Delving into the Latest Updates on Nektar Therapeutics UK Ltd. with Synapse

Overview

Tags

Congenital Disorders

Immune System Diseases

Neoplasms

Antibody drug conjugate (ADC)

Fusion protein

Cytokines

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Immune System Diseases	1
Neoplasms	1

Top 5 Drug Type	Count

Antibody drug conjugate (ADC)	1
Fusion protein	1
Cytokines	1

Top 5 Target	Count

IFNγ(Interferon gamma)	1
IL-2Rβ(Interleukin-2 receptor beta chain)	1

In-line anal. of refractive index is required for efficient design and monitoring of supercritical fluid extraction and precipitation processes.A robust method was developed based on measurements of laser beam deviation using an interferometer and image processing system.Data on refractive index of CO₂-EtOH mixtures were obtained at pressures between 70 and 200 bar and temperatures between 308 and 363 K, for continuous flow of premixed solvents and for equilibrium gas phase below the mixture critical pressure.The refractive index of a mixture is a linear function of EtOH mole fraction and can adequately describe mixing and phase behavior in the vessel.For pure CO₂, refractive index was determined as a function of pressure and d. and its Lorentz-Lorenz functions determined

Enhanced drug dissolution using polymer:drug co-formulations prepared by supercritical fluid technology

Author: Kordikowski, A. ; Daintree, Lyn S. ; Jiang, Zhong ; Wilkins, Simon A. ; York, Peter ; Green, Jennifer A.

Polymer:drug co-formulations are often used in pharmaceuticals to improve drug bioavailability by enhancing wettability and modifying the release profile for poorly water-soluble drug mols.This work examines poorly water-soluble drug mols. co-formulated using Nektar Supercritical Fluid Technol.^TM.Present conventional technol. does not allow control of particle characteristics.The purpose of this study was thus to show that supercritical fluids offer an alternative approach to conventional drug-polymer co-formulation because particle characteristics such as size, residual solvent and morphol. can be directed.Using this technol., the drug particles can be dispersed as a solid solution or as a semi-crystalline dispersion within the release-modifying polymer.A single solution containing the dissolved drug and polymer was fed together with supercritical carbon dioxide through a specially designed co-axial mixing nozzle into a particle formation vessel at constant temperature and pressure.The supercritical fluid dissolves the solvent leading to the formation of particles, which are retained in the vessel.By changing the processing parameters and solvent system it is possible to direct particle characteristics.Using the Nektar Supercritical Fluid Technol. ^TM process it is possible to provide co-formulated samples with an enhanced dissolution profile for poorly water-soluble drugs.Co-formulated samples show complete and rapid drug dissolution

PMSE Preprints

Enhanced drug dissolution using polymer: Drug co-formulations prepared by supercritical fluid technology

Author: Daintree, Lyn S. ; Jiang, Zhong ; Wilkins, Simon A. ; York, Peter ; Kordikowski, Andreas ; Green, Jennifer A.

Using the Nektar Supercritical Fluid Technol. process it is possible to provide co-formulated samples with an enhanced dissolution profile for poorly water-soluble drugs.Co-formulated samples show complete and rapid drug dissolutionThis work examines poorly water-soluble drug mols. co-formulated using Nektar Supercritical Fluid Technol.Present conventional technol. does not allow for control of particle characteristics.The purpose of this study was thus to show that supercritical fluids offer an alternative approach to conventional drug-polymer co-formulation because particle characteristics such as size, residual solvent and morphol. can be directed.Using this technol., the drug particles can be dispersed as a solid solution or as a semicrystalline dispersion within the release-modifying polymer.Using the Nektar Supercritical Fluid Technol. process it is possible to provide co-formulated samples with an enhanced dissolution profile for poorly water-soluble drugs.Co-formulated samples show complete and rapid drug dissolution

100 Deals associated with Nektar Therapeutics UK Ltd.

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100 Translational Medicine associated with Nektar Therapeutics UK Ltd.

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Pipeline

Pipeline Snapshot as of 20 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

1

Phase 2 Clinical

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