The aim of this review article is to provide the scientific update of the advances coming in the drug delivery system via topical route of administration. The current review focus on the advanced methods and techniques which are available for administration of local therapy to the skin and its parts in form of nanoemulsions liposome aerosols micronidles ethosome, nanoparticles aquasomes adhesives etc. and devices like iontophoresis electroporation magnetophoresis etc. This information can withstand as basis for further development and upgradation existing methods and technologies.