ITM Medical Isotopes GmbH

Garching / Munich, Germany, January 16, 2024 – ITM Isotope Technologies Munich SE (ITM), a leading radiopharmaceutical biotech company, today announced the appointment of Dr. Mark Harfensteller to its Executive Board. Dr. Harfensteller initially joined the ITM Group as Head of Engineering in 2008. He has been appointed as head of production in 2009. Additionally, he became responsible for Research and Development (R&D) in 2011. Since 2016, he has held the position of Chief Operating Officer (COO) and Managing Director of ITM Medical Isotopes GmbH, a subsidiary of ITM SE. Under Dr. Harfensteller’s leadership, the company established an industrial and Good Manufacturing Practice (GMP) compliant production system to meet the increasing demand for medical radioisotopes. He played a significant role in the establishment of ITM’s NOVA facility, the world's largest Lutetium-177 (177Lu) production site and the launch of Actineer™ Inc., ITM’s joint venture with Canadian Nuclear Laboratories (CNL) for the global production of Actinium-225 (225Ac). As a member of ITM’s Executive Board, Dr. Harfensteller joins ITM’s primary leadership level currently consisting of Steffen Schuster, Chief Executive Officer (CEO), Dr. Klaus Maleck, Chief Financial Officer (CFO), and Dr. Sebastian Marx, Chief Business Officer (CBO). As a Societas Europaea (“SE”) entity, ITM SE is governed by a two-tier board structure consisting of an Executive Board and a Supervisory Board, in which the latter oversees the Executive Board. Under this framework, the Executive Board is comprised of members of the management team, while the Supervisory Board is generally controlled by shareholders. “Mark has been instrumental in achieving our position as an international leader in the production and supply of medical radioisotopes. We greatly value his contributions to the company over the past fifteen years and cordially welcome him to the Board. His expertise in establishing industrial production chains and his knowledge of the radiopharmaceutical space will help expand our manufacturing capabilities thereby increasing the number of partners and patients we serve,” said Steffen Schuster, CEO of ITM. Commenting on his appointment, Dr. Mark Harfensteller, COO of ITM, added, “I have had the pleasure of contributing to the development of ITM’s Lu-177 n.c.a production capability and the transition into a global provider of medical radioisotopes with an innovative radiopharmaceutical pipeline. Building upon the accomplishments of the past year including the opening of our NOVA facility and the launch of Actineer™ Inc., I look forward to shaping the further growth of the company as a member of ITM's Executive Board.” Before joining ITM, Dr. Harfensteller worked as a consultant and researcher in the fields of radioisotope development and production for Ac-225. He holds a PhD in Mechanical Engineering from the Technical University of Munich (TUM). His work in a team of scientists at TUM’s Institute of Machine Tools and Industrial Management on the development and production of 225Ac via the irradiation of Radium-226 (226Ra) in a cyclotron was nominated for the “Deutscher Zukunftspreis” or “German Future Prize” which is regarded as one of the most prestigious awards for science and innovation in Germany. ITM Isotope Technologies Munich SE ITM, a leading radiopharmaceutical biotech company, is dedicated to providing a new generation of radiomolecular precision therapeutics and diagnostics for hard-to-treat tumors. We aim to meet the needs of cancer patients, clinicians and our partners through excellence in development, production and global supply. With improved patient benefit as the driving principle for all we do, ITM advances a broad precision oncology pipeline, including two phase III studies, combining the company’s high-quality radioisotopes with a range of targeting molecules. By leveraging our nearly two decades of pioneering radiopharma expertise, central industry position and established global network, ITM strives to provide patients with more effective targeted treatment to improve clinical outcome and quality of life. ITM Contact Corporate Communications Svenja Gärtner / Gerrit Siegers Phone: +49 89 329 8986 1502 Email: communications@itm-radiopharma.com Investor Relations Ben Orzelek Phone: +49 89 329 8986 1009 Email: investors@itm-radiopharma.com Attachments 20240116_New Management Board Member_Harfensteller Dr. Mark Harfensteller Dr. Mark Harfensteller Dr. Mark Harfensteller

