Full-Life Technologies

GEMBLOUX, Belgium, March 25, 2024 /PRNewswire/ -- Full-Life Technologies ("Full-Life"), today announced the recent achievement of its subsidiary "Full-Life Technology Europe" has obtained a Nuclear Permit for a class IIA facility from the Belgium Federal Agency for Nuclear Control ("FANC"), authorizing the construction and operation of this pivotal facility for producing therapeutic radioisotopes. "The Nuclear Permit is a significant regulatory milestone towards the construction of our radioisotope facility, which is an integral part of Full-Life's strategy to build a fully-integrated radiopharmaceutical company," said Philippe van Put, General Manager of Full-Life Technology Europe. "Actinium-225 ("Ac-225") has emerged as a highly promising, alpha-emitter isotope for use in radiotherapeutics to treat cancer, but demand has outstripped supply. The facility, when completed, will provide this radioisotope to support pre-clinical and clinical studies of our internal pipeline candidates but also for the commercialization of Ac-225 radiolabelled compounds to contribute towards addressing the urgent global demand for Ac-225 radiopharmaceuticals." The permit, for a class IIA facility, reflects result of a comprehensive and effective collaboration among diverse stakeholders, including authorities and control organism. Central to this collaborative effort has been the preparation and submission of a detailed safety report to FANC on the future facility. This report is a critical component of the authorization process, as it must demonstrate that all nuclear safety aspects, including installation, processes, and organizational structure, have been meticulously evaluated and meet stringent safety and regulatory standards. "Obtaining this Nuclear Permit affirms our adherence to the highest nuclear safety standards for our upcoming facility," said Mr. van Put. "Our comprehensive safety measures, forward-thinking production approaches, and reliable logistics systems underscore our dedication to elevating patient care and radiotherapeutic research." The 4,000 square meter, state-of-the-art facility, which will sit on 17,000 square meters of land, will serve as Full-Life's production hub. About Full-Life Technologies Full-Life Technologies Limited ("Full-Life") is a fully integrated global radiotherapeutics company with operations in Belgium, Germany, and China. We seek to own the entire value chain for radiopharmaceutical research & development, production & commercialization in order to deliver clinical impact for patients. The Company plans to attack core issues affecting radiopharmaceuticals today through innovative research that targets the treatments of tomorrow. We are comprised of a team of fast-moving entrepreneurs and scientists with a demonstrated track record in the life sciences, as well as radioisotope research and clinical development. Website: SOURCE Full-Life Technologies

SHANGHAI and GEMBLOUX, Belgium and HEIDELBERG, Germany, Jan. 3, 2024 /PRNewswire/ -- Full-Life Technologies ("Full-Life"), a fully integrated global radiotherapeutics company, today announced the completion of $63.3 million financing, comprised of $47.3 million in Series B equity financing and $16 million in loan facilities. The financing will advance development of the Company's radiopharmaceutical pipeline and manufacturing capabilities, as well as optimize its proprietary discovery platform, UniRDCTM. With completion of such financing, Full-Life has secured more than $110 million funding since its inception in August 2021, including equity financing, loan facilities, and government subsidies. The $47.3 million Series B equity financing was co-led by Prosperity7 Ventures and an undisclosed healthcare specialist investor, along with new investors Sky9 Capital, Summer Capital, and GuanghuaWutong Fund, as well as existing shareholders Chengwei Capital, HongShan, and Junson Capital. The $16 million loan facilities, secured in conjunction with the Series B equity financing, provide Full-Life with a flexible financing solution for the Company's pipeline development and construction of the radiopharmaceutical manufacturing plant in Belgium. "Cancer remains a formidable global challenge, causing immense suffering and loss," said Aysar Tayeb, Executive Managing Director of Prosperity7 Ventures. "Full-Life is dedicated to addressing this issue within the field of Radionuclide Drug Conjugates (RDC) by leveraging its exceptional vector and linker design capabilities, as well as its expertise in radionuclides. Through its UniRDCTM platform, Full-Life has the potential to extend its therapeutic indications to a wider range of cancers. We eagerly anticipate the future advancements of Full-Life, as it strives to deliver differentiated and superior solutions that will significantly improve