Delving into the Latest Updates on Suzhou Kebo Ruijun Biosciences Co. Ltd. with Synapse

Overview

Tags

Immune System Diseases

Hemic and Lymphatic Diseases

Neoplasms

Monoclonal antibody

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	1
Immune System Diseases	1
Hemic and Lymphatic Diseases	1

Top 5 Drug Type	Count

Monoclonal antibody	1

Top 5 Target	Count

CD39(Ectonucleoside triphosphate diphosphohydrolase 1)	1

评价JS019单药在晚期恶性实体瘤患者中的安全性和耐受性；确定JS019单药的最大耐受剂量（MTD）或最佳生物效应剂量（OBD）和II期临床研究推荐剂量（RP2D）评价JS019单药在晚期恶性实体瘤患者中的药代动力学（PK）特征评价JS019单药在晚期恶性实体瘤患者中的免疫原性；评价JS019单药在晚期恶性实体瘤患者体内的药效学特征；初步评估JS019单药治疗晚期恶性实体瘤的有效性。

[Translation]

Evaluate the safety and tolerability of JS019 monotherapy in patients with advanced malignant solid tumors; Determine the maximum tolerated dose (MTD) or best biological effect dose (OBD) of JS019 monotherapy and the recommended dose (RP2D) for Phase II clinical studies Evaluate the pharmacokinetic (PK) characteristics of JS019 monotherapy in patients with advanced malignant solid tumors Evaluate the immunogenicity of JS019 monotherapy in patients with advanced malignant solid tumors; Evaluate the pharmacodynamic characteristics of JS019 monotherapy in patients with advanced malignant solid tumors; Preliminary evaluation of the effectiveness of JS019 monotherapy in the treatment of advanced malignant solid tumors.

Start Date09 Sep 2022

Sponsor / Collaborator

Suzhou Kebo Ruijun Biosciences Co. Ltd.

CTR20220434

/ RecruitingPhase 1

重组全人源抗CD39单克隆抗体JS019单药在晚期实体瘤或淋巴瘤患者中的安全性、耐受性、药代动力学特征和初步有效性的I期临床研究

[Translation] A phase I clinical study of the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of JS019, a recombinant fully human anti-CD39 monoclonal antibody, in patients with advanced solid tumors or lymphomas

评价JS019单药在晚期恶性实体瘤/淋巴瘤患者中的安全性和耐受性；确定JS019单药的最大耐受剂量（MTD，如果可能）和II期临床研究推荐剂量（RP2D）评价JS019单药在晚期恶性实体瘤/淋巴瘤患者中的药代动力学（PK）特征；评价JS019单药在晚期恶性实体瘤/淋巴瘤患者中的免疫原性；评价JS019单药在晚期恶性实体瘤/淋巴瘤患者体内的药效学特征；初步评估JS019单药治疗晚期恶性实体瘤/淋巴瘤的有效性探索相关生物标志物与疗效间的相关性

[Translation]

Evaluate the safety and tolerability of JS019 monotherapy in patients with advanced malignant solid tumors/lymphomas; Determine the maximum tolerated dose (MTD, if possible) and recommended dose (RP2D) of JS019 monotherapy for Phase II clinical studies Evaluate the pharmacokinetic (PK) characteristics of JS019 monotherapy in patients with advanced malignant solid tumors/lymphomas; Evaluate the immunogenicity of JS019 monotherapy in patients with advanced malignant solid tumors/lymphomas; Evaluate the pharmacodynamic characteristics of JS019 monotherapy in patients with advanced malignant solid tumors/lymphomas; Preliminary evaluation of the effectiveness of JS019 monotherapy in the treatment of advanced malignant solid tumors/lymphomas Explore the correlation between relevant biomarkers and efficacy

Start Date14 Apr 2022

Sponsor / Collaborator

Suzhou Kebo Ruijun Biosciences Co. Ltd.

NCT05374226

/ Unknown statusPhase 1

A Phase 1 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of Recombinant Fully Human Anti-CD39 Monoclonal Antibody JS019 in Patients With Advanced Solid Tumors or Lymphomas

This is a phase 1 clinical study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of JS019 as monotherapy in patients with advanced malignant solid tumors/lymphomas.
The study includes JS019 monotherapy dose escalation, dose expansion and indication expansion stages to investigate the safety, tolerability, pharmacokinetics and preliminary anti-tumor efficacy of JS019 as monotherapy.

Start Date31 Mar 2022

Sponsor / Collaborator

Suzhou Kebo Ruijun Biosciences Co. Ltd.

100 Clinical Results associated with Suzhou Kebo Ruijun Biosciences Co. Ltd.

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0 Patents (Medical) associated with Suzhou Kebo Ruijun Biosciences Co. Ltd.

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100 Deals associated with Suzhou Kebo Ruijun Biosciences Co. Ltd.

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100 Translational Medicine associated with Suzhou Kebo Ruijun Biosciences Co. Ltd.

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Pipeline

Pipeline Snapshot as of 14 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1 Clinical

1

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