Article
Author: Gaspardone, Achille ; Boccuzzi, Giacomo ; Bertog, Stefan ; Ghassan, Moubarak ; Clapp, Brian ; Della Rocca, Domenico G ; Akin, Ibrahim ; Gheorghe, Livia ; Armero, Sebastien ; Ding, Wern Y ; Galea, Roberto ; Mark, George ; Boersma, Lucas ; Ram, Pradhum ; Schuler, Brian T ; Galache Osuna, Jose G ; Maarse, Moniek ; Ledwoch, Jakob ; Räber, Lorenz ; Nappi, Francesco ; Pershad, Ashish ; Aminian, Adel ; Goyal, Sandeep K ; Güner, Ahmet ; Spence, Mark ; Mesnier, Jules ; Sandri, Marcus ; Gupta, Dhiraj ; Sabbag, Avi ; Cruz-Gonzalez, Ignacio ; Sievert, Kolja ; McKinney, Heather L ; Harvey, James E ; Chen, Weita ; Guerios, Enio ; Santos, Lino ; Afzal, Shazia ; Rodés-Cabau, Josep ; Karabay, Can Y ; Amabile, Nicolas ; de Backer, Ole ; Rosseel, Liesbeth ; Levi, Amos ; Sievert, Horst ; Sabir, Sajjad A ; Moceri, Pamela ; Natale, Andrea ; Schell, Wendy ; Lehmann, Sonja ; Cook, Stephane ; Schmidt, Thomas Robert ; Mansourati, Jacques ; Fernández-Armenta, Juan ; Kornowski, Ran ; Davtyan, Karapet V ; Korsholm, Kasper ; Kühne, Michael ; Nielsen-Kudsk, Jens E ; Nombela-Franco, Luis ; Ebelt, Henning ; Ellis, Christopher R ; Ancona, Marco B M ; Chugunov, Ivan A ; Rivero-Ayerza, Máximo ; Lee, Oh-Hyun ; Montorfano, Matteo ; Saraste, Antti ; Lempereur, Mathieu ; Langel, Martin ; Jung, Christian ; van der Pals, Jesper ; Skurk, Carsten ; Assa, Hana Vaknin ; Osadchiy, Andrey ; Klein, Norbert ; Kefer, Joelle ; Giannini, Francesco ; Esteban, Pablo P ; Piayda, Kerstin ; de Potter, Tom ; Shin, Seung Y ; Marijon, Eloi ; Abelson, Mark ; Lund, Juha ; Alvarez, Xavier Millán ; Merkulov, Evgeny ; Amat-Santos, Ignacio J ; Kim, Jung-Sun ; Eppinger, Sophie
BACKGROUNDLeft atrial appendage (LAA) occluder embolization is an infrequent but serious complication.OBJECTIVESWe aim to describe timing, management and clinical outcomes of device embolization in a multi-center registry.METHODSPatient characteristics, imaging findings and procedure and follow-up data were collected retrospectively. Device embolizations were categorized according to 1) timing 2) management and 3) clinical outcomes.RESULTSSixty-seven centers contributed data. Device embolization occurred in 108 patients. In 70.4 % of cases, it happened within the first 24 h of the procedure. The device was purposefully left in the LA and the aorta in two (1.9 %) patients, an initial percutaneous retrieval was attempted in 81 (75.0 %) and surgery without prior percutaneous retrieval attempt was performed in 23 (21.3 %) patients. Two patients died before a retrieval attempt could be made. In 28/81 (34.6 %) patients with an initial percutaneous retrieval attempt a second, additional attempt was performed, which was associated with a high mortality (death in patients with one attempt: 2.9 % vs. second attempt: 21.4 %, p < 0.001). The primary outcome (bailout surgery, cardiogenic shock, stroke, TIA, and/or death) occurred in 47 (43.5 %) patients. Other major complications related to device embolization occurred in 21 (19.4 %) patients.CONCLUSIONSThe majority of device embolizations after LAA closure occurs early. A percutaneous approach is often the preferred method for a first rescue attempt. Major adverse event rates, including death, are high particularly if the first retrieval attempt was unsuccessful.CONDENSED ABSTRACTThis dedicated multicenter registry examined timing, management, and clinical outcome of device embolization. Early embolization (70.4 %) was most frequent. As a first rescue attempt, percutaneous retrieval was preferred in 75.0 %, followed by surgical removal (21.3 %). In patients with a second retrieval attempt a higher mortality (death first attempt: 2.9 % vs. death second attempt: 24.1 %, p < 0.001) was observed. Mortality (10.2 %) and the major complication rate after device embolization were high.
