Delving into the Latest Updates on INSA Rouen with Synapse

Overview

Tags

Immune System Diseases

Endocrinology and Metabolic Disease

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Endocrinology and Metabolic Disease	1
Immune System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1

Top 5 Target	Count

VCAM1(Vascular cell adhesion molecule 1)	1

AbstractThe study of Pd(0)‐catalyzed C−H bond arylation of methyl 5H‐imidazo[2,1‐a]isoindole‐3‐carboxylates with aryl bromides is reported. This methodology gives ready access to a wide range of methyl 5H‐imidazo[2,1‐a]isoindole‐3‐carboxylates that are monoarylated at their benzylic sites. The C(sp3)−H bond arylation methodology is driven by regioselectivity under weakly basic conditions avoiding remarkably side C(sp2)−H poly‐arylation of the (hetero)aromatic unit. The process was applied to the preparation of novel imidazo[2,1‐a]isoindole‐based neurotransmitter Neuropeptide S antagonist analog.

01 Nov 2023·The Chemical Record

Cover Picture: Photocatalytic and Electrochemical Borylation and Silylation Reactions (Chem. Rec. 11/2023)

Author: Poisson, Thomas ; Biremond, Tony ; Jubault, Philippe ; Riomet, Margaux

01 Nov 2022·Composites Part A: Applied Science and Manufacturing

Meso-structure-based thermomechanical modelling of thermoplastic-based laminates subjected to combined mechanical loading and severe thermal gradients

Author: Barbe, Fabrice ; Vieille, Benoit ; Coppalle, Alexis ; Carpier, Yann

This paper presents a numerical modeling methodol. to investigate the thermo-mechanics of carbon reinforced thermoplastic-based laminates in the situation of mech. loading combined to thermal gradients.It concerns in particular the case of thermal irradiation on one face of the laminate, where temperature varies both from point to point of the laminate and through time, and ranges from the ambient to the temperature of matrix decomposition onset.Temperature is the key variable to determine the phys. state and the properties of each phase of the composite.Particular attention is therefore paid to identifying the resp. material properties according to temperatureThe developed numerical model is based on an explicit representation of the yarn-matrix spatial arrangement within a representative volume element of the considered laminate.From this model the influence of the heterogeneous matrix thermal degradation on the macro-scale thermal dependent properties of the composite is discussed.Such a modeling requires the consideration of a wide range of phenomena (modification of phys. and mech. properties) and a comprehensive set of thermal boundary conditions (heterogeneous distribution of heat flux d. on the sample surface, convection, radiation).The proposed model provides a very good prediction of the laminate's stiffness evolution according to temperature up to the onset of thermal decomposition temperatureIt further enables to analyze the gradual efforts take up between the plies when a constant mech. loading is combined to a heat exposure.

100 Deals associated with INSA Rouen

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100 Translational Medicine associated with INSA Rouen

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Pipeline

Pipeline Snapshot as of 23 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 2 Clinical

1

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