Medinol Ltd.

TEL AVIV, Israel, Oct. 7, 2024 /PRNewswire/ -- Medinol Ltd. is pleased to announce the successful First-in-Human (FIH) implantation of the ChampioNIR Drug-Eluting Peripheral Stent by Drs Gerard S.Goh and Thodur Vasudevan of the Alfred Hospital in Melbourne Australia, introducing a revolutionary advancement in the mechanics, durability and drug delivery of peripheral drug eluting stents. The ChampioNIR Drug-Eluting Peripheral Stent System poses a transformational technology designed to improve patient outcomes and procedural success. In a first of its kind hybrid mechanical design, radial support is provided by the metallic component of the stent, whereas longitudinal structure is provided by a bioresorbable polymeric mesh providing unsurpassed flexibility and long-term durability in even the most challenging anatomies. Furthermore, a unique drug-elution paradigm releases drug from the entire cylindrical area of the stent, drastically reducing diffusion distances and allowing, for the first time, therapeutic dosing of a large peripheral vessel with a 'limus' drug for an extended period of time. "We were impressed with ChampioNIR's deliverability and its straightforward deployment", said Prof. Gerard S Goh, Head of Interventional Radiology at The Alfred Hospital. "The Frictionless Deployment Mechanism made the precise positioning of the stent very straightforward". Dr. Yoram Richter, CEO of Medinol, added: "Medinol is excited to bring to clinical practice the culmination of years of research and development into novel stent designs, tailor-made for unmet clinical challenges in vascular interventions". The CHAMPIONSHIP First In Human study will enroll a total of 30 patients across 7 sites in Australia and the United States. Prof. Sahil Parikh, PI of the CHAMPIONSHIP study commented "The ChampioNIR stent represents a breakthrough in treatment for SFA lesions. I am excited to see this device come to life after years of development." About Medinol Founded in 1992, Medinol is a privately held company with offices in the U.S. and Israel, employing over 300 people. Extending more than 30 years of experience in the stent market, Medinol is aggressively changing paradigms in how disease states are diagnosed and treated. By designing cutting edge scaffolds for stenting multiple areas of the human body, dramatically reducing complications in Structural Heart procedures and providing real time insights into physiological metrics through Implantable Microsensors, Medinol looks years into the future to create pioneering medical devices. For more information, see . Contact: Jeff Roach [email protected] Logo - WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

BOSTON--( BUSINESS WIRE )--Kojin Therapeutics, Inc., a pioneer in cell-state and ferroptosis biology and cutting-edge drug discovery, today announced the appointment of Harvey J. Berger, M.D. as its new chairman, president, and chief executive officer. A biotech-industry veteran, Dr. Berger is an experienced physician-scientist and entrepreneur, who brings over 35 years of global research and development (R&D), corporate, and commercial leadership experience to Kojin. He founded ARIAD Pharmaceuticals and led the company from a start-up to a fully integrated global oncology company. In this and other leadership roles, Dr. Berger spearheaded the development and approval of six innovative, breakthrough medicines for patients with cancer, cardiovascular disease, and autoimmune disease, as well as a cancer-diagnostic blood test. Kojin co-founder Professor Stuart Schreiber stated, “We are thrilled to welcome Dr. Berger, a long-time colleague and collaborator, as Kojin’s new chief executive. Ferroptosis and apoptosis have a yin-yang relationship, and apoptosis biology has had a transformative impact on medicine. As a new area of drug discovery, ferroptosis biology offers a wide-open opportunity for medicine and an area where Kojin has a strong first-mover advantage. Kojin is pioneering a new class of therapeutics that result from a deep mechanistic understanding of the human cellular plasticity that connects these two fundamental cell states.” Speaking on behalf of the Board of Directors, Dr. Eric de La Fortelle , managing partner of Cathay Health, said, "We invested in Kojin because of its first-rate potential to provide novel therapies for patients with chronic diseases based on completely new mechanisms of action. Transforming this cutting-edge science into attractive new medicines requires highly experienced and dedicated ‘drug hunters,’ which is why we are delighted that Dr. Berger has stepped in to lead the company in its next phases of development." Dr. Berger added, "I am grateful for the opportunity to take on the leadership of Kojin at this critical time and to collaborate closely again with Stuart Schreiber, our other scientific advisors, and our outstanding team of innovative scientists. I believe the company's deep understanding of ferroptosis and cellular metabolism, coupled with its multi-modality drug-discovery platform, position it for success in bringing life-saving medicines to patients in need of differentiated, first-in-class therapies for chronic diseases. Our priority is to translate stunning basic research discoveries to clinical medicine and make the transition to clinical development as soon as possible." Dr. Berger started in the biopharmaceutical industry in 1986 at Centocor – one of the first-generation biotech companies dedicated to pursuing the therapeutic and diagnostic applications of monoclonal antibodies – where he oversaw the company's R&D programs as executive vice president and president of research and