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Cardiovascular Diseases

Peptide drug conjugates

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Peptide drug conjugates	1

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ACE(Angiotensin-converting enzyme)	1

Three novel self-assembled Ph pyrazole cationic surfactant derivatives, coded as SA-6, SA-12, and SA-18, were synthesized, structure confirmed, and examined as eco-friendly corrosion inhibitors for Cu in 1 M HNO₃ electrolyte using open circuit potential (OCP), potentiodynamic polarization (PDP), and electrochem. impedance spectroscopy (EIS) measurements.The efficacy of these surfactants was pointedly influenced by dosage (5 x 10^-5 M - 1 x 10^-3 M), attaining a maximum of 90.9 %, 92.9 %, and 94.5 % for SA-6, SA-12, and SA-18, resp., at 1 x 10^-3 M.The fact that the highest shift in corrosion potential (E_corr) is so minor suggests that the compounds under investigation are inhibitors of the mixed type (anodic/cathodic).The high value of K_ads and the neg. ΔGo_ads value (-35.0, -35.8, and -36.8 kJ mol^-1) suggests that the SA-6, SA-12, and SA-18 inhibitors have a strong and spontaneous tendency to adsorbed onto the Cu substrate.The development of the self-assembled surfactant defensive film on the Cu substrate was morphol. verified by at. force microscopy (AFM).The studied self-assembled surfactants adsorbed phys. and chem. according to Langmuir isotherm model.Quant. structure-activity relationship (QSAR) was used to construct the prediction model for SA-6, SA-12, and SA-18′s anti-corrosion properties, while d. functional theory (DFT) calculations were used to determine the chem. descriptors linked to the frontier MOs (FMOs).It was shown that the results of the computational and electrochem. experiments were highly consistent.

18 Sep 2024·Materials Research Innovations

Auto-combustion synthesis of lanthanum-doped TiO ₂ nanostructures for efficient photocatalytic degradation of crystal violet dye

Author: Meselhy, Gharieb M. ; Nassar, Mostafa Y. ; Nassar, Ibrahim M. ; Seda, Sabry H.

16 Sep 2024·Critical Reviews in Environmental Science and Technology

Modification strategies of BiOI-based visible-light photocatalysts and their efficacy on decomposition of tetracycline antibiotics in water

Author: Kim, Ki-Hyun ; Younis, Sherif A. ; Ahmadi, Younes ; Sun, Yang

Photocatalysis is regarded as a potent alternative to conventional treatment methods with low removal efficiency (e.g., activated sludge process) against refractory/recalcitrant antibiotics in wastewater.Here, the potential utility of bismuth oxyiodide (BiOI)-based materials has been evaluated as visible-light-driven photocatalysts (bandgap energy < 2.0 eV) with unique optical structure for the enhanced treatment of tetracyclines (TCs) as a representative antibiotic product.The effects of key modification strategies (e.g., elemental doping and heterojunction formation) on the photocatalytic activity of BiOI-based photocatalysts are assessed against TCs in terms of the key performance metrics such as quantum efficiency (QE) and space-time yield (STY).This review also highlights the challenges and promising opportunities for the photocatalytic application of BiO-based materials against TCs in real effluents.Accordingly, zinc-doped BiOI is recognized to have the maximum efficiency with QE of 2.95 x 10^-5 mols. photon^-1 and STY of 2.95 x 10^-7 mols. photon^-1 mg^-1.This review is expected to help deepen the exploration path to the construction of efficient BiOI-based systems based on their performance evaluation along with the discussions on their perspectives.

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Pipeline

Pipeline Snapshot as of 11 Oct 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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