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Overview

Tags

Congenital Disorders

Immune System Diseases

Neoplasms

Antibody drug conjugate (ADC)

Fusion protein

Cytokines

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

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Targets

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Disease Domain	Count

Immune System Diseases	1
Neoplasms	1

Top 5 Drug Type	Count

Antibody drug conjugate (ADC)	1
Fusion protein	1
Cytokines	1

Top 5 Target	Count

IFNγ(Interferon gamma)	1
IL-2Rβ(Interleukin-2 receptor beta chain)	1

In-line anal. of refractive index is required for efficient design and monitoring of supercritical fluid extraction and precipitation processes.A robust method was developed based on measurements of laser beam deviation using an interferometer and image processing system.Data on refractive index of CO₂-EtOH mixtures were obtained at pressures between 70 and 200 bar and temperatures between 308 and 363 K, for continuous flow of premixed solvents and for equilibrium gas phase below the mixture critical pressure.The refractive index of a mixture is a linear function of EtOH mole fraction and can adequately describe mixing and phase behavior in the vessel.For pure CO₂, refractive index was determined as a function of pressure and d. and its Lorentz-Lorenz functions determined

01 Mar 2002·Fluid Phase Equilibria

Phase equilibria for the CO2 + methanol + sulfathiazole system at high pressure

Author: Siddiqi, M. ; Palakodaty, S. ; Kordikowski, A.

The solubility of the drug sulfathiazole has been measured in pure and methanol modified CO₂.Temperatures were varied between 298 and 353 K and pressures between 10 and 20 MPa.Methanol mole fractions were varied between 0 and 0.15.Solubility of sulfathiazole was found to be between x_STZ = 1.2×10^-9 and 1.5×10^-5 depending on the composition of the fluid phase and operating temperature and pressure.Addnl., the solid-vapor equilibrium of the ternary system was determined with a high pressure view-cell at 353 K and 10 MPa.The exptl. data were used to construct ternary Gibbs-triangles at constant temperature and pressure.The Gibbs-triangles were used to determine the exptl. conditions for subsequent crystallizations of sulfathiazole from a saturated methanol solution using supercritical CO₂.Size, morphol. and yield of the particles were related to the exptl. conditions.The impact on processing conditions in supercritical fluid processes for particle design has been assessed.

01 Nov 2001·The Journal of Supercritical Fluids

Analysis of the supersaturation and precipitation process with supercritical CO2

Author: Bristow, S. ; Shekunov, B. Yu. ; Shekunov, T. ; York, P.

An antisolvent precipitation process was studied in which an ethanol solution of the model drug acetaminophen (paracetamol) was dispersed or mixed with supercritical CO₂ in a nozzle at high Reynolds numbersThe acetaminophen concentrations of the saturated and effluent solutions were measured by using an online dynamic solubility method.These solubilities allow supersaturation in the jet (pre-precipitation) and in the reservoir fluid (post-precipitation) to be determined independently.Process conditions of partial and complete miscibility were investigated and it was shown that above the mixture critical pressure the crystallization was determined by mixing and primary nucleation processes characteristic of liquid solutionsAnal. of supersaturation provided a simple and effective way of process optimization based upon particle size and product yield.

100 Deals associated with Nektar Therapeutics UK Ltd.

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100 Translational Medicine associated with Nektar Therapeutics UK Ltd.

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Pipeline

Pipeline Snapshot as of 24 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

1

Phase 1 Clinical

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