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Disease Domain	Count

Neoplasms	1
Endocrinology and Metabolic Disease	1
Nervous System Diseases	1

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PPARα x PPARγ	1
CLPP(caseinolytic mitochondrial matrix peptidase proteolytic subunit)	1

Author: Carugno, A. ; Burlando, M. ; Diotallevi, F. ; Pella, P. ; Dal Bello, Giacomo ; Baggini, G. ; Fiorella, C. S. ; Moretta, G. ; Carpentieri, A. ; Galluzzo, M. ; Panasiti, V. ; Fargnoli, M. C. ; Narcisi, A. ; Rizzo, D. ; Sarno, Oriele ; Cozzani, E. ; Campanati, A. ; Zichichi, L. ; Legori, A. ; Calianno, G. ; Esposito, M. ; Graceffa, D. ; De Col, E. ; Cagni, A. E. ; Guarneri, C. ; Brunasso, A. M. G. ; Licciardello, M. ; Vaira, F. ; Cona, F. ; Donnarumma, M. ; Pagnanelli, G. ; Caldarola, Giacomo ; Provenzano, E. ; Musumeci, M. L. ; Rubatto, M. ; Costanzo, A. ; Mola, Federica ; Bianchi, L. ; Dattola, A. ; Travaglini, M. ; Muracchioli, A. ; Di Tano, A. ; Strippoli, D. ; Romita, P. ; Carriero, M. ; Malagoli, P. ; Orsini, D. ; Arancio, L. M. H. ; Musumeci, A. ; Lazzaro Danzuso, Giovanni Carlo ; Campione, E. ; Balestri, R. ; Graziola, F.

31 Dec 2025·The Journal of Maternal-Fetal & Neonatal Medicine

It is time for midwives to perform intrapartum ultrasonography for fetal head station, position and cervical dilation

Article

Author: Yassa, Murat ; Sargın, Mehmet Akif ; Tekin, Arzu Bilge ; Ilter, Pınar Bırol ; Dogan, Ozan ; Kayabasoglu, Furkan ; Eren, Ecem ; Malvası, Antonio

OBJECTIVEDigital vaginal examination (DVE) is a commonly used method in delivery wards to monitor the progress of labor, but it is considered uncomfortable by pregnant women and can lead to infectious complications, such as chorioamnionitis. At the same time, the performance of intrapartum ultrasonography (IPU) is increasing. IPU has a higher inter-observer and intra-observer agreement than DVE. In this study, we evaluated the agreement between IPU and DVE measurements performed by midwives trained in ultrasonography and a specialist obstetrician. Using these data, we assessed the feasibility of midwives administering IPU in delivery rooms for fetal head station and position and cervical dilation.METHODSThis prospective study was conducted on the delivery ward at a tertiary healthcare hospital between 1 March and 1 May 2021. The study included women with low-risk pregnancies with a singleton vertex presentation who were admitted to the delivery ward after 37 weeks of gestation. The two midwives underwent a theoretical and practical training program on patients led by an expert obstetric consultant. Cervical dilation, fetal head station and position were recorded through IPU and DVE measurements conducted by two midwives and one expert obstetrician. Cohen's kappa with squared weights was used to assess the agreement between observers. The discomfort score during the examinations was also obtained from the pregnant women and recorded (0 = no discomfort, 10 = very uncomfortable).RESULTSThe study included 196 pregnant women. There was mostly moderate or substantial agreement between the midwives and obstetric consultant in the variables of cervical dilation, fetal head level and position determined by DVE. In all IPU measurements, these agreements were perfect among all observers. While the intra-observer agreement of the obstetric consultant in IPU and DVE was perfect, in midwives, it was analyzed as substantial in cervical dilation, fair and moderate in the head station, and moderate and perfect in head position. The mean discomfort scores of the pregnant women due to IPU and DVE were 2.89 ± 1.49 and 5.98 ± 2.02, respectively. The differences in discomfort scores between the two examinations were detected to be statistically significant (p < 0.001).CONCLUSIONIPU can be used by midwives in delivery wards to accurately determine the fetal head position and station and cervical dilation without causing discomfort to pregnant women.

31 Dec 2025·Journal of Applied Animal Research

Impact of low-protein diets on broiler nutrition, production sustainability, gene expression, meat quality and greenhouse gas emissions

Author: Bovera, Fulvia ; Tufarelli, Vincenzo ; Shahir, M.H. ; Attia, Youssef A. ; Fahmy, Khaled Nasr El-din ; Salahi, Ahmad

This review explores the effects of low-crude protein diets (LCPD) on broiler chicken production, focusing on sustainability, gene expression, meat quality and environmental impacts.LCPD supplemented with amino acids, enzymes, and probiotics has been shown to influence protein utilization efficiency, meat quality, environmental pollution, and bird welfare.However, gaps exist in the understanding of the relationship between LCPD and immunity, footpad lesions, gut microbiota, economic aspects, and amino acid sparing.LCPD and plant-based protein sources significantly reduced C. perfringens in ileum and cecum, while increasing the abundance Lactobacillaceae.Amino acid digestibility increased in ileum and jejunum with LCPD, and fortification with specific amino acids, while maintaining the non-essential to essential amino acid ratio (NEAAs/ EAAs) at 47:53, resulted in optimal performance.In addition, the reduction of CP to 15% decreased tibia length, calcium retention, and bone mass accumulation.Addnl., 20% excessive total amino acids (TAAs) significantly reduced tibial mineralization.Further research is needed to optimize LCPD formulations and address potential barriers to their implementation in the poultry industry.The available literature emphasizes the effects of LCPD supplemented with amino acids, enzymes, and probiotics.. on broiler performance, protein utilization efficiency, meat quality, environmental pollution, green gas emissions, health, and bird welfare.

100 Deals associated with Ser&Practices

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100 Translational Medicine associated with Ser&Practices

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Pipeline

Pipeline Snapshot as of 03 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

THX-6 ( CLPP )	Diffuse Midline Glioma More	Preclinical
Ligand 10(University of Bari Aldo Moro) ( PPARα x PPARγ )	Diabetes Mellitus, Type 2 More	Preclinical
To042 ( Sodium channels )	Myotonic Disorders More	Pending