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Overview

Tags

Neoplasms

Respiratory Diseases

Immune System Diseases

Synthetic peptide

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	3
Immune System Diseases	2
Endocrinology and Metabolic Disease	1
Infectious Diseases	1
Hemic and Lymphatic Diseases	1

Top 5 Drug Type	Count

Synthetic peptide	4
Small molecule drug	2

Top 5 Target	Count

αvβ6(Integrin alpha-V/beta-6)	1
KRAS G12C(GTPase KRas G12C)	1
EphA2(Ephrin type-A receptor 2)	1
SARS-CoV-2 3CLpro(SARS-CoV-2-3C-like-proteinase)	1

Orange carotenoid protein (OCP) of photosynthetic cyanobacteria binds to ketocarotenoids noncovalently and absorbs excess light to protect the host organism from light-induced oxidative damage. Herein, we found that mutating valine 40 in the α3 helix of Gloeocapsa sp. PCC 7513 (GlOCP1) resulted in blue- or red-shifts of 6-20 nm in the absorption maxima of the lit forms. We analyzed the origins of absorption maxima shifts by integrating X-ray crystallography, homology modeling, molecular dynamics simulations, and hybrid quantum mechanics/molecular mechanics calculations. Our analysis suggested that the single residue mutations alter the polar environment surrounding the bound canthaxanthin, thereby modulating the degree of charge transfer in the photoexcited state of the chromophore. Our integrated investigations reveal the mechanism of color adaptation specific to OCPs and suggest a design principle for color-specific photoswitches.

Nature CommunicationsQ1 · CROSS-FIELD

Author Correction: Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo

Q1 · CROSS-FIELD

OA

Author: Kirberger, Steven E ; Ekanayake, Arunika I ; Kelich, Payam ; Choi, Hwanho ; Vederas, John C ; Li, Jiaqian ; Vukovic, Lela ; Sarkar, Susmita ; Derda, Ratmir ; Kharchenko, Serhii ; Wong, Jeffrey Y K ; Miao, Jiayuan ; Kang, Hongsuk ; Nuss, John M ; Kalhor-Monfared, Shiva ; Alvizo-Paez, Edgar R ; Macauley, Matthew S ; Lin, Yu-Shan ; Qiu, Ryan ; Fernandez, Kleinberg X ; John, J Dwyer ; Pomerantz, William C K

Nature CommunicationsQ1 · CROSS-FIELD

Genetically encoded discovery of perfluoroaryl macrocycles that bind to albumin and exhibit extended circulation in vivo

Q1 · CROSS-FIELD

ArticleOA

Author: Kirberger, Steven E ; Ekanayake, Arunika I ; Kelich, Payam ; Choi, Hwanho ; Vederas, John C ; Li, Jiaqian ; Vukovic, Lela ; Sarkar, Susmita ; Derda, Ratmir ; Kharchenko, Serhii ; Wong, Jeffrey Y K ; Miao, Jiayuan ; Kang, Hongsuk ; Nuss, John M ; Kalhor-Monfared, Shiva ; Alvizo-Paez, Edgar R ; Macauley, Matthew S ; Lin, Yu-Shan ; Qiu, Ryan ; Fernandez, Kleinberg X ; John, J Dwyer ; Pomerantz, William C K

AbstractPeptide-based therapeutics have gained attention as promising therapeutic modalities, however, their prevalent drawback is poor circulation half-life in vivo. In this paper, we report the selection of albumin-binding macrocyclic peptides from genetically encoded libraries of peptides modified by perfluoroaryl-cysteine SNAr chemistry, with decafluoro-diphenylsulfone (DFS). Testing of the binding of the selected peptides to albumin identified SICRFFC as the lead sequence. We replaced DFS with isosteric pentafluorophenyl sulfide (PFS) and the PFS-SICRFFCGG exhibited KD = 4–6 µM towards human serum albumin. When injected in mice, the concentration of the PFS-SICRFFCGG in plasma was indistinguishable from the reference peptide, SA-21. More importantly, a conjugate of PFS-SICRFFCGG and peptide apelin-17 analogue (N3-PEG6-NMe17A2) showed retention in circulation similar to SA-21; in contrast, apelin-17 analogue was cleared from the circulation after 2 min. The PFS-SICRFFC is the smallest known peptide macrocycle with a significant affinity for human albumin and substantial in vivo circulation half-life. It is a productive starting point for future development of compact macrocycles with extended half-life in vivo.

100 Deals associated with Quantum Intelligence Corp.

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100 Translational Medicine associated with Quantum Intelligence Corp.

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Pipeline

Pipeline Snapshot as of 12 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

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5

Preclinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

EphA2-RLT(Quantum Intelligence) ( EphA2 )	Ovarian Cancer More	Preclinical
Bromodomains(Quantum Intelligence)	Hematologic Neoplasms More	Preclinical
Mpro Protease(Quantum Intelligence) ( SARS-CoV-2 3CLpro )	COVID-19 More	Preclinical
Integrin avβ6(Quantum Intelligence) ( αvβ6 )	Fibrosis More	Preclinical
KRAS G12C(Quantum Intelligence) ( KRAS G12C )	Non-Small Cell Lung Cancer More	Preclinical