Delving into the Latest Updates on Sosei R&D Ltd. with Synapse

Overview

Tags

Nervous System Diseases

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Nervous System Diseases	2

Top 5 Drug Type	Count

Small molecule drug	2

Top 5 Target	Count

CGRP x CGRP receptor	2

Nefopam is a modestly potent but non-selective inhibitor of serotonin and noradrenaline reuptake (S+NRI).In addition the mol. possesses significant central antihistamine (H1 antagonist) activity.Nefopam (1) suffers from extensive first pass metabolism to an inactive N-demethyl metabolite, lowering bioavailability and limiting efficacy in animal models.The discovery of novel anti-emetic pharmacol. in nefopam (1) has led Arakis to undertake a property driven medicinal chem. program aimed at improving the potency and selectivity of the template while enhancing pharmacokinetics.ARAK0029 (2) is a potent selective serotonin reuptake inhibitor (SSRI), devoid of antihistamine activity.The compound is primarily metabolized by O-demethylation to an -active′ metabolite increasing the pharmacodynamics of the template.A second series based on ARAK0051 (3) are representative of a potent class of S+NRI′s.Strategies to improve pharmacokinetics and eliminate CYP2D6 activity will be presented and exemplified by derivatives from a second wave of medicinal chem.Lead compounds are now devoid of both H1 antagonist activity and the CYP2D6 inhibition present in the parent mol.

100 Deals associated with Sosei R&D Ltd.

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100 Translational Medicine associated with Sosei R&D Ltd.

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Pipeline

Pipeline Snapshot as of 07 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

2

16

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

HTL-0029881 ( CGRP x CGRP receptor )	Migraine Disorders More	Preclinical
HTL0029882 ( CGRP x CGRP receptor )	Migraine Disorders More	Preclinical
SRSC-371	Epilepsy More	Discontinued
SRSS-021 ( 5-HT3 receptor )	Chemotherapy-induced nausea and vomiting More	Discontinued
AD-529 ( NMDA receptor )	Neuralgia More	Discontinued