Maintaining function and participation through tailored 24-hour physical behaviours for people living multiple cardiorenal metabolic conditions and frailty

Start Date30 Jan 2025

Sponsor / Collaborator

University Hospitals of Leicester NHS Trust

ISRCTN33340595

/ RecruitingNot Applicable

Mixed methods study to explore the effectiveness and acceptability of face-to-face exercise-based rehabilitation for patients with Long Covid who were not hospitalised with their acute infection

Start Date30 Sep 2024

Sponsor / Collaborator

University Hospitals of Leicester NHS Trust

ISRCTN11981704

/ RecruitingNot Applicable

Surgery compared with sling immobilisation in the management of adults with a displaced fracture of the distal clavicle (DIDACT): a multi-centre, pragmatic, parallel group, non-inferiority, randomised controlled trial

Start Date01 Sep 2023

Sponsor / Collaborator

University Hospitals of Leicester NHS Trust

100 Clinical Results associated with University Hospitals of Leicester NHS Trust

0 Patents (Medical) associated with University Hospitals of Leicester NHS Trust

4,493

Literatures (Medical) associated with University Hospitals of Leicester NHS Trust

01 Dec 2025·Journal of Sport and Health Science

Interplay between physical activity volume and intensity with modeled life expectancy in women and men: A prospective cohort analysis

Article

Author: Dempsey, Paddy C ; Razieh, Cameron ; Henson, Joe ; Dempsey, Paddy C. ; Khunti, Kamlesh ; Laukkanen, Jari A. ; Maylor, Benjamin D. ; Maylor, Benjamin D ; Rowlands, Alex V ; Bhattacharjee, Atanu ; Davies, Melanie J ; Rowlands, Alex V. ; Chudasama, Yogini ; Edwardson, Charlotte ; Ekelund, Ulf ; Goldney, Jonathan ; Laukkanen, Jari A ; Yates, Thomas ; Davies, Melanie J. ; Zaccardi, Francesco

BACKGROUNDThere is a lack of research examining the interplay between objectively measured physical activity volume and intensity with life expectancy. The purpose of the study was to investigate the interplay between objectively measured PA volume and intensity profiles with modeled life expectancy in women and men within the UK Biobank cohort study and interpret findings in relation to brisk walking.METHODSIndividuals from UK Biobank with wrist-worn accelerometer data were included. The average acceleration and intensity gradient were extracted to describe the physical activity volume and intensity profile. Mortality data were obtained from national registries. Adjusted life expectancies were estimated using parametric flexible survival models.RESULTS40,953 (57.1%) women (median age = 61.9 years) and 30,820 (42.9%) men (63.1 years) were included. Over a median follow-up of 6.9 years, there were 1719 (2.4%) deaths (733 in women; 986 in men). At 60 years, life expectancy was progressively longer for higher physical activity volume and intensity profiles, reaching 95.6 years in women and 94.5 years in men at the 90th centile for both volume and intensity, corresponding to 3.4 additional years (95% confidence interval (95%CI): 2.4-4.4) in women and 4.6 additional years (95%CI: 3.6-5.6) in men compared to those at the 10th centiles. An additional 10-min or 30-min daily brisk walk was associated with 0.9 (95%CI: 0.5-1.3) and 1.4 years (95%CI: 0.9-1.9) longer life expectancy, respectively, in inactive women; and 1.4 years (95%CI: 1.0-1.8) and 2.5 (95%CI: 1.9-3.1) in inactive men.CONCLUSIONHigher physical activity volumes were associated with longer life expectancy, with a higher physical activity intensity profile further adding to a longer life. Adding as little as a 10-min brisk walk to daily activity patterns may result in a meaningful benefit to life expectancy.

01 Apr 2025·Journal of Orthopaedics

Lateral column midfoot injury: Do they all need fixation?

