Delving into the Latest Updates on Kereos, Inc. with Synapse

Overview

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Neoplasms

Small molecule drug

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Disease Domain	Count

Neoplasms	1

Top 5 Drug Type	Count

Small molecule drug	1

Mn(II) complexes of 1,4,7,10,13-pentaazacyclopentadecane ligands are SOD catalysts in which C-substituents on the ligand effect both SOD activity and stability: increasing the number of substituents increases the stability of the complexes while catalytic activity responds unpredictably.Mechanistic studies revealed that these catalysts function via a catalytic cycle in which oxidation of Mn(II) is rate-determining via a H+-coupled electron transfer from a water bound on the Mn(II)(OH₂) center to HO₂.generating H₂O₂ and Mn(III)(OH), which is rapidly (diffusion-controlled) reduced to Mn(II) generating O₂.This path necessitates that the Mn(II) center have a geometry similar to the oxidized Mn(III) product; thus, accommodating the fast rates we observe for this oxidationMol. mechanics calculations were utilized to probe how ligand substituents influence relative energetics of their Mn(II) complex, altering their geometry.The ability of the ligands to fold about Mn(II) ion adopting a 6-coordinate pseudo-Oh geometry-as required by Mn(III)- correlates with the rate constants for the electron transfer process.

100 Deals associated with Kereos, Inc.

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100 Translational Medicine associated with Kereos, Inc.

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Pipeline

Pipeline Snapshot as of 16 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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