Wuhan Binhui Biotechnology Co., Ltd. Biological Innovation Park Branch

To evaluate the efficacy of intratumoral OH2 injection combined with mFOLFOX in the treatment of subjects with unresectable advanced or metastatic biliary tract cancer who have failed at least one line of standard therapy.

To evaluate the effectiveness of OH2 injection combined with capecitabine as first-line maintenance treatment for advanced colorectal cancer

Primary purpose: 1. To evaluate the effectiveness of OH2 injection in the treatment of patients with unresectable or metastatic melanoma who have failed at least two lines of standard treatment, using salvage chemotherapy or best supportive care (BSC) selected by the investigator as a control. Secondary purpose: 1. To evaluate the safety of OH2 injection in the treatment of patients with unresectable or metastatic melanoma who have failed at least two lines of standard treatment, using salvage chemotherapy or best supportive care (BSC) selected by the investigator as a control. 2. To evaluate the immunogenicity of OH2 injection in melanoma patients.