Suzhou Hightechbio Biotechnology Co. Ltd.

1. Dose confirmation phase: evaluate the safety and tolerability of three dosing regimens of HT001 in patients with advanced esophageal cancer and determine the subsequent recommended dosing regimen; 2. Cohort expansion phase: evaluate the efficacy of HT001 in patients with advanced solid tumors;

1. To evaluate the safety and tolerability of docetaxel polymer micelles for injection in patients with advanced malignant solid tumors. 2. To compare the PK similarity between docetaxel polymer micelles for injection and taxotere injection. 3. To obtain the pharmacokinetic parameters of docetaxel polymer micelles for injection in patients with advanced malignant solid tumors. 4. To compare the safety of docetaxel polymer micelles for injection and taxotere injection. 5. To preliminarily observe the anti-tumor efficacy of docetaxel polymer micelles for injection.