Delving into the Latest Updates on Sphinx Pharmaceuticals Corp with Synapse

Overview

The authors demonstrated that the hardware and software adjustments made to the automated SPA system can double the estimated time to failure and reduced average time of repair by 40%.The addition of real-time scheduling for automated procedure should lessen the impact of an unrecoverable crash, by allowing some plates that are currently processing to complete processing with a revised schedule.Increasing diligence in QC and instrument maintenance has reduced the frequency of malfunctions.

01 Jan 1996·Lipid Second Messengers

Phosphatidic Acid

Author: Bocckino, Stephen B. ; Exton, John H.

A review with many references on enzymes that produce and degrade phosphatidic acid (PA) and mechanisms involved in their regulation, with emphasize on phospholipase D, diacylglycerol kinase, and phosphatidate phosphohydrolase.Proposed physiol. roles for PA and signal transductions mechanism for agonist that alter cellular PA levels are discussed.

01 Nov 1994·The Journal of Organic Chemistry

Two Practical Syntheses of Sterically Congested Benzophenones

Author: Nichols, Jeffrey B. ; Wilson, Joseph W. ; Hollinshead, Sean P.

Two efficient syntheses of the sterically congested tetraortho-substituted benzophenone portion of balanol (a potent PKC inhibitor) in a protected form are described.Ortho lithiation reactions are employed for the preparation of the required 1,2,3-trisubstituted aryl aldehydes and for their subsequent coupling reactions.The resulting carbinol intermediates were then manipulated to the corresponding benzophenonecarboxylic acids.This chem. is amenable to large scale synthesis, and multigram quantities of final products have been prepared

100 Deals associated with Sphinx Pharmaceuticals Corp

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100 Translational Medicine associated with Sphinx Pharmaceuticals Corp

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Pipeline

Pipeline Snapshot as of 26 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

NSC-639366 ( PKC )	Neoplasms More	Pending
SPC-104065 ( Protein kinases )	Neoplasms More	Pending
SPC-103751 ( Protein kinases )	Melanoma More	Pending
NSC-636851 ( Protein kinases )	Neoplasms More	Pending
NSC-646958 ( PKC )	Neoplasms More	Pending