Garching / Munich, Germany, October 24, 2023 – ITM Isotope Technologies Munich SE (ITM), a leading radiopharmaceutical biotech company, today reported on its participation at the 3rd International Centers for Precision Oncology (ICPO) Forum for Theranostics in Precision Oncology which took place in Garching near Munich, Germany, from October 12-13, 2023. The company also announced support for the ICPO’s newly established Academy for Theranostics, which was unveiled as part of the event. The hosting organization, ICPO is an independent German foundation working on progressing access to Radiomolecular Precision Oncology (RPO) diagnostics and treatments for cancer patients globally. Over 200 international participants were in attendance from fields including oncology, nuclear medicine, and patient advocacy. The event took place in the Science Congress Center Munich, a location neighboring ITM’s headquarters and production facilities for n.c.a. Lutetium-177. ITM participated in the Forum to share key insights for production and supply measures as a leading expert in Radiopharmaceutical Therapy (RPT). Company representatives also presented the esteemed Maurits W. Geerlings Next Generation Award and contributed to the launch of the ICPO Academy for Theranostics. Dr. Michael Siegl, Product Manager at ITM, presented the company’s strategy for meeting future demand through capacity expansion during a “Production and Delivery: Radiomolecular Theranostics at the Cross-roads” speaker session. Dr. Siegl reviewed how ITM applies its expertise as the world’s largest manufacturer of the highly coveted n.c.a. Lutetium-177 to ensure it is prepared to address future demand for Actinium-225 as alpha-emitting isotopes become increasingly important. As part of the conference, Richard Henkelmann, Managing Director of ITM’s subsidiary ITM Medical Isotopes, had the honor of presenting the 2nd Maurits W. Geerlings Next Generation Award for outstanding research and contributions in Actinium-225 radiopharmaceuticals to Dr. Sanjana Ballal, Research Associate-Medical Physicist at the All India Institute of Medical Sciences (AIIMS) in New Delhi, India, and Dr. Mariza Vorster, Head of the Clinical Department and Associate Professor at the Kwa-Zulu Natal and Inkosi Albert Luthuli Hospital in South Africa. Dr. Geerlings, co-founder and the first Chairman of ITM, was a pioneer in the field of theranostics and launched ITM together with co-founders, Mr. Henkelmann and Mr. Oliver Buck to develop innovative radiopharmaceuticals for the diagnosis and treatment of cancer. ITM also announced its support for the ICPO Academy for Theranostics, which was unveiled at the event. With over 30 contributing experts, this training platform offers approximately 50 hours of video-based e-learning education to physicians, medical physicists, radiochemists and nurses interested in applying radiotheranostics to their clinical practice. The program, comprised of three workstreams, culminates with participants passing all training modules and being awarded an international RPO certificate. As part of a two months pilot phase involving over 700 participants from 300 hospitals, the first 340 certificates were granted to participants who had successfully completed the first level of the course, thereby earning an international certificate in the fundamental theoretical training of RPT in precision oncology. As part of a public private partnership with the Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ GmbH), ITM has been significantly supporting and thus enabling the development of the pilot phase. The company has furthermore pledged to bolster the program with 100-150 stipends per year to provide participants with full access to the online educational program in order to obtain the final certificate. Additionally, ITM will assist the ICPO in expanding the availability of the training program to various geographies including India as a next step in its continued development of the program. “We highly value the opportunity to participate in the ICPO forum with other experts in the field and are honored to support the launch and growth of the ICPO Academy for Theranostics. The number of promising new diagnostics and therapeutics being developed in nuclear medicine is on the rise. Educational programs like the Academy will ensure that highly trained experts are able to apply these methods to provide patients around the world with improved care and outcomes,” commented Steffen Schuster, CEO of ITM. About ITM Isotope Technologies Munich SE ITM, a leading radiopharmaceutical biotech company, is dedicated to providing a new generation of radiomolecular precision therapeutics and diagnostics for hard-to-treat tumors. We aim to meet the needs of cancer patients, clinicians and our partners through excellence in development, production and global supply. With improved patient benefit as the driving principle for all we do, ITM advances a broad precision oncology pipeline, including two phase III studies, combining the company’s high-quality radioisotopes with a range of targeting molecules. By leveraging our nearly two decades of pioneering radiopharma expertise, central industry position and established global network, ITM strives to provide patients with more effective targeted treatment to improve clinical outcome and quality of life. www.itm-radiopharma.com ITM Contact Corporate Communications Svenja Gärtner / Gerrit Siegers Phone: +49 89 329 8986 1502 Email: communications@itm-radiopharma.com Investor Relations Ben OrzelekPhone: +49 89 329 8986 1009Email: investors@itm-radiopharma.com Attachment 20231024_ PR_ITM ICPO Forum and Academy

