR portfolio – the cobas® 5800 and the new LightCycler® PRO System, launching later this year. A prototype for the new cobas® Mass Spec system will be revealed, bringing mass spectrometry into the routine testing environment. The system will complement the serum work area portfolio so that in the future, healthcare communities will benefit from an extended diagnostic platform offering clinical chemistry, heterogeneous immunoassays, and mass spectrometry. The new cobas® connection modules (CCM Vertical), a flexible modular system that uses lab space effectively, and seamlessly integrates into the existing cobas® connection modules, improving lab efficiency, will also be featured*. Roche will also introduce its navify digital solutions to the laboratory community. navify digital solutions aim to solve laboratories' need for seamless and secure connectivity between systems, instruments and even devices from different providers as well as empowering lab leaders to drive operational efficiencies, and help clinicians gain greater medical insights. Attendees can also listen to industry experts discuss digital solutions, point of care, mass spectrometry, neurology and cyber security during in-booth talks. They can also tour a state-of-the-art innovation room showing the connected portfolio of point of care devices. For information on educational workshops and more visit diagnostics.roche.com. View the full EuroMedLab agenda for a complete list of Roche's presentations. *Not all of the before-mentioned instruments are approved or available for sale to customers. About Roche Founded in 1896 in Basel, Switzerland, as one of the first industrial manufacturers of branded medicines, Roche has grown into the world's largest biotechnology company and the global leader in in-vitro diagnostics. The company pursues scientific excellence to discover and develop medicines and diagnostics for improving and saving the lives of people around the world. We are a pioneer in personalised healthcare and want to further transform how healthcare is delivered to have an even greater impact. To provide the best care for each person we partner with many stakeholders and combine our strengths in Diagnostics and Pharma with data insights from the clinical practice. In recognising our endeavor to pursue a long-term perspective in all we do, Roche has been named one of the most sustainable companies in the pharmaceuticals industry by the Dow Jones Sustainability Indices for the thirteenth consecutive year. This distinction also reflects our efforts to improve access to healthcare together with local partners in every country we work. Genentech, in the United States, is a wholly owned member of the Roche Group. Roche is the majority shareholder in Chugai Pharmaceutical, Japan. For more information, please visit . All trademarks used or mentioned in this release are protected by law. For further information: Onsite: Jonathan Parry, Roche Diagnostics Communications Mobile: +41 79653 76 43 e-mail: [email protected] Monica Ryser, Roche information Solutions Mobile - 41 79 909 4099 email - [email protected] Offsite: Elizabeth Baxter, Roche Diagnostics Communications Mobile: +1 925-523-8812 e-mail: [email protected] SOURCE Roche Molecular Systems, Inc.

Method-of-use-patent covers KIN001 in ophthalmic diseasesFurther strengthens already granted KIN001 US composition of matter patent Basel, Switzerland, 22 November 2022. Kinarus Therapeutics Holding AG (SIX: KNRS) (“Kinarus”), a clinical-stage biopharmaceutical company developing novel therapeutics to treat viral, respiratory, and ophthalmic diseases, announced today the receipt of a Notice of Allowability from the United States Patent and Trademark Office (USPTO) for US Patent Application No. 16/500,504 “Methods of preventing or treating Ophthalmic Diseases “ covering its therapeutic candidate KIN001 in age-related macular degeneration (AMD). The method of use patent is on top of granted US Patent No. 11285155 that protects the KIN001 pharmaceutical combination of pamapimod and pioglitazone until at least 2037. The composition of matter protection afforded by Patent No. 11285155 is irrespective of therapeutic indication. Kinarus is currently developing KIN001 as an oral treatment for wet age-related macular degeneration, idiopathic pulmonary fibrosis, and Covid-19. Dr Alexander Bausch, Kinarus CEO, commented: “This USPTO allowance, together with the prior intellectual property secured by Kinarus in the US, EP, Australia, Eurasia, China, ARIPO and other countries, provides an even more secure IP protection for KIN001 in wet AMD and other retinal diseases. The positioning of KIN001 as an oral therapy in the ophthalmology space is unique. Our ambition is that KIN001 will be the first oral therapy used in combination with anti-VEGF therapies to stop progression of wet AMD and other retinal diseases in our aging population.” KIN001-AMD Phase 2 trial. KIN001 is under development as an oral therapy complementing current anti-VEGF drugs with the goal to extend the treatment interval between ocular injections. Kinarus has received regulatory approval to conduct a one-year Phase 2 clinical study in Switzerland and Germany. KIN001 is a combination of two active pharmaceutical ingredients (APIs): pamapimod and pioglitazone. Pamapimod is a highly selective clinical stage small molecule inhibitor of the p38 mitogen-activated protein kinase (p38 MAPK) signaling pathway. Kinarus has found that combining pamapimod with pioglitazone, a safe and well-tolerated marketed drug for the treatment of type 2 diabetes, leads to synergistic efficacy and increased duration of action in preclinical models of wet AMD, IPF and other fibrotic and inflammatory diseases. Kinarus Therapeutics Holding AG (www.kinarus.com) was founded in 2017 by experienced pharmaceutical executives. The Kinarus team utilizes its knowledge and drug development competencies to in-license and develop mid-stage clinical assets which have increased probability of clinical and regulatory success and a rapid path to market. Kinarus possesses the exclusive worldwide license to pamapimod from Roche Pharmaceuticals Ltd. covering all therapeutic indications. Contacts Kinarus Therapeutics Holding AGHochbergerstrasse 60C 4057 Basel, Switzerland+41 61 633 29 71info@kinarus.comInvestors & MediaChris MaggosBioConfidant Sàrl+41 79 367 6254maggos@bioconfidant.ch Legal disclaimer THIS PRESS RELEASE DOES NOT CONSTITUTE AN OFFER TO SELL NOR AN INTIMATION TO SUBMIT A PROPOSAL FOR THE ACQUISITION OF SECURITIES OF KINARUS THERAPEUTICS HOLDING AG. THIS PRESS RELEASE IS NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION, DIRECTLY OR INDIRECTLY, IN WHOLE OR IN PART, INTO OR WITHIN ANY JURISDICTION WHERE IT IS UNLAWFUL TO BE DISTRIBUTED.