Delving into the Latest Updates on Scotgen Ltd. with Synapse

Overview

This article attempts to review recent developments in the rapidly developing field of phage display libraries. The current state of peptide, antibody, and cDNA libraries, as well as current and future applications of phage display libraries are discussed. The main focus of the article is on the methods for selecting binding ligands against targets in a variety of different formats. These include solid phase and in-solution selection methods, and the strategies used to select for higher affinity, and binding ligands against impure and cellular target proteins.

01 Mar 1991·Nature Biotechnology

Reshaping a Human Monoclonal Antibody to Inhibit Human Respiratory Syncytial Virus Infection in Vivo

Article

Author: Lambert, M ; Furze, J M ; Carr, F J ; Taylor, G ; Tempest, P R ; Bremner, P ; Harris, W J

We transferred the complementarity determining regions from a murine monoclonal antibody that neutralizes infection by respiratory syncytial virus (RSV) to a human IgG1 monoclonal antibody. The resulting reshaped human antibody lost affinity for RSV, but an additional alteration to one of the framework regions restored binding affinity and specificity. This second generation reshaped human monoclonal antibody cross-reacted with all clinical isolates of RSV tested and both prevented disease and cured mice even when administered four days after infection. We expect the antibody will prove useful in the management of this major childhood disease.

01 Dec 1990·Biochemical Society TransactionsQ2 · BIOLOGY

Development of a simple dipstick for measurement of apolipoproteins

Q2 · BIOLOGY

Article

Author: CARR, FRANCIS J. ; FAWCETT, PREMALA H. ; FORSTER, SIMON J. ; HARRIS, WILLIAM J.

Plasma apolipoproteins were determined by a dipstick method based on the technique of immunocapillary migration.Antibodies immobilized on the stick capture apolipoprotein A1 or B from the sample as it migrates.Visualization was performed by using an enzyme-labeled 2nd antibody or an enzyme-labeled apolipoprotein which acts as a tracer.

100 Deals associated with Scotgen Ltd.

Login to view more data

100 Translational Medicine associated with Scotgen Ltd.

Login to view more data

Corporation Tree

Boost your research with our corporation tree data.

login

or

view full example data

Boost your research with our corporation tree data.

Pipeline

Pipeline Snapshot as of 10 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Other

2

Login to view more data

Current Projects

Drug(Targets)	Indications	Global Highest Phase

CMV monoclonal antibody(Scotgen [Ceased])	Cytomegalovirus Infections More	Discontinued
Felvizumab ( RSV F protein )	Respiratory Syncytial Virus Infections More	Discontinued