Tiverton, Ontario, Oct. 24, 2022 (GLOBE NEWSWIRE) -- An international collaboration between Bruce Power, Isogen (a Kinectrics and Framatome company) and ITM Isotope Technologies Munich SE (ITM), announced today the commencement of commercial production of lutetium-177. The announcement was celebrated at ITM’s headquarters in Munich, Germany, along with representatives of the partnership organizations during a trade mission with Vic Fedeli, Ontario’s Minister of Economic Development, Job Creation and Trade. This milestone was achieved following completion of final commissioning and regulatory approval from the Canadian Nuclear Safety Commission and is the culmination of a multi-year project to install a novel Isotope Production System (IPS) in Bruce Power’s Unit 7. It marks the first-of-its-kind achievement of a commercial power reactor with additional capability to commercially produce short-lived medical isotopes. The IPS will provide reliable, industrial-scale production of lutetium-177, a medical isotope used for targeted cancer therapeutics. Lutetium-177 is used to deploy precision nuclear medicine that precisely targets malignant cells while sparing surrounding healthy tissues. “Ontario’s nuclear industry supports thousands of high-skilled jobs and is at the forefront when it comes to innovation,” said Premier Doug Ford. “Today’s announcement is a huge step forward in advancing Ontario as a world leader of isotope production in the fight against cancer. This unique international project using Made-in-Ontario infrastructure will help doctors and patients at home and around the world have greater access to the life-saving isotopes they need.” “It is with great pride that we at Bruce Power, along with our partners at Isogen, ITM and Saugeen Ojibway Nation, celebrate the successful commencement of commercial operation of the world’s first large-scale Isotope Production System for the production of lutetium-177,” said Mike Rencheck, Bruce Power’s President and CEO. “This announcement is the result of years of dedication and comes thanks to the hard work and innovative spirit of thousands of employees across this unique international partnership.” The Made-in-Ontario IPS, designed and installed by Isogen at Bruce Power, irradiates ytterbium-176 to produce lutetium-177, which is then transported to ITM’s manufacturing facility in Germany for processing of pharmaceutical-grade, non-carrier-added lutetium-177 (n.c.a. lutetium-177). ITM is a supplier of n.c.a. lutetium-177 to health care facilities around the world, and the isotope has been successfully used in various clinical and commercial radiopharmaceutical cancer treatments. “Today we celebrate the efforts of Bruce Power, ITM, our Kinectrics staff, and our partner in Isogen, Framatome, whose collective efforts enabled the start of commercial supply of lutetium-177,” said David Harris, CEO of Kinectrics. “This day marks a paradigm shift in medical isotope supply wherein the international medical community can now depend on scalable, reliable, Canadian, power-reactor produced isotopes for their cancer treatments.” The IPS will leverage Bruce Power’s continual operations 24 hours a day, seven days a week to provide a consistent and scalable supply of life-saving isotopes that will be used by doctors to treat cancer patients around the world. “We commemorate this historical accomplishment that promises potentially life-saving medical treatments for cancer patients,” said Bernard Fontana, CEO of Framatome. “Our shared vision with our Isogen partner Kinectrics, and Bruce Power, working with ITM, has led to this significant milestone. We are proud of our teams who have persevered to design, develop, install and implement this ambitious and complex project. As part of our Framatome Healthcare brand, we are honored to play a critical role in ensuring a reliable supply of isotopes, including lutetium-177, to the medical communities around the world.” Commercial operation of the IPS will provide large-scale production of lutetium-177 at a time when global demand for these short-lived isotopes is on the rise. ITM holds a U.S. Drug Master File (DMF) with the FDA for n.c.a. lutetium-177 and has marketing authorization in the EU (brand name EndolucinBeta®). ITM has exclusive access to the irradiation service provided by the IPS