Zhejiang Zhongyi Pharmaceutical Co., Ltd.

The content of I₂ in CDI tablets was determined by UV-visible spectrophotometry.The iodine in CDI tablets had a maximum absorption at 356 nm by UV-visible spectrophotometry.Linear relations hip is in the range of 12-60 μg/mL^-1.The average recovery was 99.89% and RSD was 0.83%.This method is simple, accurate and reproducible and can be used for the quality control in the process of drug production

Determination of dissolution curve of desloratadine tablets was established.Using 0.01 mol/L and 0.1 mol/L hydrochloric acid solution, pH = 6.8 and 8.0 phosphate buffer solution (PBS) as dissolution medium, absorbance at 282 nm was determinedDissolution curve in 0.01 mol/L and 0.1 mol/L hydrochloric acid solution was similar and it had difference at pH = 6.8 and 8.0phosphate buffer solution (PBS).The method was suitable in determination of dissolution curve of desloratadine tablets.

Objective To establish a HPLC method for determining the impurity α-naphthol content in Duloxetine Hydrochloride Enteric-Coated Capsules.Methods The chromatog. column was the Agilent C₈ column (150 mm × 4.6 mm, 3.5 μm) with the mobile phase of acetonitrile-propanol-buffer solution (2.9 g/L phosphoric acid solution was prepared, adjusting pH to 2.5 with sodium hydroxide solution, taking 1 L of this solution, adding 10.3 g of sodium 1-hexanesulfonate monohydrate, shaking up for complete dissolving) (13:17:70), the flow rate was 1.0 mL/min, the detection wavelength was set at 230 nm and the column temperature was 40°C.Results The injection volume of α-naphthol in the range of 8×10^-4-8×10^-3 μg (r = 0.9976) showed the good linear relation with the peak area.The average recovery rate was 99.25%, RSD = 0.89% (n = 9).Conclusion The established HPLC method was strongly specific, durable and accurate, could be used for the α-naphthol determination in Duloxetine Hydrochloride Enteric-Coated Capsules.