Université Fédérale Toulouse Midi-Pyrénées

JERSEY CITY, N.J., Aug. 28, 2023 /PRNewswire/ -- Mitsubishi Tanabe Pharma America, Inc. (MTPA) today announced that four presentations in Parkinson's disease (PD) will be shared at the International Congress of Parkinson's Disease and Movement Disorder Society (MDS), being held in Copenhagen, Denmark, August 27-31. "We're eager to share our latest data for investigational ND0612 in Parkinson's disease, including the results from the pivotal Phase 3 BouNDless study following positive topline data from earlier this year, and findings from a responder-analysis of the Phase 2b BeyoND long-term safety study," said Gustavo A. Suarez Zambrano, M.D., Vice President of Medical Affairs at MTPA. "Our presence at MDS, where we have the opportunity to continue sharing our progress with the scientific community, reflects our commitment and ongoing efforts to find ways to tackle debilitating conditions like Parkinson's disease." All posters will be showcased in the Poster and Exhibit Hall (Hall C). Specific timing is noted below. Presentation Details: Presentations include results from the ongoing pivotal Phase 3 multi-center, randomized, double-blind double-dummy (DBDD) BouNDless study evaluating the efficacy, safety and tolerability of investigational ND0612 in people with PD experiencing motor fluctuations, in addition to findings of a responder-analysis from the Phase 2b BeyoND long-term safety study assessing the efficacy of ND0612 in reducing OFF time in people with PD with motor fluctuations. Results from the BouNDless study, which follow positive topline data reported earlier this year, will be presented as both a poster and part of an Oral Platform Presentation at the meeting. Additional presentations will highlight three-year safety and efficacy outcomes from the BeyoND long-term safety study, and the development of a Motor Fluctuations Patient Journey Map for people with PD to describe the holistic patient experience from pre-diagnosis through hospice care. Continuous subcutaneous levodopa/carbidopa infusion with ND0612 for patients with Parkinson's disease and motor fluctuations: Results from the Phase 3 randomized, active-controlled BouNDless study Abstract #11: 1:00 p.m. – 3:00 p.m. CEST, August 28 Oral Platform Presentation Group 5: Clinical Trials (1:45 p.m. - 2:45 p.m. CEST, August 29; Olivier Rascol M.D., Ph.D.; University of Toulouse) Reductions in OFF time with ND0612 for patients with Parkinson's disease experiencing motor fluctuations: Responder-analysis from an open-label Phase 2 study Abstract #46: 1:00 p.m. – 3:00 p.m. CEST, August 28 Continuous subcutaneous levodopa/carbidopa infusion with ND0612 for PD: 3-year data from the open-label BeyoND study Abstract #108: 1:00 p.m. – 3:00 p.m. CEST, August 28 Motor Fluctuations Patient Journey: Development of a patient journey map for people living with PD Abstract #1302: 1:00 p.m. – 3:00 p.m. CEST, August 29 This press release is intended for U.S. audiences only. About ND0612 ND0612 is an investigative drug-device combination therapy – a 24 hours/day, continuous subcutaneous infusion of liquid levodopa/carbidopa (LD/CD) for people with Parkinson's disease (PD) experiencing motor fluctuations. Development of investigational ND0612 is being led by NeuroDerm, Ltd., a wholly-owned subsidiary of Mitsubishi Tanabe Pharma Corporation (MTPC). If regulatory approval for ND0612 is obtained, Mitsubishi Tanabe Pharma America, Inc. (MTPA), intends to commercialize the therapy in the U.S. About Mitsubishi Tanabe Pharma America, Inc. Based in Jersey City, N.J., Mitsubishi Tanabe Pharma America, Inc. (MTPA) is a wholly-owned subsidiary of Mitsubishi Tanabe Pharma Corporation (MTPC). It was established by MTPC to develop and advance our pipeline as well as commercialize approved pharmaceutical products in North America. For more information, please visit or follow us on X (formally, Twitter), Facebook and LinkedIn. About Mitsubishi Tanabe Pharma Corporation Mitsubishi Tanabe Pharma Corporation (MTPC), the pharma arm of Mitsubishi Chemical Group (MCG), is one of the oldest pharmaceutical companies in the world, founded in 1678. MTPC is headquartered in Doshomachi, Osaka, the birthplace of Japan's pharmaceutical industry. MCG has positioned health care as its strategic focus in its management policy, "Forging the future". MTPC sets the MISSION of "Creating hope for all facing illness". To that end, MTPC is working on the disease areas of central nervous system, immuno-inflammation, diabetes and kidney, and cancer. MTPC is focusing on "precision medicine" to provide drugs with high treatment satisfaction and additionally working to develop "around the pill solutions" to address specific patient concerns based on therapeutic medicine, including prevention of diseases, pre-symptomatic disease care, prevention of aggravation and prognosis. For more information, go to . About NeuroDerm, Ltd. NeuroDerm, Ltd. is a wholly-owned subsidiary of Mitsubishi Tanabe Pharma Corporation (MTPC), based in Israel, inspired to reduce disease burden and improve the quality of life of patients and their families through innovative drug-device combination therapies and technologies. NeuroDerm is an integrated pharmaceutical and medical technology company developing central nervous system (CNS) product candidates. For additional information, please visit NeuroDerm's website at  or follow the Company on LinkedIn. Media inquiries: [email protected] SOURCE Mitsubishi Tanabe Pharma America, Inc.

