Last update 01 Nov 2024

Sher-I-Kashmir Institute of Medical Sciences

Education

skimsmc.edu.in

Education

skimsmc.edu.in

Last update 01 Nov 2024

Overview

Pipeline

Deal

Translational Medicine

Overview

Clinical Trials associated with Sher-I-Kashmir Institute of Medical Sciences

CTRI/2024/09/073486 / Not yet recruitingNot ApplicableIIT

Effects of nimodipine on intra-arterial diameter and Global circulation times in patients of sub arachnoid hemorrhage - An observational study - NIL

Start Date01 Oct 2024

Sponsor / Collaborator

Sher-I-Kashmir Institute of Medical Sciences

CTRI/2022/05/042369 / Not yet recruitingNot ApplicableIIT

Validation of Low Anterior Resection Syndrome (LARS) Score in Kashmir valley - LARS

Start Date05 May 2022

Sponsor / Collaborator

Sher-I-Kashmir Institute of Medical Sciences

CTRI/2021/04/032746 / CompletedPhase 3IIT

Role of Autologous Blood Clot Seal in Preventing Pneumothorax in CT-guided Lung Biopsy.

Start Date12 Apr 2021

Sponsor / Collaborator

Sher-I-Kashmir Institute of Medical Sciences

100 Clinical Results associated with Sher-I-Kashmir Institute of Medical Sciences

0 Patents (Medical) associated with Sher-I-Kashmir Institute of Medical Sciences

3,078

Literatures (Medical) associated with Sher-I-Kashmir Institute of Medical Sciences

01 Dec 2024·Molecular Biology Reports

Recent advances in the therapeutic applications of selenium nanoparticles

Review

Author: Ahemad, Nafees ; Ansari, Jeba Ajgar ; Manzoor, Muntaha ; Anwar, Sirajudheen ; Malik, Jonaid Ahmad ; Ahmed, Sakeel

AbstractSelenium nanoparticles (SeNPs) are an appealing carrier for the targeted delivery. The selenium nanoparticles are gaining global attention because of the potential therapeutic applications in several diseases e.g., rheumatoid arthritis (RA), inflammatory bowel disease (IBD), asthma, liver, and various autoimmune disorders like psoriasis, cancer, diabetes, and a variety of infectious diseases. Despite the fact still there is no recent literature that summarises the therapeutic applications of SeNPs. There are some challenges that need to be addressed like finding targets for SeNPs in various diseases, and the various functionalization techniques utilized to increase SeNP’s stability while facilitating wide drug-loaded SeNP distribution to tumor areas and preventing off-target impacts need to focus on understanding more about the therapeutic aspects for better understanding the science behind it. Keeping that in mind we have focused on this gap and try to summarize all recent key targeted therapies for SeNPs in cancer treatment and the numerous functionalization strategies. We have also focused on recent advancements in SeNP functionalization methodologies and mechanisms for biomedical applications, particularly in anticancer, anti-inflammatory, and anti-infection therapeutics. Based on our observation we found that SeNPs could potentially be useful in suppressing viral epidemics, like the ongoing COVID-19 pandemic, in complement to their antibacterial and antiparasitic uses. SeNPs are significant nanoplatforms with numerous desirable properties for clinical translation.Graphical Abstract

01 Sep 2024·Journal of Gastrointestinal Cancer

“GLI1 Subcellular Localization and Overexpression as Prognostic Factors for Disease-Free Survival in Colorectal Carcinoma”

Article

Author: Haq, Rather Izhar Ul ; Akhtar, Kulsum ; Mudassar, Syed ; Parveiz, Ishrat ; Wani, Rauf A ; Rather, Tahseen Bilal ; Rashid, Gowhar ; Besina, Syed

PURPOSEGlioma-associated oncogene homolog-1 (GLI1) is amplified in human glioblastoma, and there is growing evidence suggesting its significant role in tumor development and metastasis. Our aim was to investigate the role of the GLI-1 gene in the progression of colorectal cancer (CRC) and its correlation with various clinicopathological features. Additionally, we examined the impact of the GLI-1 gene and other factors on the prognosis of CRC.METHODSWe analyzed a total of 98 confirmed CRC cases and adjacent normal tissue controls. Patients suspected of having colon cancer underwent a colonoscopy and targeted biopsy, while those with rectal cancer underwent CT scans and MRI. GLI1 expression was detected using real-time PCR assay, Western blotting, and immunohistochemistry.RESULTSThe GLI1 gene was observed to be overexpressed in tumor tissues at both the protein and mRNA levels (p < 0.05). In addition, GLI1 overexpression was significantly associated with various factors such as tumor invasion (T3/T4), presence of lymph nodes, lymph node metastasis (LNM), stage (III/IV), tumor site (colon), tumor size (≥ 3 cm), localization (nucleocytoplasmic), strong staining intensity and recurrence (p < 0.05). The results of survival analysis showed that the patients with overexpression of GLI1 had a significantly lower DFS rate which was 21 months compared to those with normal expression who had 31 months (p < 0.05). Moreover, individuals with early onset disease (15 months) were more likely to have cytoplasmic localization of the GLI1 gene as opposed to nucleo-cytoplasmic localization of GLI1 which presented late-onset disease( 23 months) (p < 0.05). Finally, Stage and PNI (p < 0.05) were found to independently affect outcomes of CRC according to Cox regression analysis.CONCLUSIONHigh expression of GLI-1 in CRC is associated with adverse pathology and poor prognosis for patients. The correlation between cytoplasmic localization of GLI-1 and reduced disease-free survival holds potential for guiding prognosis and treatment. Further research is needed to develop strategies targeting GLI-1 for improved outcomes.

01 Sep 2024·Current Pharmaceutical Design

Green Synthesis of Silver Nanoparticles and their Potential Applications in Mitigating Cancer

Review

Author: din Wani, Shahid ud ; Pottoo, Faheem Hyder ; Hussain, Md. Sadique ; Mir, Prince Ahad ; Mohi-ud-din, Roohi ; Mir, Reyaz Hassan ; Maqbool, Mudasir

:In recent years, the field of nanotechnology has brought about significant advancements that have transformed the landscape of disease diagnosis, prevention, and treatment, particularly in the realm of medical science. Among the various approaches to nanoparticle synthesis, the green synthesis method has garnered increasing attention. Silver nanoparticles (AgNPs) have emerged as particularly noteworthy nanomaterials within the spectrum of metallic nanoparticles employed for biomedical applications. AgNPs possess several key attributes that make them highly valuable in the biomedical field. They are biocompatible, cost-effective, and environmentally friendly, rendering them suitable for various bioengineering and biomedical applications. Notably, AgNPs have found a prominent role in the domain of cancer diagnosis. Research investigations have provided evidence of AgNPs' anticancer activity, which involves mechanisms such as DNA damage, cell cycle arrest, induction of apoptosis, and the regulation of specific cytokine genes. The synthesis of AgNPs primarily involves the reduction of silver ions by reducing agents. Interestingly, natural products and living organisms have proven to be effective sources for the generation of precursor materials used in AgNP synthesis. This comprehensive review aims to summarize the key aspects of AgNPs, including their characterization, properties, and recent advancements in the field of biogenic AgNP synthesis. Furthermore, the review highlights the potential applications of these nanoparticles in combating cancer.

100 Deals associated with Sher-I-Kashmir Institute of Medical Sciences

100 Translational Medicine associated with Sher-I-Kashmir Institute of Medical Sciences

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Sher-I-Kashmir Institute of Medical Sciences

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