Delving into the Latest Updates on Indian Institute of Integrative Medicine with Synapse

Overview

Tags

Neoplasms

Infectious Diseases

Nervous System Diseases

Small molecule drug

Herbal medicine

Chemical drugs

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	8
Infectious Diseases	7
Nervous System Diseases	3
Immune System Diseases	2
Endocrinology and Metabolic Disease	1

Top 5 Drug Type	Count

Small molecule drug	18
Herbal medicine	2
Chemical drugs	1

Top 5 Target	Count

PI3Kα(Phosphatidylinositol 3 kinase alpha)	2
P-gp(P-glycoprotein 1)	2
IL-6(Interleukin-6)	1
AChE x BACE1 x BChE	1
Tubulin	1

Chromium (Cr) contamination in soils reduces crop yields and poses a remarkable risk to human and plant system. The main objective of this study was to observe the protective mechanisms of exogenously applied melatonin (Mel- 0.05, 0.1, and 0.15 μM) in seedlings of Brassica juncea L. under Cr (0.2 mM) stress. This was accomplished by analysing the plant's morpho-physiological, biochemical, nuclear, membrane, and cellular characteristics, as well as electrolyte leakage. Superoxide, malondialdehyde, and hydrogen peroxide increased with Cr toxicity. Cr also increased electrolyte leakage. Seedlings under Cr stress had 86.4% more superoxide anion and 27.4% more hydrogen peroxide. Electrolyte leakage increased 35.7% owing to Cr toxicity. B. juncea L. cells with high radical levels had membrane and nuclear damage and decreased viability. Besides this, the activities of the antioxidative enzymes, as POD, APOX, SOD, GST, DHAR, GPOX and GR also elevated in the samples subjected to Cr toxicity. Conversely, the activity of catalase was downregulated due to Cr toxicity. In contrast, Mel reduced oxidative damage and conserved membrane integrity in B. juncea seedlings under Cr stress by suppressing ROS generation. Moreover, the activity of antioxidative enzymes that scavenge reactive oxygen species was substantially upregulated by the exogenous application of Mel. The highest concentration of Mel (Mel c- 0.15 μM) applied showed maximum ameliorative effect on the toxicity caused by Cr. It causes alleviation in the activity of SOD, CAT, POD, GPOX, APOX, DHAR, GST and GR by 51.32%, 114%, 26.44%, 48.91%, 87.51%, 149%, 42.30% and 40.24% respectively. Histochemical investigations showed that Mel increased cell survival and reduced ROS-induced membrane and nuclear damage. The findings showed that Mel treatment upregulated several genes, promoting plant development. Its supplementation decreased RBOH1 gene expression in seedling sunder stress. The results supported the hypothesis that Mel concentrations reduce Cr-induced oxidative burst in B. juncea.

25 Jun 2024·Current Pharmaceutical Biotechnology

Emerging Applications of Plant Antimicrobials in the Food Industry

Article

Author: Genovese, Carlo ; Kumar, Sandeep ; Sharma, Ram ; Rohilla, Suman ; Pathak, Anuj ; Malhotra, Anjleena ; Grover, Parul ; Bhardwaj, Monika

Abstract:Food safety is a global concern with significant public health implications. Improper food handling can harbor a wide range of pathogenic organisms. Antimicrobial agents are crucial for controlling microbes and ensuring food safety and human health. The growing demand for natural, safe, and sustainable food preservation methods has driven research into using plant antimicrobials as alternatives to synthetic preservatives. The food industry is now exploring innovative approaches that combine various physical methods with multiple natural antimicrobials. This review aims to outline the evolving applications of plant antimicrobials in the food industry. It discusses strategies for managing bacteria and categorizes different plant antimicrobials, providing insights into their mechanisms of action and structures. This review offers a comprehensive overview of antimicrobial peptides (AMPs), detailing their structural characteristics, mechanisms of action, various types, and applications in food packaging fabrication and explaining how they contribute to food preservation. It highlights the synergistic and additive benefits of plant antimicrobials and their successful integration with food technologies like nanotechnology, which enhances the hurdle effect, improving food safety and extending shelf life. The review also emphasizes the importance of antimicrobial peptides and the need for further research in this area. Safety assessment and regulatory considerations are discussed as well. By addressing these gaps, plant antimicrobials have the potential to pave the way for more effective, safe, and sustainable food preservation strategies in the future.

09 May 2024·Precision Medicine and Human Health

Prevalence of Triple Negative Breast Cancer and its Therapeutic Challenges

Author: Anand, Loveleena Kour ; Maqbool, Mir Shahid ; Malik, Fayaz

Breast cancer (BC) is the most common among females. The current status of BC worldwide shows that more than 1 million women are affected and ~400 000 die every year. Partial success has been achieved by mammography coupled with adjuvant treatment. However, its incidence and mortality both are increasing. Several subcategories of BC have been reported; of which, one is triple-negative breast cancer (TNBC). This is defined by a lack of expression of oestrogen and progesterone receptors and human epidermal growth factor receptor 2 (HER-2). Several approaches have been used for speedy and accurate diagnosis and precise treatment of BC. In this context, precision medicine approach is of great relevance in ameliorating the suffering of the patient’s from the menace of BC. The present chapter aims to provide background information, different types of BC and its sub-types and molecular mechanisms for therapeutic intervention required for precision medicine.

100 Deals associated with Indian Institute of Integrative Medicine

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100 Translational Medicine associated with Indian Institute of Integrative Medicine

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Pipeline

Pipeline Snapshot as of 22 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

20

Preclinical

Other

6

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

IIIM-017	Tuberculosis More	Preclinical
IIIM-209	Tuberculosis More	Preclinical
IIIM-4Q ( mTOR )	Neoplasms More	Preclinical
IIIM-160	Rheumatoid Arthritis More	Preclinical
SB-1448 ( AChE x BACE1 x BChE )	Alzheimer Disease More	Preclinical