Delving into the Latest Updates on The United Bio-Technology(Hengqin) Co., Ltd. with Synapse

Overview

Tags

Endocrinology and Metabolic Disease

Digestive System Disorders

Urogenital Diseases

Synthetic peptide

Recombinant polypeptide

Biosimilar

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Endocrinology and Metabolic Disease	7

Top 5 Drug Type	Count

Biosimilar	4
Synthetic peptide	2
Recombinant polypeptide	2
Hormone	2
Small molecule drug	1

Top 5 Target	Count

GLP-1R(Glucagon-like peptide 1 receptor)	2
INSR(Insulin receptor)	1
NPY2R(Neuropeptide Y receptor type 2)	1
SOST(Sclerostin)	1
GLP-1R x INSR	1

This is a multicenter, randomized, double-blind, placebo-controlled Phase 2 clinical study evaluating the efficacy and safety of UBT251 in MASH subjects. Subjects will be randomly assigned to UBT251 2mg-dose, 4mg-dose，6mg-dose and placebo groups. The entire trial cycle includes a 6-week screening period, a 48-week double-blind treatment period, and a 4-week follow-up period.

Start Date22 Aug 2025

Sponsor / Collaborator

The United Bio-Technology(Hengqin) Co., Ltd.

NCT07134335

/ Active, not recruitingPhase 2

A Phase II Clinical Study to Evaluate the Efficacy and Safety of UBT251 Injection in Obese/Overweight Chronic Kidney Disease (CKD) Population

This multicenter, randomized, double-blind, placebo-controlled phase II clinical study to evaluate the efficacy and safety of UBT251 injection in obese/overweight chronic kidney disease (CKD) population

Start Date11 Jul 2025

Sponsor / Collaborator

The United Bio-Technology(Hengqin) Co., Ltd.

CTR20250029

/ Active, not recruitingPhase 2

评估UBT251注射液在2型糖尿病患者中有效性和安全性的随机、双盲、安慰剂及阳性药平行对照Ⅱ期研究

[Translation] A randomized, double-blind, placebo- and active drug-controlled phase II study to evaluate the efficacy and safety of UBT251 injection in patients with type 2 diabetes

主要目的：在2型糖尿病患者中评价UBT251注射液连续给药24周后的有效性，为Ⅲ期临床试验推荐给药剂量。次要目的：1）评价UBT251注射液连续给药24周在2型糖尿病患者中的安全性；2）评价UBT251注射液在2型糖尿病患者中的药代/药效动力学特征；3）评价UBT251注射液在2型糖尿病患者中的免疫原性特征；4）评价UBT251注射液对2型糖尿病患者胰岛功能的影响。

[Translation]

Primary objective: To evaluate the efficacy of UBT251 injection after 24 weeks of continuous administration in patients with type 2 diabetes and to recommend the dosage for Phase III clinical trials. Secondary objectives: 1) To evaluate the safety of UBT251 injection after 24 weeks of continuous administration in patients with type 2 diabetes; 2) To evaluate the pharmacokinetic/pharmacodynamic characteristics of UBT251 injection in patients with type 2 diabetes; 3) To evaluate the immunogenicity characteristics of UBT251 injection in patients with type 2 diabetes; 4) To evaluate the effect of UBT251 injection on pancreatic islet function in patients with type 2 diabetes.

Start Date15 Mar 2025

Sponsor / Collaborator

The United Bio-Technology(Hengqin) Co., Ltd.

100 Clinical Results associated with The United Bio-Technology(Hengqin) Co., Ltd.

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0 Patents (Medical) associated with The United Bio-Technology(Hengqin) Co., Ltd.

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100 Deals associated with The United Bio-Technology(Hengqin) Co., Ltd.

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100 Translational Medicine associated with The United Bio-Technology(Hengqin) Co., Ltd.

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Pipeline

Pipeline Snapshot as of 04 Sep 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

IND Application

IND Approval

1

Phase 1

Phase 2

1

Phase 3

NDA/BLA

1

Approved

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Liraglutide biosimilar(Zhuhai United Laboratories) ( GLP-1R )	Diabetes Mellitus, Type 2 More	Approved
Semaglutide biosimilar (Zhuhai United Laboratories) ( GLP-1R )	Obesity More	NDA/BLA
Insulin degludec/liraglutide biosimilar (Federal Biotechnology (Zhuhai Hengqin)) ( GLP-1R x INSR )	Diabetes Mellitus, Type 2 More	Phase 3
UBT-251 ( GCGR x GIPR x GLP-1R )	Obesity More	Phase 2
Insulin degludec/Insulin aspart(Federal Biotechnology (Zhuhai Hengqin)) ( INSR )	Diabetes Mellitus, Type 2 More	Phase 1