Intervention Study on Fecal Microbiota Transplantation and Transcranial Magnetic Stimulation for Improving Core Symptoms in Children and Adolescents with Autism Spectrum Disorder

Start Date01 May 2025

Sponsor / Collaborator

Tianjin Anding Hospital

NCT06812923

/ RecruitingNot ApplicableIIT

The Study on Effectiveness and Mechanisms of Transcranial Alternating Current Stimulation in Treating Increased Inflammatory Activity Refractory Depression

This study is a randomized controlled trial with a duration of 12 weeks (4 weeks of intervention + 8 weeks of follow-up). The participants are patients with treatment-resistant depression (TRD) and high inflammatory activity (n=52). The study aims to clarify the effectiveness of 15mA, 77.5Hz transcranial alternating current stimulation (tACS) in treating TRD with high inflammatory activity by comparing the changes in depressive symptoms and biological markers after active tACS stimulation versus sham stimulation. Additionally, the study seeks to explore potential underlying mechanisms of action.

Start Date01 Jan 2025

Sponsor / Collaborator

Tianjin Anding Hospital

NCT06692361

/ RecruitingNot ApplicableIIT

Assessment of the Effectiveness and Safety of Fecal Microbiota Transplantation (FMT) in Patients with Major Depressive Disorder Who Do Not Show Early Improvement Following Antidepressant Treatment: a Multicenter, Randomized, Double-Blind, Placebo-Controlled Study

This study aimed to evaluate the efficacy and safety of fecal microbiota transplantation (FMT) in patients with major depressive disorder (MDD) who exhibit suboptimal early response to antidepressant treatment. Additionally, it sought to investigate the impact of FMT on biological indicators, including intestinal microbiota and metabolites, in individuals with MDD

Start Date01 Jan 2025

Sponsor / Collaborator

Capital Medical University

[+3]

100 Clinical Results associated with Tianjin Anding Hospital

0 Patents (Medical) associated with Tianjin Anding Hospital

523

Literatures (Medical) associated with Tianjin Anding Hospital

01 Jul 2025·Journal of Affective Disorders

Factors associated with suicidal ideation in drug-naïve patients with major depressive disorder

Article

Author: Li, Shuhua ; Li, Jie ; Liu, Xueying ; Zhang, Chuhao ; Gao, Ying ; Zhou, Chi ; Li, Meijuan ; Liu, Yanan

BACKGROUNDInflammation and immune activation may be involved in the pathological processes of depression, but its role in suicidal ideation (SI) in major depressive disorder (MDD) remains to be elucidated. The present study aims to examine the differences of inflammatory markers between MDD patients with and without SI, and to construct a predictive panel using multi index to distinguish SI in MDD patients.METHODSA total of 151 first-episode drug-naïve MDD patients were recruited for this study. SI was identified using the Chinese Version of Beck Scale for Suicide Ideation (BSI-CV). Based on the results of this scale, the subjects were divided into two groups: MDD with SI (n = 91) and MDD without SI (n = 60). Hamilton Depression Rating Scale-17 (HAMD-17) was used to assess depression symptoms. Plasma concentrations of interleukin-6 (IL-6), tumor necrosis factor (TNF-α), superoxide dismutase (CAT), and superoxide dismutase (SOD) have been measured.RESULTSAge (OR = 0.87, 95%CI 0.81-0.93, p < 0.001), HAMD retardation factor score (OR = 1.49, 95%CI 1.18-1.88, p < 0.001), and plasma IL-6 concentration (OR = 1.03, 95%CI 1.00-1.06, p = 0.041) were statistically significant on SI in MDD patients, we constructed a good predictive panel to distinguish SI in patients with MDD by combining age, marital status, HAMD retardation factor score, and plasma IL-6 concentration (AUC = 0.812, p < 0.001).LIMITATIONSThe study was cross-sectional, making it impossible to determine directionality or causality.CONCLUSIONSPatients with younger age, single status, serious retardation symptom, and higher plasma IL-6 concentrations are more susceptible to experiencing SI in MDD.

