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Endocrinology and Metabolic Disease

Monoclonal antibody

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A glimpse into the focused therapeutic areas

Technology Platform

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Targets

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Disease Domain	Count

Endocrinology and Metabolic Disease	1

Top 5 Drug Type	Count

Monoclonal antibody	1

Top 5 Target	Count

SOD1(Superoxide dismutase)	1

We report a male patient with a ruptured persistent primitive trigeminal artery variant aneurysm that resulted in a fistula with the cavernous sinus. He presented with left conjunctival hyperemia and exophthalmos. Cerebral angiography revealed a left direct carotid-cavernous fistula; however, a balloon occlusion test determined that the source was actually a ruptured aneurysm located on the trunk of a persistent primitive trigeminal artery. Endovascular trapping of the persistent primitive trigeminal artery was performed, which resulted in fistula occlusion and symptom resolution.

01 Nov 2024·Journal of Cardiothoracic and Vascular Anesthesia

Right-to-Left Interatrial Shunt Inversion Using a Percutaneous Left Ventricular Assist Device and Extracorporeal Membrane Oxygenation

Letter

Author: Imashuku, Yasuhiko ; Kitagawa, Hirotoshi ; Fukushima, Yutaka ; Inoue, Motoi ; Mizuno, Takayoshi

01 Nov 2024·Cytokine

Case-control study of IL23R rs76418789 polymorphism, smoking, and ulcerative colitis in Japan

Article

Author: Suzuki, Seiyuu ; Andoh, Akira ; Kato, Hiromasa ; Hiraoka, Sakiko ; Nunoi, Hiroaki ; Ikeda, Yoshio ; Hiasa, Yoichi ; Hato, Naohito ; Miyake, Teruki ; Imaeda, Hirotsugu ; Miyake, Yoshihiro ; Kawasaki, Keitarou ; Miura, Hiromasa ; Okada, Hiroyuki ; Tanaka, Keiko ; Yoshimura, Naoki ; Ninomiya, Tomoyuki ; Mizukami, Yuji ; Takeshita, Eiji ; Hokari, Ryota ; Nagata, Chisato ; Higashiyama, Masaaki ; Furukawa, Shinya ; Yamamoto, Yasunori ; Saito, Mitsuru ; Kakimoto, Kazuki ; Yokoyama, Tetsuji ; Higuchi, Kazuhide ; Ohashi, Katsuhisa ; Mori, Kenichiro ; Kumagi, Teru ; Sayama, Koji

BACKGROUNDInterleukin (IL)-23 is involved in the pathogenesis of ulcerative colitis (UC). A genome-wide significant association between IL23R p.G149R (rs76418789) and UC was previously identified in Japan and Korea. This case-control study aims to examine this association within the Japanese population.METHODSThe study included 384 cases diagnosed with UC within the past 4 years and 661 control subjects. Adjustment was made for sex, age, and smoking.RESULTSThe frequency of the AA genotype of rs76418789 was 0.0 % in cases and 0.5 % in control subjects. In comparison to study subjects with the GG genotype of rs76418789, those with the GA or AA genotype had a significantly reduced risk of UC, with an adjusted odds ratio of 0.67 (95 % confidence interval: 0.44-0.999). A significant multiplicative interaction was observed between rs76418789 and having ever smoked influencing UC (p for interaction = 0.03). A significant positive association was found between having ever smoked and UC in individuals with at least one A allele, while no such positive relationship was observed in those with the GG genotype.CONCLUSIONIL23R SNP rs76418789 showed a significant association with UC. This study provides new evidence regarding the interaction between rs76418789 and smoking in relation to UC.

100 Deals associated with Shiga University of Medical Science

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100 Translational Medicine associated with Shiga University of Medical Science

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Pipeline

Pipeline Snapshot as of 26 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

WO2023033049 ( SOD1 )	Nutritional and Metabolic Diseases More	Discovery
FMeC-1 ( APP )	Alzheimer Disease More	Pending
MG1+IRF5-siRNA ( IL-18 )	Neuralgia More	Pending