for the production of lutetium-177 and will use the increased supply of high-quality isotopes from the IPS to meet the growing demand by physicians and patients. “As the largest global provider of high-quality n.c.a lutetium-177 for therapeutic cancer treatments we are always looking to expand our production network to secure supply to provide access to hospitals and patients worldwide, and this collaboration is a testament to this commitment,” added Steffen Schuster, CEO of ITM. “We are grateful to our partners for this smooth scale up to commercial production which will ensure production security for our own Phase 3 assets as well as our commitment to currently approved targeted radionuclide therapies leveraging lutetium-177.” Vic Fedeli, Ontario’s Minister of Economic Development, Job Creation and Trade, expressed support of the international collaboration and its advancement of Ontario as a global hub for isotope production and innovation. "International partnerships such as this one between Bruce Power, Isogen and ITM are paving the way for future innovation in key sectors in Ontario," said Minister Fedeli. "Congratulations to everyone involved in this milestone achievement in the production of life-saving medical isotopes! Together, we are building Ontario and continuing to ensure the province is a leader in the life sciences sector and the global isotope supply chain.” Bruce Power will collaborate with Saugeen Ojibway Nation to market the new isotope supply in an equity partnership named Gamzook’aamin Aakoziwin. “The Gamzook’aamin Aakoziwin project has been years in the making, and today marks another exciting milestone on the road to help in the global fight against cancer,” said Chief Conrad Ritchie, Chippewas of Saugeen First Nation. “These medical isotopes will be used to help patients receive treatments in the battle against cancer not just at home in our communities, but across the world.” “We are proud to be a part of this innovative project, which will have a positive impact worldwide on the health care community,” said Chief Veronica Smith, Chippewas of Nawash Unceded First Nation. “Working together through this partnership, we are playing a leadership role in the fight against cancer and continuing to increase access to isotopes that are critical to innovative treatment and diagnosis of cancer.” Learn more about how isotopes help to keep hospitals safe, as well as diagnose and treat cancer at . About Bruce Power Bruce Power is an electricity company based in Bruce County, Ontario. We are powered by our people. Our 4,200 employees are the foundation of our accomplishments and are proud of the role they play in safely delivering clean, reliable, low-cost nuclear power to families and businesses across the province and life-saving medical isotopes around the world. Bruce Power has worked hard to build strong roots in Ontario and is committed to protecting the environment and supporting the communities in which we live. Formed in 2001, Bruce Power is a Canadian-owned partnership of TC Energy, OMERS, the Power Workers’ Union and The Society of United Professionals. Learn more at and follow us on Facebook, Twitter, LinkedIn, Instagram and YouTube. About Isogen Isogen is a joint venture between Framatome and Kinectrics, whose mission is to enable the use of CANDU reactors to produce the medical isotopes needed to treat and diagnose patients with serious diseases world-wide. Isogen’s enabling partnerships with Bruce Power and ITM allows us to produce the world’s largest and most reliable supply of life-saving, short-lived, therapeutic medical isotopes. Learn more at and follow us on LinkedIn. About ITM Isotope Technologies Munich SE ITM, a leading radiopharmaceutical biotech company, is dedicated to providing a new generation of radiomolecular precision therapeutics and diagnostics for hard-to-treat tumors. We aim to meet the needs of cancer patients, clinicians and our partners through excellence in development, production and global supply. With improved patient benefit as the driving principle for all we do, ITM advances a broad precision oncology pipeline, including two phase III studies, combining the company’s high-quality radioisotopes with a range of targeting molecules. By leveraging our nearly two decades of pioneering radiopharma expertise, central industry position and established global network, ITM strives to provide patients with more effective targeted treatment to improve clinical outcome and quality of life. Further information at: ITM Medical Isotopes GmbH, a 100% subsidiary of ITM Isotope Technologies Munich SE, had signed a supply arrangement for lutetium-177 with Isogen in 2020. Attachment Isotope Production System begins commercial production of cancer-fighting lutetium-177 John Peevers Bruce Power 5193863799 john.peevers@brucepower.com