Article

Author: Greasley, Lauren ; Mason, Lyndon ; Airey, Grace ; Jeyaseelan, Lucky ; Boksh, Khalis ; Aamir, Junaid ; Chapman, James ; Tanaka, Hiro ; Elbannan, Mamdouh ; Kyaw, Htin ; Ward, Thomas R W ; Ward, Thomas R.W. ; Mangwani, Jitendra ; Myatt, Darren ; Drummond, Isabella

Introduction/purposeResearch on midfoot injuries have primarily concentrated on the central column and the Lisfranc ligament without amassing evidence on lateral column injuries. Classically lateral column injuries were treated with Kirschner wire fixation. Our aim was to analyse midfoot lateral column injuries and their methods of treatment.MethodsMulticentre observational study. Data was retrospectively collected from three centres on surgically treated midfoot fracture dislocations between 2011 and 2021. Radiographs were analysed using departmental PACS. All statistics was performed using SPSS 26.ResultsA total of 409 surgically treated midfoot injuries were identified for further investigation. Following analysis, a total of 235 cases were diagnosed as having a lateral column injury, and 222 had data available for further analysis. All but 1 case (234, 99.6 %) of lateral column injury was associated with central column injury and 166 cases (70.6 %) were associated with medial column injuries.There were 44 cases where the lateral column underwent Kirschner wire fixation, 23 lateral column plate fixations and 3 lateral column screw fixations. Most patients (147, 63 %) had no fixation for their lateral column injury with only 2.84 % losing alignment at subsequent follow up. The patients undergoing K wire fixation had a greater loss of alignment rate (5.88 %). The use of a bridge plate to fix the central column appears protective and purely ligamentous injury was a higher risk than an injury that included the bone.ConclusionLateral column injury occur in over half of midfoot fractures in this study. It rarely occurs alone and is most commonly related to three column injuries. Nevertheless, following stabilisation of the central column, additional fixation of injuries to the lateral unlikely to be required in the majority of cases. In cases where lateral column stabilisation is required, plates and screws may be preferable to K wires.

01 Mar 2025·Journal of Electrocardiology

Comparison of P-wave parameter changes after radiofrequency ablation and cryoballoon ablation for paroxysmal atrial fibrillation: An observational cohort study

Article

Author: Somani, Riyaz ; Abdelrazik, Ahmed ; Vali, Zakkariya ; Ng, G André ; Antoun, Ibrahim ; Li, Xin

BACKGROUNDPulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (PAF) can be performed using one-shot cryoballoon ablation (cryo) or point-by-point radiofrequency ablation (RF). This study compares the changes in P-wave parameters between both ablation methods.METHODSThis single-centre retrospective study included contact force RF and second-generation cryo for PAF between 2018 and 2019. Procedure success was defined by freedom of ECG-documented AF at 12 months. Digital 12‑leads ECGs with 1-50 hertz bandpass filters were monitored directly during the procedure. Corrected P-wave duration (PWDc), P-wave voltage (PWV), P-wave dispersion (PWDisp), and P-wave terminal force in V1 (PTFV1) were measured and compared between RF and cryo. Additional ablations outside pulmonary veins were excluded.RESULTSThe final analysis included 226 patients, and the freedom of AF rate was similar at the 12-month follow-up between RF and cryo (76 % vs 74 %, P = 0.12). PWDc and PWV increased and decreased, respectively in both arms. PTFV1 decreased in RF (-3.3 mm.s to -4.6 mm.s, P < 0.001) and cryo (-3.4 mm.s to -5.3 mm.s,P = 0.002). There were similar changes after RF and cryo in PWDc (F_{11, 1032} = 0.80, P = 0.85), PWV (F_{11, 1032} = 0.19,P = 0.06), and PWDisp (F_{11, 1032} = 0.16,P = 0.34) and PTFV1 (P = 0.39). Increased PWDc was correlated with failure of RF (hazard ratio [2.3], 95 % confidence interval [CI]: 1.4-5.9, p = 0.01) and cryo (HR: 2.1, 95 % CI (1.3-4.6), p = 0.02). Results were similar when patients on antiarrhythmic drugs were excluded.CONCLUSIONRF and cryo caused similar freedom of AF rate at 12 months in PAF and similar P-wave parameter changes.

100 Deals associated with University Hospitals of Leicester NHS Trust

100 Translational Medicine associated with University Hospitals of Leicester NHS Trust

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