Tropical forest birds, which tend to have wings that are short and round relative to their body length and shape, are more sensitive to habitat fragmentation than the long-, slender-winged species common in temperate forests. Tropical forest birds, which tend to have wings that are short and round relative to their body length and shape, are more sensitive to habitat fragmentation than the long-, slender-winged species common in temperate forests, according to an international collaboration that included scientists from Oregon State University. OSU's Matt Betts and Christopher Wolf teamed with 14 other authors to analyze the wings of more than 1,000 species worldwide in a study led by Thomas Weeks of Imperial College London and published in Nature Ecology and Evolution. The research builds on a 2019 study that was led by Betts and Wolf and published in Science. That paper had shown that the nearer a forest species lives to the equator, where animals evolved in environments that weren't subject to large-scale habitat-altering events like fires and storms, the less well equipped the species is to adapt to current human-caused forest fragmentation. The wing study provides solid evidence for the idea that forest birds in the lower latitudes -- the bare-faced ibis, the blue and gold macaw, the green honeycreeper, the Malaysian rail babbler and many other colorful, and colorfully named, species -- aren't good at relocating when their habitat gets broken up because they weren't required to evolve in ways that would make it easy to get to new areas, Betts said. "The new paper shows a strong latitudinal gradient in birds' ability to disperse -- i.e., move around to find a new place to live," said Betts, a professor of landscape ecology in the OSU College of Forestry. "Birds toward the poles tend to be better movers, with longer, narrower wings that are better suited to long-distance flight." Previously, the reason behind tropical birds' comparative lack of dispersal skills had not been well understood, and there had also been some question as to whether a forest species' ability to move around was all that important in terms of dealing with habitat fragmentation, Wolf said. "It had been argued that species that don't move much maybe tend to stay put just because they don't care about losing pieces of their habitat or seeing it fragmented," said Wolf, a postdoctoral researcher in the College of Forestry. "But we used a massive dataset that encompassed more than 1,000 birds globally to test whether birds with shorter, stubbier wings are more likely to be fragmentation sensitive, and whether this alone explains the latitudinal gradient we observed. In the end, there was strong support for the idea that birds that are good dispersers are less fragmentation sensitive." Examples of temperate forest birds more built for dispersal include woodpeckers, robins, jays, cardinals, owls, turkeys, hawks and eagles. The Natural Environment Research Council, the UKRI Global Challenges Research Fund and the Natural Environment Research Council supported this research. Also contributing to the study were scientists from Newcastle University; the University of Toulouse; Lancaster University; the Foundation for Ecodevelopment and Conservation; the Global Protect Oceans, Lands and Waters Program; the Nature Conservancy; the Swiss Ornithological Institute; Yale University; the University of Pretoria; the Centre for Conservation of Atlantic Forest Birds; the University of Queensland; and California State University, Los Angeles.

