Delving into the Latest Updates on Ser&Practices with Synapse

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Nervous System Diseases

Endocrinology and Metabolic Disease

Skin and Musculoskeletal Diseases

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Disease Domain	Count

Endocrinology and Metabolic Disease	1
Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	2

Top 5 Target	Count

Sodium channels	1
PPARα x PPARγ	1

BACKGROUNDLevel of lymph nodes dissection (LND) and inferior mesenteric artery (IMA) ligation is still matter of debate of radical resection of colorectal cancer. This study aims to compare the short-term outcome of three different surgical techniques to treat sigmoid cancer: low ligation (LL) of the IMA with D3-LND, low IMA ligation with D2-LND, and high ligation (HL) of the IMA with D3-LND.METHODSPatients affected by sigmoid colon cancer, who underwent radical resection with three different techniques (LL and D3-LND Group A, HL and D3-LND Group B, and LL with D2 LND- Group C), were included. Operative time (min), blood loss (ml), early postoperative complications, and number of harvested lymph nodes were compared.RESULTSThirty patients per group were enrolled. The median operation time was shorter in group C (130 min, interquartile range [IQR] 120-140), compared with the 245 min (IQR 193.8-295.5) of group A and 257 min (IQR 183-345) of group B, p < 0.005. No significant differences between A and B group were observed in the median intraoperative blood loss, while group C had higher intraoperative blood loss (200 ml, IQR 200-260, p = 0.002). Anastomotic leak occurred in three patients belonging to group B. A reduced number of harvested lymph nodes was registered in Group C (14 lymph nodes, IQR 10-17), p < 0.005.CONCLUSIONSBoth high and low tie ligation with D3-LND for sigmoid cancer can be considered safe and feasible with low rate of postoperative complications, allowing a higher number of harvested lymph nodes compared to low tie ligation with D2 lymphadenectomy.

01 Mar 2025·International Journal of Cardiology

Refining prognosis in Acute Myocarditis: The intersection of imaging and clinical markers

Author: Guaricci, Andrea Igoren ; Pontone, Gianluca

01 Mar 2025·Food Chemistry

Carob (Ceratonia siliqua) leaves: A comprehensive analysis of bioactive profile and health-promoting potential of an untapped resource

Article

Author: Tardugno, Roberta ; Fiore, Donatella ; Serio, Simona ; Piccinelli, Anna Lisa ; Corbo, Filomena ; Santoro, Valentina ; Proto, Maria Chiara ; Clodoveo, Maria Lisa ; Celano, Rita ; Rastrelli, Luca

Carob is a resilient plant with ecological and nutritional significance. A comprehensive study of Ceratonia siliqua leaves (CSL) was conducted to explore its chemical composition and health-promoting potential, aiming at improving the carob-crop sustainability through valorization of this untapped co-product. UHPLC-DAD-HRMS/MS quali-quantitative profiling of CSL revealed high levels of n-galloylated glucoses (129-196 mg g^-1) and flavonol-glycosides (36-42 mg g^-1), with siliquapyranone (39-56 mg g^-1), 1,2,3,6-tetragalloylglusose (47-69 mg g^-1) and myricitrin (27-33 mg g^-1) as main markers. Highest bioactive content and antioxidant capacity (5.0 and 3.1 TEAC) was obtained during pods harvesting. Besides significant antioxidant potential, CSL exhibited strong-high inhibitory activity against α-glucosidase, acetylcholinesterase and butyrylcholinesterase (IC₅₀, 0.51, 13.5 and 58.0 μg mL^-1, respectively). 1,2,3,6-tetragalloylglusose and siliquapyranone are the main contributors to antioxidant and α-glucosidase inhibitory capacities. Excellent ability of extract and 1,2,3,6-tetragalloylglusose (IC₅₀, 0.05 μM) in selectively inhibiting α-glucosidase, make them promising candidates to manage hyperglycemia with fewer side effects.

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Pipeline

Pipeline Snapshot as of 23 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

To042 ( Sodium channels )	Myotonic Disorders More	Preclinical
Ligand 10(University of Bari Aldo Moro) ( PPARα x PPARγ )	Diabetes Mellitus, Type 2 More	Preclinical