01 Jul 2025·Journal of Affective Disorders

Analysis of maintenance pharmacotherapy in Chinese bipolar disorder patients: Guideline concordance and adjunctive medication use

Article

Author: Zhu, Yuncheng ; Li, Mingli ; Pan, Miao ; Fang, Yiru ; Li, Wenfei ; Wu, Chuangxin ; Chen, Xiuzhe ; Li, Na ; Gan, Zhaoyu ; Sun, Jing ; Wang, Zuowei ; Wang, Yumei ; Hong, Liu ; Hu, Shaohua ; Zhou, Jia ; Xu, Guiyun ; Zhang, Jian ; Chen, Zhiyu ; Wu, Haishan ; Zhang, Yong ; Ma, Yantao ; Li, Xiaohong ; Lin, Jiansen ; Wang, Xiaoping ; Jiao, Zhian ; Li, Yang ; Qin, Yan ; Chen, Jingxu

OBJECTIVEWe collected maintenance treatment medication information from Chinese multicenter bipolar disorder patients, exploring the characteristics of medication use and related factors. We analyzed medication guideline adherence and compared trends in medication use with a study from 2014.METHODS323 patients receiving maintenance therapy for bipolar disorder across 20 hospitals have been recruited. Their prescription information was collected to compare with the recommended drug protocols outlined by CANMAT to assess consistency. Additionally, descriptive statistics were conducted to document the quantities and percentages of different classes of medications used. Regression analysis was employed to explore factors influencing medication choices.RESULTThe rate of medication inconsistency in this study was 12.38 %, characterized by inappropriate use of antidepressants and mood stabilizers. The rate of using additional drugs was 67.80 %, with antipsychotics being the most common adjunctive treatment in the Bipolar I group and antidepressants in the Bipolar II group. Factors influencing the occurrence of adjunctive therapy included previous hospitalization, most recent episode type, and gender. The rate of polypharmacy was 47.10 %, with previous hospitalization and most recent episode type being the main influencing factors.CONCLUSIONThere has been a noticeable improvement in guideline concordance in medication use compared to 2014; however, improper use of antidepressants remains a significant clinical issue. The increasing prevalence of adjunctive medication use underscores the need for more personalized medication recommendations in clinical guidelines.

01 Jul 2025·Journal of Affective Disorders

Clinical correlates, lipid metabolic parameters and thyroid hormones are associated with abnormal glucose metabolism in first-episode and drug-naïve major depressive disorder patients with suicide attempts: A large cross-sectional study

Article

Author: Zhang, Xiang-Yang ; Wang, Jing ; Lang, XiaoE ; Chen, Shiwang

BACKGROUNDThe factors associated with glucose disturbances in major depressive disorder (MDD) patients with comorbid suicide attempts remains unclear. To the best of our knowledge, this is the first study with a large sample size to examine risk factors for glucose disturbances, including clinically relevant factors, lipid metabolic parameters, and thyroid hormone levels in first-episode drug-naïve (FEDN) MDD patients with comorbid suicide attempts.METHODSA total of 1718 FEDN MDD patients were enrolled. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) were used to assess the clinical symptoms of the patients. Fasting blood samples were collected and biochemical parameters were measured, including fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), thyroid stimulating hormone (TSH), free thyroxine (FT4, FT3), anti-thyroid autoantibodies (TgAb), and thyroid peroxidase antibody (TPOAb). Statistical analyses were performed using multivariate logistic regression analyses and receptor operating characteristic curves.RESULTSThe prevalence of glucose disturbances was 24 % in MDD patients with comorbid suicide attempts, which was 1.88 times higher than that in MDD patients without suicide attempts (11 %). Among MDD patients with comorbid suicide attempters, compared with patients without glucose disturbances, patients with glucose disturbances had higher mean scores on the HAMA, HAMD and PANSS positive subscale scores, and higher mean levels of TC, TG, TSH, HDL-C, LDL-C, and TPOAb. The combination of HAMA score, HAMD score, PANSS positive subscale score and TSH distinguished between patients with and without glucose disturbances.CONCLUSIONSOur findings suggest a high prevalence of glucose disturbances in FEDN MDD patients with comorbid suicide attempts. Several clinical correlates, lipid metabolism parameters, and thyroid hormone function are associated with glucose disturbances in MDD patients with comorbid suicide attempts.

100 Deals associated with Tianjin Anding Hospital

100 Translational Medicine associated with Tianjin Anding Hospital

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