Chengdu Tianshizhen Biotechnology Co., Ltd.

Primary purpose: To evaluate the pharmacokinetic characteristics of TG103 injection after a single subcutaneous injection in subjects with normal renal function and renal insufficiency. Secondary purpose: To evaluate the immunogenicity of TG103 injection after a single subcutaneous injection in subjects with normal renal function and renal insufficiency; To evaluate the safety and tolerability of TG103 injection after a single subcutaneous injection in subjects with normal renal function and renal insufficiency.

Primary objective: To compare the relative bioavailability (BA) of TG103 injection in Chinese healthy subjects after subcutaneous injection at different administration sites. Secondary objective: To evaluate the immunogenicity of TG103 injection in Chinese healthy subjects after subcutaneous injection at different administration sites; To evaluate the safety and tolerability of TG103 injection in Chinese healthy subjects after subcutaneous injection at different administration sites.

Primary objective: To evaluate the effect of multiple administration of TG103 injection on the pharmacokinetics (PK) of metformin hydrochloride tablets in Chinese healthy subjects. Secondary objectives: To evaluate the PK characteristics of multiple administration of TG103 injection in Chinese healthy subjects; To evaluate the immunogenicity of multiple administration of TG103 injection in Chinese healthy subjects; To evaluate the safety and tolerability of TG103 injection and metformin hydrochloride tablets after multiple administration in Chinese healthy subjects.