the outcomes and quality of life for cancer patients." "The financing reflects strong support from our new and existing investors of our strategy and faith in the significant progress we have made in just over two years to build a fully integrated radiopharmaceutical company," said Julie Wu, Chief Financial Officer of Full-Life. "The funding will support our evolution into a clinical-stage company, the advancement of our pipeline programs, and the construction of a Good Manufacturing Practices (GMP) manufacturing facility." Since completion of its Series A equity financing in 2022, Full-Life has achieved multiple significant milestones, including but not limited to: Advancing the Company's lead drug candidate, 225Ac-FL-020, towards Phase I clinical trials in metastatic castration-resistant prostate cancer (mCRPC) patients. Clinical trials are planned to start in both Europe and the U.S. in early 2024. Full-Life's PSMA-targeting vector, FL-020, is specifically designed to deliver the highly potent alpha-emitter, Actinium-225. Assembling a strong pre-clinical portfolio including both first-in-class and best-in-class programs as well as development of the novel UniRDCTM discovery platform. UniRDCTM is a proprietary platform established to streamline the discovery process of RDC. Acquiring a 17,000 square meter of land in the Walloon region of Belgium, obtaining the required construction permit, and beginning construction of a 4,000 square meter state-of-the-art GMP-level radiopharmaceutical production facility. The facility is designed to advance Full-Life's end-to-end solution and manufacture a broad spectrum of radiopharmaceuticals. About 225Ac-FL-020 225Ac-FL-020 is a novel, next-generation PSMA radioligand candidate currently being developed for the treatment of mCRPC. Its targeting vector, FL-020, was discovered using Full-Life's proprietary Clear-XTM linker technology, which enables significant improvement of drug uptake at the tumor while maintaining fast systemic clearance. In pre-clinical models, 225Ac-FL-020 has demonstrated promising anti-tumor activity. About UniRDCTM UniRDCTM is a proprietary discovery platform, which rationalizes and accelerates the discovery process of RDC drug candidates. UniRDCTM enables a short discovery timeline of 18 months or less from a target to an RDC development candidate with human biodistribution data, which has been repeatedly validated internally. UniRDCTM covers a range of modalities including small molecule, cyclic peptide, and nanobody. It is centered on a rich set of proprietary synthetic chemistry and protein engineering tool kits, including Clear-X™ linker technology and Res-X™ modification methods. Such tool kits have been proven to be essential to rapidly turn an affinity matured binder to a development candidate with a therapeutically optimal biodistribution profile. Details of the platform can be found at: About Full-Life Technologies Full-Life Technologies Limited ("Full-Life") is a fully integrated global radiotherapeutics company with operations in Belgium, Germany, and China. We seek to own the entire value chain for radiopharmaceutical research & development, production & commercialization in order to deliver clinical impact for patients. The Company plans to attack core issues affecting radiopharmaceuticals today through innovative research that targets the treatments of tomorrow. We are comprised of a team of fast-moving entrepreneurs and scientists with a demonstrated track record in the life sciences, as well as radioisotope research and clinical development. About Prosperity7 Prosperity7 Ventures (P7) is the diversified growth fund of Aramco Ventures, a subsidiary of Aramco, the world's leading integrated energy and chemicals company. The fund's name derives from "Prosperity Well', the 7th oil well drilled in Saudi Arabia and the first to strike oil. Taking forward this pioneering history, P7 invests globally with a long-term view in breakthrough technologies and transformational business models that will bring prosperity and positive impact on a vast scale. Follow us: Website: SOURCE Full-Life Technologies

