Wuxi Jemincare Shanhe Pharmaceutical Co., Ltd.

To evaluate the tolerability, safety and pharmacokinetic characteristics of single ascending doses of azithromycin sulfate nebulized inhalation solution in healthy Chinese adult subjects

Primary objective: To compare the in vivo pharmacokinetics of irinotecan liposome injection (trade name: Onivyde®, specification: 43 mg/10 mL) produced by Les Laboratoires Servier Industrie as the reference preparation and irinotecan liposome injection (specification: 43 mg/10 mL) produced by Wuxi Jiyushanhe Pharmaceutical Co., Ltd. as the test preparation, to investigate the pharmacokinetic behavior of irinotecan liposome in patients with advanced pancreatic cancer and to evaluate the bioequivalence of the two preparations. Secondary objective: To evaluate the safety of the test preparation irinotecan liposome injection in patients with advanced pancreatic cancer.

(1) To explore the effect of Huang's Sound Spray (Children's Type) in improving pharyngeal symptoms and signs and shortening the course of the disease. (2) To observe the safety of Huang's Sound Spray (Children's Type) in clinical application.