Hubei Huashitong Biomedical Technology Co., Ltd.

main purpose: To assess the safety and tolerability of single and multiple oral administrations of WS012 in healthy Chinese adult subjects. Secondary purpose: To evaluate the pharmacodynamics of WS012 in total bile acids (TBA) and fecal TBA following single and multiple oral administrations in healthy adult subjects in China. Exploratory purpose: Explore the effects of multiple oral administrations of WS012 on blood lipids (TG, TC, HDL-C, LDL-C) in healthy subjects.

Preliminary evaluation of the efficacy and safety of WS016 dry suspension in the treatment of hyperkalemia.

Main objective: To evaluate the tolerability and safety of single-dose-escalation and multiple-dose-escalation oral administration of WS016 in healthy subjects. Secondary objectives: To study the pharmacodynamic (PD) characteristics of single dose escalation and multiple dose escalation of oral WS016 in healthy subjects, to evaluate the changes in serum potassium, urine and fecal excretion of potassium concentration from baseline, as II Provide the basis for the dosing regimen of clinical trials. Exploratory purpose: To explore the effect of oral administration of WS016 on blood electrolytes (sodium, magnesium, calcium) in healthy subjects.