development. Subsequent to his lengthy stint at ARIAD, he became executive chairman of Medinol, a leading worldwide medical device company dedicated to the science of cardiovascular intervention. Dr. Berger began his career in academic medicine at Yale School of Medicine and Emory School of Medicine, rising to professor with tenure. He received his M.D. from Yale School of Medicine and his B.S. from Colgate University and completed post-graduate training at Yale-New Haven Hospital. In the past several years, Dr. Berger has devoted his efforts to supporting several not-for-profit organizations, including the Dana-Farber Cancer Institute in Boston, whose mission is to defy cancer, as a governing trustee, chair of the trustee science committee, and a member of the executive committee, and The Cameron Boyce Foundation in Los Angeles, whose mission is to cure epilepsy, as a member of the board of directors. Kojin Co-Founders The Kojin founding team brings together leadership in chemical biology, genetics, immunology, cancer therapeutics, and drug discovery and development, and includes: Stuart Schreiber, Ph.D., Morris Loeb Professor of Chemistry and Chemical Biology Emeritus, Harvard University; founding core institute member emeritus, The Broad Institute of MIT and Harvard; and recipient of the Wolf Prize in Chemistry; Benjamin Cravett, Ph.D., Norton B. Gilula Chair of Chemical Biology, The Scripps Research Institute, and recipient of the Wolf Prize in Chemistry; Stephanie Dougan, Ph.D., associate professor of immunology, Harvard Medical School and principal investigator, cancer immunology and virology, Dana-Farber Cancer Institute; and Vasanthi Viswanathan, Ph.D., head of discovery biology, Kojin (formerly Schreiber Lab at The Broad Institute). Kojin Investors Kojin's current investor syndicate includes Cathay Health, Polaris Partners, Newpath Partners, Leaps by Bayer, AbbVie Ventures, Dana Farber’s Binney Street Capital, Eventide Life Sciences Fund, and Alexandria Venture Investments. About Ferroptosis Ferroptosis is a newly discovered form of programmed cell death that is biochemically and genetically differentiated from apoptosis, necrosis, and autophagy and is characterized by intra-cellular localization of iron and reactive oxygen species. This leads to iron-dependent accumulation of oxidatively damaged phospholipids within the cell membrane – a process that has been likened to a "grease fire" in the cell membrane, and which can be prevented or reversed by therapeutic interventions. About Kojin Based in Boston, Massachusetts and named after the Japanese deity that tamed fire for the good of humanity, Kojin is harnessing groundbreaking discoveries in cell-state and ferroptosis biology to develop first-in-class treatments for use in patients with cancer, and cardiovascular, immunologic, and degenerative diseases. Kojin has developed a drug-discovery platform that integrates computational chemistry, structural biology, chemical biology, target-informed screening, and mechanism-driven pharmacology to discover therapeutics that specifically modulate ferroptosis. More information about Kojin can be found on its website ( www.kojintx.com ) and on LinkedIn and X (formerly known as Twitter) . © 2024 Kojin Therapeutics, Inc. 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EluNIR-PERL, the latest addition to Medinol’s EluNIR family of DES products, has four radiopaque markers, two at each end of the stent, and a radiopaque catheter tip made of hybrid polymer-metal, to facilitate superior visualisation during PCI procedures EluNIR-PERL drug-eluting coronary stent closeup. (Credit: PRNewswire/ CoSo Health) Israeli medical device maker Medinol has received the US Food and Drug Administration (FDA) approval for its EluNIR-PERL drug-eluting stent (DES) system to treat coronary artery disease. EluNIR-PERL is the latest coronary stent in its EluNIR family of DES products and builds on the company’s existing EluNIR DES system. The system comes with four radiopaque markers, two at each end of the stent, and a radiopaque catheter tip made of hybrid polymer-metal. Its unique features facilitate superior visualisation during PCI procedures including navigation through complex anatomies and placement of the stent, said the medical device maker. Medinol CEO Yoram Richter said: “We are pleased to bring technologies to the US that focus both on the benefit to patients as well as unique and meaningful advantages to surgeons, allowing for precise stent placement, shorter procedure times and reduced radiation exposure.” EluNIR-PERL is the company’s seventh-generation stent and features a unique stent design that leverages its unique CoCr framework. The CoCr framework comprises struts with varying widths and integrates radiopaque markers into the structure of the stent system. In addition, the stent also features a specialised radiopaque-enhanced metal spring tip intended for navigating through complex anatomies. The advanced design features would enable physicians with accurate positional information and precise stent placement during PCI procedures, said the medical device company. Medinol intends to commercialise the EluNIR-PERL in the US, exclusively through CoSo Health, a healthcare supply and logistics company that distributes and sells medical devices. Building on its sales rep-light model, advanced cloud-based logistics platform and customised delivery model, CoSo Health is said to reduce waste from the supply chain. CoSo Health CEO Jae Lee said: “We are proud to distribute one of the world’s best drug-eluting stents via our intuitive and easy-to-use SaaS+ platform, which reduces layers in the supply chain.”