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Overview

This article attempts to review recent developments in the rapidly developing field of phage display libraries. The current state of peptide, antibody, and cDNA libraries, as well as current and future applications of phage display libraries are discussed. The main focus of the article is on the methods for selecting binding ligands against targets in a variety of different formats. These include solid phase and in-solution selection methods, and the strategies used to select for higher affinity, and binding ligands against impure and cellular target proteins.

01 Dec 1990·Biochemical Society TransactionsQ2 · BIOLOGY

Development of a simple dipstick for measurement of apolipoproteins

Q2 · BIOLOGY

Article

Author: CARR, FRANCIS J. ; FAWCETT, PREMALA H. ; FORSTER, SIMON J. ; HARRIS, WILLIAM J.

Plasma apolipoproteins were determined by a dipstick method based on the technique of immunocapillary migration.Antibodies immobilized on the stick capture apolipoprotein A1 or B from the sample as it migrates.Visualization was performed by using an enzyme-labeled 2nd antibody or an enzyme-labeled apolipoprotein which acts as a tracer.

Reconstruction of antibodies

Author: Hamilton, A. ; Adair, J. ; Weir, N. ; Tempest, P. ; Moss, M. ; Fernie, M. ; Forster, S. ; Armour, K. ; Steven, J. ; King, S. ; Carr, F. ; Wallace, T. P. ; Harris, W. ; King, D. ; White, P. ; Mcgregor, D. ; Turner, A.

A review and discussion with 15 referencesThe authors describe the construction of chimeric antibodies; humanization of xenogeneic antibody variable regions; and protocols [CDR substitution to form a humanized antibody variable region sequence; mutagenesis by single-overlap extension PCR (SOE-PCR); and gene assembly PCR].

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Pipeline

Pipeline Snapshot as of 02 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

CMV monoclonal antibody(Scotgen [Ceased])	Cytomegalovirus Infections More	Discontinued
Felvizumab ( RSV F protein )	Respiratory Syncytial Virus Infections More	Discontinued