Delving into the Latest Updates on Biomeasure, Inc. with Synapse

Overview

Basic Info

Introduction

Biomeasure, Inc. is a pharmaceutical company based in Milford, MA, and is a subsidiary of Ipsen SA. The company was established by Jacques Pierre Moreau and specializes in the development and production of pharmaceutical preparations.

AbstractAffinities of trimebutine (TMB) and N-desmethyl trimebutine (NDTMB) for mu, delta and kappa opioid receptor subtypes have been examined using specific 3H-ligands and guinea-pig membrane. TMB and NDTMB showed a relative higher affinity for the mu receptor subtype although they were, respectively, 30-and 48-fold less active than morphine. The receptor selectivity index for mu, delta and kappa were 100:12:14ṁ4 for TMB, 100:32:25 for NDTMB and 100:5:5 for morphine. The sodium shift ratio was 14 for TMB, 10 for NDTMB and 37 for morphine. These data show that (unlike morphine, a pure mu agonist) TMB and NDTMB can be classified as weak opioid agonists and confirm that peripheral opioid receptors mediate their gastrointestinal motility effects.

07 Jul 2009·Proceedings of the National Academy of SciencesQ1 · CROSS-FIELD

Requirement of central ghrelin signaling for alcohol reward

Q1 · CROSS-FIELD

Article

Author: Landgren, Sara ; Heilig, Markus ; Jerlhag, Elisabet ; Datta, Rakesh ; Perrissoud, Daniel ; Egecioglu, Emil ; Engel, Jörgen A. ; Dickson, Suzanne L. ; Salomé, Nicolas ; Moechars, Diederik

The stomach-derived hormone ghrelin interacts with key CNS circuits regulating energy balance and body weight. Here we provide evidence that the central ghrelin signaling system is required for alcohol reward. Central ghrelin administration (to brain ventricles or to tegmental areas involved in reward) increased alcohol intake in a 2-bottle (alcohol/water) free choice limited access paradigm in mice. By contrast, central or peripheral administration of ghrelin receptor (GHS-R1A) antagonists suppressed alcohol intake in this model. Alcohol-induced locomotor stimulation, accumbal dopamine release and conditioned place preference were abolished in models of suppressed central ghrelin signaling: GHS-R1A knockout mice and mice treated with 2 different GHS-R1A antagonists. Thus, central ghrelin signaling, via GHS-R1A, not only stimulates the reward system, but is also required for stimulation of that system by alcohol. Our data suggest that central ghrelin signaling constitutes a potential target for treatment of alcohol-related disorders.

01 Apr 2008·Annales d'EndocrinologieQ4 · MEDICINE

New peptide-based therapies for metabolic diseases

Q4 · MEDICINE

Article

Author: Culler, M D

100 Deals associated with Biomeasure, Inc.

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100 Translational Medicine associated with Biomeasure, Inc.

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Pipeline

Pipeline Snapshot as of 26 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

BIM-23244 ( SSTR2 x SSTR5 )	Acromegaly More	Discontinued
BIM-28011 ( GHRH )	Skin Ulcer More	Discontinued
BIM-23268 ( SSTR )	Diabetes Mellitus, Type 2 More	Discontinued