Background: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2), is a causative agent of current global pandemic of Coronavirus disease-19 (COVID-19). Due to propagated outbreak and global vaccination drive an immense immunol. selection pressure has been exerted on SARS CoV-2 leading to evolution of new variants. This study was performed to compare the mutational and clin. profile of liver disease patients infected with different variants of SARS CoV-2. Methodol.: This was a single-center, retrospective, cohort study in which clinicogenomic anal. of liver disease (LD) patients infected with SARS CoV-2 was performed. Complete demog. and clin. details were retrieved from Hospital Information System (HIS). QC-threshold passed FASTA files containing sequences from COVID-19 patients (n = 174) were compared with a reference genome of SARS-CoV-2 isolate named Wuhan-Hu-1 (NCBI Reference Sequence: NC_045512.2) for mutational anal. Results: Out of 232 finally analyzed patients 137 (59.1%) were LD-CoV (+) and 95 (40.9%) were LD CoV(-). LD patients with comorbidities were affected more with COVID-19 (p = 0.002). On comparing the outcome in the terms of mortality, LD-CoV (+) had 2.29 times (OR 2.29, CI 95%, 1.25-4.29) higher of odds of succumbing to COVID-19 (p = 0.006). Multivariate regression anal. revealed, abdominal distention (p = 0.05), severe COVID-19 pneumonia (p = 0.046) and the change in serum bilirubin levels (p = 0.005) as well as Alk. phosphatase (ALP) levels (p = 0.003) to have an association with adverse outcome in LD patients with COVID-19. In Delta (22%) and Omicron (48%) groups, Spike gene harboured maximum mutations. On comparing the mutations between LD-CoV(+/D) and LD-CoV(+/O) a total of nine genes had more mutations in LD-CoV(+/O) whereas three genes had more mutations in LD-CoV(+/D). Conclusion: We concluded that LD patients are more susceptible to COVID-19 as compared to a healthy adult with associated adverse clin. outcomes in terms of mortality and morbidity. Therefore this special group should be given priority while devising and introducing new vaccination and vaccination policies. The infection with different variants did not result in different outcome in our group of patients.