ere are some scientific findings worthy of a toast: Researchers have explained why bubbles in Champagne fizz up in a straight line while bubbles in other carbonated drinks, like beer or soda, don’t. Here are some scientific findings worthy of a toast: Researchers from Brown University and the University of Toulouse in France have explained why bubbles in Champagne fizz up in a straight line while bubbles in other carbonated drinks, like beer or soda, don't. The findings, described in a new Physical Review Fluids study, are based on a series of numerical and physical experiments, including, of course, pouring out glasses of Champagne, beer, sparkling water and sparkling wine. The results not only explain what gives Champagne its line of bubbles but may hold important implications for understanding bubbly flows in the field of fluid mechanics. "This is the type of research that I've been working out for years," said Brown engineering professor Roberto Zenit, who was one of the paper's authors. "Most people have never seen an ocean seep or an aeration tank but most of them have had a soda, a beer or a glass of Champagne. By talking about Champagne and beer, our master plan is to make people understand that fluid mechanics is important in their daily lives." The team's goal was to investigate the stability of bubble chains in carbonated drinks. Part of the signature experience of enjoying these beverages is the tiny or large bubbles that form when the drink is poured, creating a visible chain of bubbles and fizz. Depending on the drink and its ingredients, the fluid mechanics involved are all different. When it comes to Champagne and sparkling wine, for instance, the gas bubbles that continuously appear rise rapidly to the top in a single- and keep doing so for some time. This is known as a stable bubble chain. With other carbonated drinks, like beer, many bubbles veer off to the side, making it look like multiple bubbles are coming up at once. This means the bubble chain isn't stable. The researchers set out to explore the mechanics of what makes bubble chains stable and if they could recreate them, making unstable chains as stable as they are in Champagne or prosecco. The results of their experiments indicate that the stable bubble chains in Champagne and other sparkling wines occur due to ingredients that act as soap-like compounds called surfactants. These surfactant-like molecules help reduce the tensions between the liquid and the gas bubbles, making for a smooth rise to the top. "The theory is that in Champagne these contaminants that act as surfactants are the good stuff," said Zenit, senior author on the paper. "These protein molecules that give flavor and uniqueness to the liquid are what makes the bubbles chains they produce stable." The experiments also showed the stability of bubbles is impacted by the size of the bubbles themselves. They found that the chains with large bubbles have a wake similar to that of bubbles with contaminants, leading to a smooth rise and stable chains. In beverages, however, bubbles are always small. It makes surfactants the key ingredient to producing straight and stable chains. Beer, for example, also contains surfactant-like molecules but, depending on the type of beer, the bubbles can rise in straight chains or not. In contrast, bubbles in carbonated water are always unstable since there are no contaminants helping the bubbles move smoothly through the wake flows left behind by the other bubbles in the chain. "This wake, this velocity disturbance, causes the bubbles to be knocked out," Zenit said. "Instead of having one line, the bubbles end up going up in more of a cone." The results in the new study go well beyond understanding the science that goes into celebratory toasts, the researchers said. The findings provide a general framework in fluid mechanics for understanding the formation of clusters in bubbly flows, which have economic and societal value. Technologies that use bubble-induced mixing, like aeration tanks at water treatment facilities, for instance, would benefit greatly from researchers having a clearer understanding of how bubbles cluster, their origins and how to predict their appearance. In nature, understanding these flows may help better explain ocean seeps in which methane and carbon dioxide emerges from the bottom of the ocean. The experiments the research team ran were relatively straightforward -- and some could even be run in any local pub. To observe the bubble chains, the researchers poured glasses of carbonated beverages including Pellegrino sparkling water, Tecate beer, Charles de Cazanove champagne and a Spanish-style brut. To study the bubble chains and what goes into making them stable, they filled a small rectangular plexiglass container with liquid and inserted a needle at the bottom so they could pump in gas to create different kinds of bubble chains. The researchers then gradually added surfactants or increased bubble size. They found that when they made the bubbles larger, they could make unstable bubble chains become stable, even without surfactants. When they kept a fixed bubble size and only added surfactants, they found they could also go from unstable chains to stable ones. The two experiments indicate that there are two distinct possibilities to stabilize a bubble chain: adding surfactants and making bubbles bigger, the researchers explain in the paper. The researchers performed numerical simulations on a computer to explain some of the questions they couldn't explain through the physical experiments, such as calculating how much of the surfactants go into the gas bubbles, the weight of the bubbles and their precise velocity. They plan to keep looking into the mechanics of stable bubble chains in an effort to apply them to different aspects of fluid mechanics, especially in bubbly flows. "We're interested in how these bubbles move and their relationship to industrial applications and in nature," Zenit said.