The goal of this observational study is to investigate the incidence, current management practices, and outcomes in pediatric patients with HAC after liver transplantation.
Research question:
What are the overall incidence of HAC and the effectiveness of all treatment strategies for HAC after pediatric LT?
What are the current management practices in the experience of centers, anticoagulant therapy, screening protocol, and assessment criteria for HAC after pediatric LT?
The burden of participation is considered to be minimal, and limited to the questionnaires.

Start Date28 Sep 2023

Sponsor / Collaborator

University Medical Center Groningen

[+21]

CTRI/2023/08/057001 / Not yet recruitingNot ApplicableIIT

Outcome of New Onset Septic Shock in ICU population - ICU

Start Date03 Sep 2023

Sponsor / Collaborator

Max Smart Super Speciality Hospital

CTRI/2023/08/056753 / Not yet recruitingPhase 4IIT

Comparative evaluation of neuromuscular monitoring at the adductor pollicis and trapezius muscle as indicator of favourable intubating conditions - nil

Start Date31 Aug 2023

Sponsor / Collaborator

Max Smart Super Speciality Hospital

100 Clinical Results associated with Max Smart Super Speciality Hospital

0 Patents (Medical) associated with Max Smart Super Speciality Hospital

1,040

Literatures (Medical) associated with Max Smart Super Speciality Hospital

01 Nov 2024·Clinical Nuclear Medicine

A Rare Case of Renal Malakoplakia Incidentally Detected on 18F-FDG PET/CT in a Patient With Concomitant Breast Cancer and Lymphoma

Article

Author: Sharma, Kanchan ; Dougall, Pankaj ; Bal, Jaspriya ; Wakankar, Ritwik

AbstractMalakoplakia is a rare inflammatory disease that most frequently affects the urinary tract. We present the case of a patient who had been receiving treatment for breast cancer, who later on went on to develop diffuse large B-cell lymphoma for which she was started on RCHOP therapy. It was during her treatment that she underwent a whole-body 18F-FDG PET/CT for response evaluation and was incidentally diagnosed to have bilateral renal malakoplakia, which resolved after a prolonged course of antibiotic therapy.

01 Nov 2024·Molecular Neurobiology

Gene Expression Analysis in T2DM and Its Associated Microvascular Diabetic Complications: Focus on Risk Factor and RAAS Pathway

Article

Author: Singh, Tashvinder ; Jena, Laxmipriya ; Munshi, Anjana ; Kaur, Prabhsimran ; Kotru, Sushil ; Sharma, Kangan

Prolonged hyperglycemic conditions in type 2 diabetes mellitus (T2DM) cause pathological and functional damage to many organs and tissues, including the kidneys, retina, skin, and neuronal tissues, resulting in the development of microvascular diabetic complications. The altered renin angiotensin aldosterone system (RAAS) pathway has been reported to play an important role in the development of insulin resistance in T2DM and associated complications. The current study was carried out to evaluate the association of risk factors and altered expression of RAAS genes in T2DM patients without complications and T2DM patients with complications (retinopathy, nephropathy, and neuropathy). Four hundred and twenty subjects including 140 healthy controls, 140 T2DM patients with diabetic complications, and 140 T2DM patients without diabetic complications were included in the study. Risk factors associated with the development of T2DM and diabetic complications were evaluated. Further, expression analysis of RAAS genes (AGT, ACE, ACE2, and AGT1R) was carried out using qRTPCR in healthy controls, T2DM patients with complications, and T2DM patients without complications. Various risk factors like urban background, higher BMI, alcoholism, smoking, and family history of diabetes among others were found to be associated with the development of T2DM as well as diabetic complications. The expression level of AGT, ACE, and AGT1R was found to be upregulated whereas ACE2 was found to be downregulated in T2DM patients with complications and T2DM patients without complications as compared to controls. Altered expression of the studied genes of RAAS pathway is associated with the development of microvascular diabetic complications.

01 Oct 2024·Lupus

The (reverse) paradox of lupus anticoagulant: A case report

Article

Author: Rath, Prasan Deep ; Kalyani, Hiren ; Pandey, Swetal ; Goyal, Mayank ; Banavathu, Tejaswee

Introduction Systemic Lupus Erythematosus (SLE) is often associated with antiphospholipid syndrome (APS), which manifests as recurrent thrombotic events or obstetric complications in presence of antiphospholipid antibodies. Hereby we present a case of a child who presented with low grade fever, superficial thrombophlebitis with mucosal bleeding and was diagnosed as Lupus Anticoagulant Hypoprothrombonemia Syndrome (LAHS). Case A 7-year-old girl was hositalized with complaints of fever and spontaneous bleeding from gums and epistaxis. On examination, she had multiple small tender nodular lesions with greenish hue of overlying skin suggesting superficial thrombophlebitis and mild non-tender hepatosplenomegaly. Her coagulogram revealed normal platelet counts and deranged PT and APTT. ESR and CRP were raised. Serology for viral infections, blood and urine cultures were negative. Patient had persistent coagulopathy, mucosal bleeding and low-grade fever despite supportive treatment. She was tested for anti-nuclear antibodies (ANA) in view of suspicion of autoimmune process. ANA was positive in high titer with speckled pattern on indirect immunofluorescence. Mixing studies showed correction of PT and non-correction of APTT. PT based factors were normal except for prothrombin (FII) which was low and remained low despite dilution. APTT based factors (FVIII and FIX) were low but corrected on dilution. This was suggestive of prothrombin deficiency and a presence of a nonspecific inhibitor of APTT pathway (likely lupus anticoagulant). Presence of antiprothrombin antibodies established the diagnosis of LAHS. ENA profile was positive for SmD1, Ro60 and Ku. Complement levels were low. Direct Coomb’s test was positive but there was no evidence of hemolysis. Lupus anticoagulant by DRVVT and anti-cardiolipin antibodies by ELISA were positive. Patient was diagnosed as Systemic Lupus Erythematosus with Lupus Anticoagulant Hypoprothrombinemia Syndrome. She was treated with IV methylprednisolone. Patient showed significant improvement in form of resolution of fever, mucosal bleeding, correction of deranged INR and reversal of hypocomplementemia. She was discharged on hydroxychloroquine, mycophenolate mofetil and tapering doses of prednisolone. On follow up, child was doing well and her prothrombin time and complement levels had normalized. Low dose aspirin was aspirin was added for thromboprophylaxis.

100 Deals associated with Max Smart Super Speciality Hospital

100 Translational Medicine associated with Max Smart Super Speciality Hospital

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