Objective: To analyze the effect of compound tea polyphenol gargle combined with Kangfuxin solution on the levels of matrix metalloproteinase-8 (MMP-8) and matrix metalloproteinase-13 (MMP-13) in children with chronic periodontitis. Methods: A total of 120 children with chronic periodontitis admitted to Jinhua Central Hospital from March 2020 to March 2021 were selected as the study subjects, and were randomly divided into a control group and an observation group with 60 cases each. Both groups of children received routine treatment such as oral hygiene guidance, root surface leveling, supragingival and subgingival scaling. The control group was given Kangfuxin solution on the basis of the above, and the observation group was given compound tea polyphenol gargle on the basis of the control group. MMP-8, MMP-13, MMP-3, interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and transforming growth factor-β (TGF-β), the periodontal pocket probe depth (PD), sulcus bleeding index (SBI), attachment level (AL), osteocalcin (BGP), C-terminal peptide of type I collagen (CXT), and N-terminal peptide of type I procollagen (PINP) were detected in the two groups, and were used to calculate the clin. treatment effects in the two groups. Results: Compared with before treatment, the levels of MMP-8, MMP-13, MMP-3, IL-6, MCP-1, PD, SBI, AL and CXT in the two groups decreased after treatment, and the levels of TGF-β, BGP and PINP in the observation group increased, and were significantly higher than those in the control group (P < 0.05). The effective rate of the observation group was higher than that of the control group (P < 0.05). Conclusion: The combination of compound tea polyphenol gargle and Kangfuxin solution can reduce the levels of MMP-8 and MMP-13 in children with chronic periodontitis, alleviate inflammatory reaction, and improve bone metabolism and periodontal indicators.