JERSEY CITY, N.J. and SHANGHAI, Dec. 2, 2022 /PRNewswire/ -- Focus-X Therapeutics (referred to here as "Focus-X"), a nuclide drug company that was invested in and incubated by Viva Biotech, successfully reached an acquisition agreement with Full-Life Technologies Co., Ltd. (referred to here as "Full-Life"). Under the terms of the acquisition, Full-Life will acquire Focus-X for US$245 million, including an upfront payment, potential development, regulatory, and sales-based milestone fees, and royalties on commercial sales. The acquisition is expected to close in the first quarter of 2023. When finished, this will be another pre-clinical acquisition of one of Viva's portfolio companies, after Dogma and Totient, which once again verifies the capabilities of project discovery and the professional post-investment support of Viva's investment team. Focus-X develops targeted radiopharmaceuticals to treat cancer based on its proprietary peptide engineering technology. They completed their angel round in the third quarter of 2020, which was led by Viva. In addition to financial support, Viva also provided Focus-X with comprehensive incubation services to help it realize the transformation from "concept to product." Dr. Zhixiong Ye, CSO of Viva, stated, "Since investing in and incubating Focus-X in July 2020, Viva has worked closely with Focus-X on the screening and synthesis of peptides, which is an enriching experience for our team. Highly selective peptides can tackle the pain point of peptide-conjugated nuclide drugs - the toxicity caused by 'healthy tissue distribution'. Viva provides efficient and high-quality screening and synthesis services for Focus-X with the help of its peptide research and development platform. It also assists Focus-X in obtaining multiple high-quality clinical drug candidates." Dr. Han Dai, CIO and head of Viva BioInnovator, said, "Relying on the founding team's years of extensive research and accumulation, Focus-X has successfully developed an innovative peptide-drug conjugate (PDC) platform for the coupling of radionuclides in just two years. This development has advanced multiple nuclide-PDC pipelines into PCC and IIT stages, forming synergy with Full-Life Technology's international layout in R&D, clinical, and supply chain of radiopharmaceutical drugs." Fa Liu, Ph.D., co-founder and CEO of Focus X, commented, "I am very grateful for the trust and support of Viva and other investment institutions. Within two years, we have achieved breakthroughs and transformations from zero to multiple clinical candidate molecules, some of which have shown very positive early human data. We have accelerated all the processes from verifying scientific hypotheses, transformation, and optimization, to determining clinical candidate molecules through Viva's peptide and synthetic chemistry capabilities. Full-Life's integrated platforms will provide the manufacturing technology, logistics, and clinical development expertise to accelerate the development of our compounds as well as expand our discovery efforts." "The Focus-X acquisition perfectly leverages Full-Life's radiotechnology and development platform.This deal will bring two development ready compounds, including a lead with initial human data, a robust pipeline and world class peptide discovery capabilities to Full-Life," said Lanny Sun, Co-founder, Chairman and CEO of Full-Life. About Viva Biotech Holdings Established in 2008, Viva Biotech (01873.HK) provides one-stop services ranging from early-stage Structure-Based Drug R&D to commercial drug delivery to global biopharmaceutical innovators. We offer leading early-stage to late-phase drug discovery expertise by integrating our dedicated team of experts, cutting-edge technology platforms, and state-of-the-art equipment in X-ray crystallization, Cryo-EM, ASMS, SPR, HDX, CADD, etc.. Our business covers all aspects of therapeutic strategies and drug modalities including small molecules and biologics across the pharma and biotech spectrum. Through our subsidiary Langhua Pharma, we offer our worldwide pharmaceutical and biotech partners One-Stop integrated CMC (Chemical, Manufacturing, and Control) service from preclinical to commercial manufacturing. In addition, Viva has embedded an equity for service (EFS) model to high potential startups to address unmet medical needs. About Focus-X Founded in 2020, Focus-X has developed a proprietary engineering platform to develop peptide radioligands that precisely deliver alpha or beta emitters to breakdown cancer cell DNA. The platform optimizes peptide radioligand vectors for key pharmaceutical attributes such as biodistribution, binding affinity, and in vivo stability. Such optimization can present significant challenges to other ligand targeting compounds such as antibodies. The company focuses on both validated targets and new mechanisms. About Full-Life Technologies Full-Life Technologies Limited ("Full-Life") is a fully integrated global radiopharmaceutical company with operations in Europe and China. We seek to own the entire value chain for radiopharmaceutical research & development, production & commercialization in order to deliver clinical impact for patients. The company plans to attack core issues affecting radiopharmaceuticals today through innovative research that targets the treatments of tomorrow. We are comprised of a team of fast-moving entrepreneurs and scientists with a demonstrated track record in the life sciences, as well as radioisotope research and clinical development. SOURCE Viva Biotech Holdings