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Cohen has illustrated that extremely high Gamma-aminobutyric acid (GABA) levels in the urine and blood and high plasma ammonia were observed for an autistic male child diagnosed with infantile autism. GABA is a major inhibitory neurotransmitter of the mammalian brain and the enzyme responsible for catabolism is GABA-Transaminase (GABA-T). Elevated levels of ammonia in the plasma results in a decrease in the efficiency for the GABA-T enzyme and this results in higher GABA concentrations after regulation in the liver. It is postulated that a link between plasma ammonia and plasma GABA exists where the concentration of GABA in the plasma is directly related to the ammonia plasma concentration. A ratio of approximately 0.30 (plasma ammonia/GABA) is a consistent finding for normal subjects and for subjects with infantile autism and liver diseases such as hepatic encephalopathy.

01 Jul 2002·Medical HypothesesQ4 · MEDICINE

Use of a GABA-transaminase agonist for treatment of infantile autism

Q4 · MEDICINE

Article

Author: Cohen, Brett I

This paper describes the use of a GABA-transaminase agonist for the treatment of infantile autism. An approximate one third reduction of GABA and ammonia levels for an autistic patient with noticeable improvement of verbal/language skills and a reduction of repetitious ritualistic self-stimulatory behavior (stimming) was observed. A reduction of the plasma GABA (by administrating a GABA-T agonist, Imipramine) probably results in more axon(s)-to-oligodendrocyte signaling in the corpus callosum and it is postulated that this could result in a reduction of the autistic features for the patient.

01 Dec 2001·Medical HypothesesQ4 · MEDICINE

GABA-transaminase, the liver and infantile autism

Q4 · MEDICINE

Article

Author: Cohen, B I

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter of the mammalian brain and the enzyme responsible for catabolism (breakdown in the liver during regulation) is GABA-Transaminase (GABA-T). Recently, Cohen has shown that extremely high GABA levels in the urine and blood were observed for an autistic child. The finding that elevated levels of GABA in the urine and blood are present for an autistic child could explain why autistic features (such as self-stimulatory behavior and language delays, etc.) are found. Increasing the GABA-T enzyme activity for this autistic patient could result in less plasma GABA (after liver regulation) entering into the bloodsteam and brain and it is postulated that this could result in a reduction of the autistic features (such as self-stimulatory behavior and language delays, etc.) due to abnormal development of the axon(s) in the corpus callosum.

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Pipeline Snapshot as of 04 Apr 2026

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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